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WASL WASP like actin nucleation promoting factor [ Homo sapiens (human) ]

Gene ID: 8976, updated on 8-Jul-2021

Summary

Official Symbol
WASLprovided by HGNC
Official Full Name
WASP like actin nucleation promoting factorprovided by HGNC
Primary source
HGNC:HGNC:12735
See related
Ensembl:ENSG00000106299 MIM:605056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NWASP; WASPB; N-WASP
Summary
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in colon (RPKM 25.7), thyroid (RPKM 23.4) and 25 other tissues See more
Orthologs
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Genomic context

See WASL in Genome Data Viewer
Location:
7q31.32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (123681943..123749003, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123321997..123389057, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 15 Neighboring gene ASB15 antisense RNA 1 Neighboring gene leiomodin 2 Neighboring gene WASL divergent transcript Neighboring gene hyaluronidase 4 Neighboring gene RNA, U6 small nuclear 11, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available
New gene functions in megakaryopoiesis and platelet formation.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef inhibits the concomitant activation of the actin organizer N-Wasp by interfering with the translocation of N-Wasp to the cell periphery and blocks morphological changes induced by the known N-Wasp regulators Rac1 and Cdc42 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC48327, DKFZp779G0847

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin polymerization or depolymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular protein-containing complex localization IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of clathrin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in spindle localization IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle budding from membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle transport along actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in actin cap IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neural Wiskott-Aldrich syndrome protein
Names
Wiskott-Aldrich syndrome like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003941.4NP_003932.3  neural Wiskott-Aldrich syndrome protein

    See identical proteins and their annotated locations for NP_003932.3

    Status: REVIEWED

    Source sequence(s)
    BC028602, BC052955, DB380642
    Consensus CDS
    CCDS34743.1
    UniProtKB/Swiss-Prot
    O00401
    Related
    ENSP00000223023.4, ENST00000223023.5
    Conserved Domains (4) summary
    cd01205
    Location:40138
    EVH1_WASP-like; WASP family proteins EVH1 domain
    pfam00786
    Location:202259
    PBD; P21-Rho-binding domain
    cd22074
    Location:402428
    WH2_N-WASP_r1; first tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
    cd22075
    Location:429453
    WH2_hN-WASP_r2_like; second tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    123681943..123749003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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