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UMODL1 uromodulin like 1 [ Homo sapiens (human) ]

Gene ID: 89766, updated on 24-Nov-2020

Summary

Official Symbol
UMODL1provided by HGNC
Official Full Name
uromodulin like 1provided by HGNC
Primary source
HGNC:HGNC:12560
See related
Ensembl:ENSG00000177398 MIM:613859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See UMODL1 in Genome Data Viewer
Location:
21q22.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (42062877..42142996)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43483068..43563105)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 21 Neighboring gene ZNF295 antisense RNA 1 Neighboring gene uncharacterized LOC107985502 Neighboring gene UMODL1 antisense RNA 1 Neighboring gene uncharacterized LOC105372814 Neighboring gene ATP binding cassette subfamily G member 1 Neighboring gene RNA, 5S ribosomal pseudogene 492 Neighboring gene trefoil factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of uromodulin-like 1 (UMODL1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
cellular response to gonadotropin-releasing hormone IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal reproductive process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
neutrophil migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uromodulin-like 1
Names
olfactorin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055246.1 RefSeqGene

    Range
    5001..85037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004416.3NP_001004416.3  uromodulin-like 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001620, AP001621, AP001622
    Consensus CDS
    CCDS42936.1
    Related
    ENSP00000386147.2, ENST00000408910.6
  2. NM_001199527.3NP_001186456.2  uromodulin-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001620, AP001621, AP001622
    Consensus CDS
    CCDS56215.1
    Related
    ENSP00000383279.1, ENST00000400427.5
  3. NM_001199528.4NP_001186457.3  uromodulin-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP001620, AP001621, AP001622
    Consensus CDS
    CCDS56214.1
    Related
    ENSP00000383276.1, ENST00000400424.6
    Conserved Domains (6) summary
    smart00179
    Location:825856
    EGF_CA; Calcium-binding EGF-like domain
    cd00063
    Location:631700
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00095
    Location:4585
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam00100
    Location:9211161
    Zona_pellucida; Zona pellucida-like domain
    pfam01390
    Location:326402
    SEA; SEA domain
    cl02507
    Location:724811
    SEA; SEA domain
  4. NM_173568.4NP_775839.4  uromodulin-like 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001620, AP001621, AP001622
    Consensus CDS
    CCDS42935.1
    Related
    ENSP00000386126.2, ENST00000408989.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    42062877..42142996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028507.1XP_016883996.1  uromodulin-like 1 isoform X2

    Conserved Domains (7) summary
    smart00179
    Location:921952
    EGF_CA; Calcium-binding EGF-like domain
    smart00241
    Location:10171257
    ZP; Zona pellucida (ZP) domain
    cd00063
    Location:727803
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00095
    Location:1553
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam00100
    Location:11501257
    Zona_pellucida; Zona pellucida-like domain
    pfam01390
    Location:294370
    SEA; SEA domain
    cl02507
    Location:820907
    SEA; SEA domain
  2. XM_011529797.1XP_011528099.1  uromodulin-like 1 isoform X3

    See identical proteins and their annotated locations for XP_011528099.1

    Conserved Domains (6) summary
    smart00179
    Location:847878
    EGF_CA; Calcium-binding EGF-like domain
    smart00241
    Location:9431183
    ZP; Zona pellucida (ZP) domain
    cd00063
    Location:653729
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00100
    Location:10761183
    Zona_pellucida; Zona pellucida-like domain
    pfam01390
    Location:220296
    SEA; SEA domain
    cl02507
    Location:746833
    SEA; SEA domain
  3. XM_017028508.1XP_016883997.1  uromodulin-like 1 isoform X4

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