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ENDOU endonuclease, poly(U) specific [ Homo sapiens (human) ]

Gene ID: 8909, updated on 1-Mar-2024

Summary

Official Symbol
ENDOUprovided by HGNC
Official Full Name
endonuclease, poly(U) specificprovided by HGNC
Primary source
HGNC:HGNC:14369
See related
Ensembl:ENSG00000111405 MIM:606720; AllianceGenome:HGNC:14369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P11; PP11; PRSS26
Summary
This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Expression
Biased expression in esophagus (RPKM 34.0), skin (RPKM 9.4) and 1 other tissue See more
Orthologs
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Genomic context

See ENDOU in Genome Data Viewer
Location:
12q13.11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (47709734..47725490, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (47671053..47686808, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48103517..48119273, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene STBD1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48030175-48030714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6256 Neighboring gene RNA polymerase II associated protein 3 Neighboring gene H3K27ac hESC enhancers GRCh37_chr12:48099027-48099528 and GRCh37_chr12:48099529-48100028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6259 Neighboring gene RPAP3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4395 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:48131928-48133127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6261 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48146243-48146784 Neighboring gene Sharpr-MPRA regulatory region 8178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6263 Neighboring gene Rap guanine nucleotide exchange factor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48151874-48152542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48152543-48153211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48167242-48167748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48167749-48168253 Neighboring gene solute carrier family 48 member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4399 Neighboring gene uncharacterized LOC124902926 Neighboring gene histone deacetylase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC133268

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA endonuclease activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables growth factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding TAS
Traceable Author Statement
more info
PubMed 
enables polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of lipid catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in post-transcriptional gene silencing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
uridylate-specific endoribonuclease
Names
22 serine protease
26 serine protease
endonuclease, polyU-specific
placental protein 11
poly(U)-specific endoribonuclease
protein endoU

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172439.2NP_001165910.1  uridylate-specific endoribonuclease isoform 1 precursor

    See identical proteins and their annotated locations for NP_001165910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AI039727, AK075446, BC069698
    Consensus CDS
    CCDS53785.1
    UniProtKB/Swiss-Prot
    B2RBJ3, B3KQS7, B7Z6E1, P21128, Q2NKJ4
    Related
    ENSP00000397679.3, ENST00000422538.8
    Conserved Domains (3) summary
    smart00201
    Location:86128
    SO; Somatomedin B -like domains
    pfam01033
    Location:2260
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:139405
    XendoU; Endoribonuclease XendoU
  2. NM_001172440.2NP_001165911.1  uridylate-specific endoribonuclease isoform 3 precursor

    See identical proteins and their annotated locations for NP_001165911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004241, AI039727, AK300169, DC381238
    Consensus CDS
    CCDS53784.1
    UniProtKB/Swiss-Prot
    P21128
    Related
    ENSP00000445004.2, ENST00000545824.2
    Conserved Domains (2) summary
    smart00201
    Location:2365
    SO; Somatomedin B -like domains
    pfam09412
    Location:76342
    XendoU; Endoribonuclease XendoU
  3. NM_006025.4NP_006016.1  uridylate-specific endoribonuclease isoform 2 precursor

    See identical proteins and their annotated locations for NP_006016.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004241, AI039727, BC111782
    Consensus CDS
    CCDS8754.1
    UniProtKB/Swiss-Prot
    P21128
    Related
    ENSP00000229003.3, ENST00000229003.7
    Conserved Domains (2) summary
    smart00201
    Location:4587
    SO; Somatomedin B -like domains
    pfam09412
    Location:98364
    XendoU; Endoribonuclease XendoU

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    47709734..47725490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    47671053..47686808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)