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ENDOU endonuclease, poly(U) specific [ Homo sapiens (human) ]

Gene ID: 8909, updated on 5-Aug-2018

Summary

Official Symbol
ENDOUprovided by HGNC
Official Full Name
endonuclease, poly(U) specificprovided by HGNC
Primary source
HGNC:HGNC:14369
See related
Ensembl:ENSG00000111405 MIM:606720; Vega:OTTHUMG00000169670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P11; PP11; PRSS26
Summary
This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]
Expression
Biased expression in esophagus (RPKM 34.0), skin (RPKM 9.4) and 1 other tissue See more
Orthologs

Genomic context

See ENDOU in Genome Data Viewer
Location:
12q13.11
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (47709734..47725572, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48103517..48119355, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene starch binding domain 1 pseudogene Neighboring gene RNA polymerase II associated protein 3 Neighboring gene uncharacterized LOC105369748 Neighboring gene Rap guanine nucleotide exchange factor 3 Neighboring gene solute carrier family 48 member 1 Neighboring gene histone deacetylase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133268

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity NAS
Non-traceable Author Statement
more info
PubMed 
manganese ion binding TAS
Traceable Author Statement
more info
PubMed 
polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
poly(U)-specific endoribonuclease
Names
22 serine protease
26 serine protease
endonuclease, polyU-specific
placental protein 11
protein endoU
uridylate-specific endoribonuclease
NP_001165910.1
NP_001165911.1
NP_006016.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172439.1NP_001165910.1  poly(U)-specific endoribonuclease isoform 1 precursor

    See identical proteins and their annotated locations for NP_001165910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AI039727, AK075446, BC069698, DA841959
    Consensus CDS
    CCDS53785.1
    UniProtKB/Swiss-Prot
    P21128
    Related
    ENSP00000397679.3, OTTHUMP00000241831, ENST00000422538.7, OTTHUMT00000405352
    Conserved Domains (3) summary
    smart00201
    Location:86128
    SO; Somatomedin B -like domains
    pfam01033
    Location:2260
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:139405
    XendoU; Endoribonuclease XendoU
  2. NM_001172440.1NP_001165911.1  poly(U)-specific endoribonuclease isoform 3 precursor

    See identical proteins and their annotated locations for NP_001165911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame coding region segments, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC004241, AI039727, AK300169, DC381238
    Consensus CDS
    CCDS53784.1
    UniProtKB/Swiss-Prot
    P21128
    Related
    ENSP00000445004.2, OTTHUMP00000241832, ENST00000545824.2, OTTHUMT00000405353
    Conserved Domains (2) summary
    smart00201
    Location:2365
    SO; Somatomedin B -like domains
    pfam09412
    Location:76342
    XendoU; Endoribonuclease XendoU
  3. NM_006025.3NP_006016.1  poly(U)-specific endoribonuclease isoform 2 precursor

    See identical proteins and their annotated locations for NP_006016.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC004241, AI039727, BC111782, DA838842
    Consensus CDS
    CCDS8754.1
    UniProtKB/Swiss-Prot
    P21128
    Related
    ENSP00000229003.3, OTTHUMP00000241830, ENST00000229003.7, OTTHUMT00000405351
    Conserved Domains (2) summary
    smart00201
    Location:4587
    SO; Somatomedin B -like domains
    pfam09412
    Location:98364
    XendoU; Endoribonuclease XendoU

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    47709734..47725572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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