Format

Send to:

Choose Destination

Trpa1 transient receptor potential cation channel, subfamily A, member 1 [ Mus musculus (house mouse) ]

Gene ID: 277328, updated on 15-Oct-2019

Summary

Official Symbol
Trpa1provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily A, member 1provided by MGI
Primary source
MGI:MGI:3522699
See related
Ensembl:ENSMUSG00000032769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anktm1; TRPA1b
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See Trpa1 in Genome Data Viewer
Location:
1; 1 A3
Exon count:
27
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (14872644..14918862, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (14862729..14908943, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5, pseudogene 1 Neighboring gene predicted gene, 33500 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene predicted gene 5048

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
channel activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
ion channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
osmolarity-sensing cation channel activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
temperature-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
calcium ion transmembrane import into cytosol ISO
Inferred from Sequence Orthology
more info
 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to carbon dioxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to cold ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
detection of chemical stimulus involved in sensory perception of pain IDA
Inferred from Direct Assay
more info
PubMed 
detection of chemical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of anion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
regulation of blood circulation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
response to cold IDA
Inferred from Direct Assay
more info
PubMed 
response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to organic cyclic compound IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
response to pain IDA
Inferred from Direct Assay
more info
PubMed 
response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
thermoception IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
urinary bladder smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
stereocilium bundle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transient receptor potential cation channel subfamily A member 1
Names
ankyrin-like with transmembrane domains protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348288.1NP_001335217.1  transient receptor potential cation channel subfamily A member 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC121789, AK045771, KF460461
    UniProtKB/Swiss-Prot
    Q8BLA8
    UniProtKB/TrEMBL
    V5TCP9
    Related
    ENSMUSP00000157371.1, ENSMUST00000235071.1
    Conserved Domains (4) summary
    cd00204
    Location:93219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:98129
    ANK; ANK repeat [structural motif]
    pfam00520
    Location:768945
    Ion_trans; Ion transport protein
    pfam12796
    Location:41129
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_177781.5NP_808449.1  transient receptor potential cation channel subfamily A member 1 isoform 1

    See identical proteins and their annotated locations for NP_808449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121789, AK045771
    Consensus CDS
    CCDS35516.1
    UniProtKB/Swiss-Prot
    Q8BLA8
    Related
    ENSMUSP00000043594.4, ENSMUST00000041447.4
    Conserved Domains (4) summary
    cd00204
    Location:93219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:800975
    Ion_trans; Ion transport protein
    pfam12796
    Location:487578
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:98129
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    14872644..14918862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center