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Cancer Chemother Pharmacol. 2016 Sep;78(3):595-603. doi: 10.1007/s00280-016-3114-7. Epub 2016 Jul 28.

Protein expression of ATP-binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients.

Author information

1
Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
2
Department of Pathology, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
3
Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic.
4
Deparment of Surgery, Faculty Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
5
Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 76, 323 00, Pilsen, Czech Republic. pavel.soucek@lfp.cuni.cz.

Abstract

PURPOSE:

This study investigated the prognostic importance of protein expression of ATP-binding cassette (ABC) transporters ABCC10 and ABCC11 in colorectal cancer.

METHODS:

Protein content of ABCC10 and ABCC11 was assessed in tumor tissue blocks of 140 colorectal cancer patients and associated with survival of patients with regard to 5-fluorouracil-based therapy.

RESULTS:

Low ABCC10 protein content in tumors increased hazard ratio of patient's death more than three times in comparison with high ABCC10-expressing tumors (P = 0.004). In contrast, the low ABCC11 content increased the hazard ratio of cancer recurrence in patients almost four times (P = 0.016). Analysis of patients treated with regimens based on 5-fluorouracil revealed that patients with low ABCC11 content in their tumors had shorter disease-free interval than those with higher content (P = 0.024).

CONCLUSIONS:

The present study shows for the first time that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients and provides strong impulse for further validation of their prognostic value in colorectal cancer.

KEYWORDS:

Colorectal cancer; Immunohistochemistry; Prognosis; Protein

PMID:
27468921
DOI:
10.1007/s00280-016-3114-7
[Indexed for MEDLINE]

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