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TRPA1 transient receptor potential cation channel subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 8989, updated on 12-Aug-2018

Summary

Official Symbol
TRPA1provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:497
See related
Ensembl:ENSG00000104321 MIM:604775; Vega:OTTHUMG00000164516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEPS; FEPS1; ANKTM1
Summary
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
Expression
Biased expression in urinary bladder (RPKM 5.8), colon (RPKM 2.2) and 5 other tissues See more
Orthologs

Genomic context

See TRPA1 in Genome Data Viewer
Location:
8q21.11
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (72021251..72094885, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (72933486..72987819, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MSC antisense RNA 1 Neighboring gene musculin Neighboring gene ribosomal protein S20 pseudogene 20 Neighboring gene uncharacterized LOC105375896 Neighboring gene transient receptor potential cation channel subfamily A member 1 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 271

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • TRP channels, organism-specific biosystem (from REACTOME)
    TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity TAS
Traceable Author Statement
more info
 
calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium-release channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
channel activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
temperature-gated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
detection of chemical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
PubMed 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
response to organic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to pain IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
thermoception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
stereocilium bundle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily A member 1
Names
ankyrin-like with transmembrane domains 1
transformation-sensitive protein p120

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033890.1 RefSeqGene

    Range
    5001..59334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007332.2NP_015628.2  transient receptor potential cation channel subfamily A member 1

    See identical proteins and their annotated locations for NP_015628.2

    Status: REVIEWED

    Source sequence(s)
    AC016057, AC022867
    Consensus CDS
    CCDS34908.1
    UniProtKB/Swiss-Prot
    O75762
    Related
    ENSP00000262209.4, OTTHUMP00000226879, ENST00000262209.4, OTTHUMT00000379079
    Conserved Domains (5) summary
    cd00204
    Location:95218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:744972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486577
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:66118
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:97128
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    72021251..72094885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517624.2XP_011515926.1  transient receptor potential cation channel subfamily A member 1 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:120243
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:769997
    Ion_trans; Ion transport protein
    pfam12796
    Location:511602
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:91143
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:122153
    ANK; ANK repeat [structural motif]
  2. XM_011517625.2XP_011515927.1  transient receptor potential cation channel subfamily A member 1 isoform X2

    See identical proteins and their annotated locations for XP_011515927.1

    UniProtKB/Swiss-Prot
    O75762
    Conserved Domains (5) summary
    cd00204
    Location:95218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:744972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486577
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:66118
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:97128
    ANK; ANK repeat [structural motif]
  3. XM_017013946.1XP_016869435.1  transient receptor potential cation channel subfamily A member 1 isoform X2

    UniProtKB/Swiss-Prot
    O75762
    Conserved Domains (5) summary
    cd00204
    Location:95218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:744972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486577
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:66118
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:97128
    ANK; ANK repeat [structural motif]
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