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Endou endonuclease, polyU-specific [ Mus musculus (house mouse) ]

Gene ID: 19011, updated on 23-Jun-2018

Summary

Official Symbol
Endouprovided by MGI
Official Full Name
endonuclease, polyU-specificprovided by MGI
Primary source
MGI:MGI:97746
See related
Ensembl:ENSMUSG00000022468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp11r; Tcl-30
Expression
Biased expression in thymus adult (RPKM 54.3) and lung adult (RPKM 2.5) See more
Orthologs

Genomic context

See Endou in Genome Data Viewer
Location:
15 F1; 15 53.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (97711015..97731405, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97541450..97561836, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41394 Neighboring gene RNA polymerase II associated protein 3 Neighboring gene predicted gene, 33531 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene uncharacterized LOC102636367

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune response IEA
Inferred from Electronic Annotation
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
poly(U)-specific endoribonuclease
Names
PP11-related protein
T-cell-specific protein 30
placental protein 11 related
placental protein 11-related protein
protein endoU
uridylate-specific endoribonuclease
NP_001162164.1
NP_032928.1
XP_006520680.1
XP_006520681.1
XP_017172000.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168693.1NP_001162164.1  poly(U)-specific endoribonuclease isoform 2 precursor

    See identical proteins and their annotated locations for NP_001162164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains different segments for its 5' UTR and coding region, compared to variant 1. The predicted protein (isoform 2) results from translation initiation at an upstream AUG and has a shorter N-terminus, when it is compared to isoform 1.
    Source sequence(s)
    AA119943, AC104225, AK132616
    Consensus CDS
    CCDS49712.1
    UniProtKB/Swiss-Prot
    Q3V188
    Related
    ENSMUSP00000097820.2, ENSMUST00000100249.9
    Conserved Domains (2) summary
    pfam01033
    Location:2260
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:140406
    XendoU; Endoribonuclease XendoU
  2. NM_008902.3NP_032928.1  poly(U)-specific endoribonuclease isoform 1

    See identical proteins and their annotated locations for NP_032928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC104225
    Consensus CDS
    CCDS27783.1
    UniProtKB/Swiss-Prot
    Q3V188
    Related
    ENSMUSP00000023105.3, ENSMUST00000023105.4
    Conserved Domains (2) summary
    pfam01033
    Location:130167
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:182448
    XendoU; Endoribonuclease XendoU

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    97711015..97731405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520618.2XP_006520681.1  poly(U)-specific endoribonuclease isoform X2

    Conserved Domains (2) summary
    pfam01033
    Location:644
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:124390
    XendoU; Endoribonuclease XendoU
  2. XM_006520617.3XP_006520680.1  poly(U)-specific endoribonuclease isoform X1

    Conserved Domains (2) summary
    pfam01033
    Location:69107
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:187453
    XendoU; Endoribonuclease XendoU
  3. XM_017316511.1XP_017172000.1  poly(U)-specific endoribonuclease isoform X3

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