Format

Send to:

Choose Destination

ABCC10 ATP binding cassette subfamily C member 10 [ Homo sapiens (human) ]

Gene ID: 89845, updated on 25-Nov-2021

Summary

Official Symbol
ABCC10provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 10provided by HGNC
Primary source
HGNC:HGNC:52
See related
Ensembl:ENSG00000124574 MIM:612509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP7; SIMRP7; EST182763
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in ovary (RPKM 3.1), spleen (RPKM 3.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ABCC10 in Genome Data Viewer
Location:
6p21.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43427538..43451994)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43395279..43418165)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 318 Neighboring gene ribosomal protein S2 pseudogene 28 Neighboring gene uncharacterized LOC105375065 Neighboring gene microRNA 6780b Neighboring gene uncharacterized LOC107986597 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene RNA, U6 small nuclear 1113, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in leukotriene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukotriene transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family C member 10
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
multidrug resistance-associated protein 7
NP_001185863.1
NP_001337447.1
NP_258261.2
XP_011513276.2
XP_011513287.1
XP_011513288.1
XP_016866934.1
XP_016866935.1
XP_016866936.1
XP_016866937.1
XP_016866938.1
XP_016866939.1
XP_016866940.1
XP_016866942.1
XP_016866943.1
XP_016866944.1
XP_016866945.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198934.2NP_001185863.1  ATP-binding cassette sub-family C member 10 isoform MRP7

    See identical proteins and their annotated locations for NP_001185863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MRP7) encodes the longest isoform (MRP7).
    Source sequence(s)
    AK000002, AL359813, AY032599
    Consensus CDS
    CCDS56430.1
    UniProtKB/Swiss-Prot
    Q5T3U5
    UniProtKB/TrEMBL
    A0A024RD21
    Related
    ENSP00000361608.4, ENST00000372530.9
    Conserved Domains (4) summary
    cd03244
    Location:12441463
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:598801
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:2191469
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:289551
    ABC_membrane; ABC transporter transmembrane region
  2. NM_001350518.2NP_001337447.1  ATP-binding cassette sub-family C member 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AL359813
    Conserved Domains (1) summary
    cl26602
    Location:81025
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
  3. NM_033450.3NP_258261.2  ATP-binding cassette sub-family C member 10 isoform MRP7A

    See identical proteins and their annotated locations for NP_258261.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MRP7A), also known as SIMRP7, has multiple differences, compared to variant MRP7. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant MRP7. The encoded protein (isoform MRP7A) is shorter than isoform MRP7.
    Source sequence(s)
    AL359813
    Consensus CDS
    CCDS4896.1
    UniProtKB/Swiss-Prot
    Q5T3U5
    Related
    ENSP00000244533.3, ENST00000244533.7
    Conserved Domains (4) summary
    cd03244
    Location:12161435
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:570773
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:1761441
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:246508
    ABC_membrane; ABC transporter transmembrane region

RNA

  1. NR_146762.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359813

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43427538..43451994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011446.2XP_016866935.1  ATP-binding cassette sub-family C member 10 isoform X3

  2. XM_017011447.2XP_016866936.1  ATP-binding cassette sub-family C member 10 isoform X3

  3. XM_017011453.1XP_016866942.1  ATP-binding cassette sub-family C member 10 isoform X7

  4. XM_017011451.1XP_016866940.1  ATP-binding cassette sub-family C member 10 isoform X6

  5. XM_017011449.1XP_016866938.1  ATP-binding cassette sub-family C member 10 isoform X4

  6. XM_017011448.2XP_016866937.1  ATP-binding cassette sub-family C member 10 isoform X4

  7. XM_017011450.2XP_016866939.1  ATP-binding cassette sub-family C member 10 isoform X5

  8. XM_017011445.2XP_016866934.1  ATP-binding cassette sub-family C member 10 isoform X1

  9. XM_011514974.3XP_011513276.2  ATP-binding cassette sub-family C member 10 isoform X2

  10. XM_017011454.2XP_016866943.1  ATP-binding cassette sub-family C member 10 isoform X8

  11. XM_017011455.2XP_016866944.1  ATP-binding cassette sub-family C member 10 isoform X8

  12. XM_011514986.3XP_011513288.1  ATP-binding cassette sub-family C member 10 isoform X9

    See identical proteins and their annotated locations for XP_011513288.1

    Conserved Domains (4) summary
    cd03244
    Location:593812
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:2150
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG4987
    Location:278815
    CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    cl00549
    Location:308540
    ABC_membrane; ABC transporter transmembrane region
  13. XM_017011456.2XP_016866945.1  ATP-binding cassette sub-family C member 10 isoform X9

    Conserved Domains (4) summary
    cd03244
    Location:593812
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:2150
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG4987
    Location:278815
    CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    cl00549
    Location:308540
    ABC_membrane; ABC transporter transmembrane region
  14. XM_011514985.3XP_011513287.1  ATP-binding cassette sub-family C member 10 isoform X9

    See identical proteins and their annotated locations for XP_011513287.1

    Conserved Domains (4) summary
    cd03244
    Location:593812
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:2150
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG4987
    Location:278815
    CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    cl00549
    Location:308540
    ABC_membrane; ABC transporter transmembrane region

RNA

  1. XR_002956313.1 RNA Sequence

  2. XR_001743721.1 RNA Sequence

  3. XR_001743722.1 RNA Sequence

  4. XR_001743723.1 RNA Sequence

  5. XR_002956312.1 RNA Sequence

  6. XR_001743720.1 RNA Sequence

  7. XR_001743719.1 RNA Sequence

Support Center