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TRPA1 transient receptor potential cation channel subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 8989, updated on 12-Sep-2021

Summary

Official Symbol
TRPA1provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:497
See related
Ensembl:ENSG00000104321 MIM:604775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEPS; FEPS1; ANKTM1
Summary
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
Expression
Biased expression in urinary bladder (RPKM 5.8), colon (RPKM 2.2) and 5 other tissues See more
Orthologs
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Genomic context

See TRPA1 in Genome Data Viewer
Location:
8q21.11
Exon count:
29
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (72021250..72094885, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (72933485..72987819, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MSC antisense RNA 1 Neighboring gene musculin Neighboring gene ribosomal protein S20 pseudogene 20 Neighboring gene uncharacterized LOC105375896 Neighboring gene transient receptor potential cation channel subfamily A member 1 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 271

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity TAS
Traceable Author Statement
more info
 
enables calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-release channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables channel activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables temperature-gated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to pain IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thermoception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in stereocilium bundle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily A member 1
Names
ankyrin-like with transmembrane domains 1
transformation-sensitive protein p120
wasabi receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033890.1 RefSeqGene

    Range
    5001..59335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007332.3NP_015628.2  transient receptor potential cation channel subfamily A member 1

    See identical proteins and their annotated locations for NP_015628.2

    Status: REVIEWED

    Source sequence(s)
    AC016057, AC022867
    Consensus CDS
    CCDS34908.1
    UniProtKB/Swiss-Prot
    O75762
    Related
    ENSP00000262209.4, ENST00000262209.5
    Conserved Domains (6) summary
    COG0666
    Location:416623
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:97128
    ANK; ANK repeat [structural motif]
    pfam00520
    Location:744972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486577
    Ank_2; Ankyrin repeats (3 copies)
    pfam16752
    Location:3388
    TBCC_N; Tubulin-specific chaperone C N-terminal domain
    cl39094
    Location:80374
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    72021250..72094885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517624.2XP_011515926.1  transient receptor potential cation channel subfamily A member 1 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:120243
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:769997
    Ion_trans; Ion transport protein
    pfam12796
    Location:511602
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:91143
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:122153
    ANK; ANK repeat [structural motif]
  2. XM_011517625.2XP_011515927.1  transient receptor potential cation channel subfamily A member 1 isoform X2

    See identical proteins and their annotated locations for XP_011515927.1

    UniProtKB/Swiss-Prot
    O75762
    Conserved Domains (6) summary
    COG0666
    Location:416623
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:97128
    ANK; ANK repeat [structural motif]
    pfam00520
    Location:744972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486577
    Ank_2; Ankyrin repeats (3 copies)
    pfam16752
    Location:3388
    TBCC_N; Tubulin-specific chaperone C N-terminal domain
    cl39094
    Location:80374
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_017013946.1XP_016869435.1  transient receptor potential cation channel subfamily A member 1 isoform X2

    UniProtKB/Swiss-Prot
    O75762
    Conserved Domains (6) summary
    COG0666
    Location:416623
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:97128
    ANK; ANK repeat [structural motif]
    pfam00520
    Location:744972
    Ion_trans; Ion transport protein
    pfam12796
    Location:486577
    Ank_2; Ankyrin repeats (3 copies)
    pfam16752
    Location:3388
    TBCC_N; Tubulin-specific chaperone C N-terminal domain
    cl39094
    Location:80374
    Ank_2; Ankyrin repeats (3 copies)
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