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AP1G2 adaptor related protein complex 1 subunit gamma 2 [ Homo sapiens (human) ]

Gene ID: 8906, updated on 17-Jun-2019

Summary

Official Symbol
AP1G2provided by HGNC
Official Full Name
adaptor related protein complex 1 subunit gamma 2provided by HGNC
Primary source
HGNC:HGNC:556
See related
Ensembl:ENSG00000213983 MIM:603534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G2AD
Summary
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in skin (RPKM 20.0), lymph node (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See AP1G2 in Genome Data Viewer
Location:
14q11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (23559565..23567939, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24028777..24038754, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene neuroguidin Neighboring gene thiamine triphosphatase Neighboring gene zinc finger homeobox 2 Neighboring gene uncharacterized LOC102724814 Neighboring gene junctophilin 4 Neighboring gene Sharpr-MPRA regulatory region 10629

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of adaptor-related protein complex 1, gamma 2 subunit (AP1G2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env The highly conserved C-terminal dileucine motif (residues 851-856) in the cytosolic domain of HIV-1 gp41 interacts with clathrin-associated AP-1 adaptor complexes PubMed
env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed
Nef nef Adaptor-related protein complex 1 (AP-1) is necessary for cross-presentation by MHC-I HLA-A and HLA-B molecules containing a cytoplasmic tail tyrosine signal and that HIV-1 Nef inhibits the cross-presentation in antigen-presenting cells PubMed
nef Exogenous Nef and TNF-alpha synergistically activate NF-kappaB and AP-1 resulting in enhancing viral replication in both chronically infected promonocytic cells and acutely infected primary macrophages PubMed
nef HIV-1 Nef stabilizes AP-1 complexes on endosomal membranes after ADP-ribosylation factor-1 (ARF1) -dependent attachment PubMed
nef The dileucine motif (residues 164-165) in HIV-1 Nef is required for binding to AP-1 complexes and stabilizing their association with membranes PubMed
nef A leucine-based motif near the C-terminus of HIV-1 Nef interacts with AP-1 complexes; residues 164 and 165 in Nef are required for the interaction with AP-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
    Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
    Lysosome Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
    trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport NAS
Non-traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
AP-1 adaptor complex TAS
Traceable Author Statement
more info
PubMed 
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AP-1 complex subunit gamma-like 2
Names
adaptor related protein complex 1 gamma 2 subunit
clathrin-associated/assembly/adaptor protein, large, gamma-2
gamma2-adaptin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011937.1 RefSeqGene

    Range
    5235..13508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282474.2NP_001269403.1  AP-1 complex subunit gamma-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001269403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI497879, BG701521, BX161425
    UniProtKB/TrEMBL
    Q86U03
    Conserved Domains (2) summary
    pfam02883
    Location:291399
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl26317
    Location:1194
    Adaptin_N; Adaptin N terminal region
  2. NM_001282475.2NP_001269404.1  AP-1 complex subunit gamma-like 2 isoform 3

    See identical proteins and their annotated locations for NP_001269404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AL135999, BC051833, BI918958, H41406
    UniProtKB/TrEMBL
    Q86V28
    Conserved Domains (2) summary
    smart00809
    Location:600708
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1503
    Adaptin_N; Adaptin N terminal region
  3. NM_001354673.2NP_001341602.1  AP-1 complex subunit gamma-like 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK304682, AL135999
    Conserved Domains (2) summary
    pfam01602
    Location:1446
    Adaptin_N; Adaptin N terminal region
    pfam02883
    Location:543651
    Alpha_adaptinC2; Adaptin C-terminal domain
  4. NM_001354674.2NP_001341603.1  AP-1 complex subunit gamma-like 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK304682, AL135999
    Conserved Domains (2) summary
    pfam02883
    Location:291399
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl26317
    Location:1194
    Adaptin_N; Adaptin N terminal region
  5. NM_001354675.2NP_001341604.1  AP-1 complex subunit gamma-like 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK304682, AL135999
    Conserved Domains (2) summary
    pfam02883
    Location:291399
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl26317
    Location:1194
    Adaptin_N; Adaptin N terminal region
  6. NM_001354677.2NP_001341606.1  AP-1 complex subunit gamma-like 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK304682, AL135999
    Conserved Domains (2) summary
    pfam02883
    Location:291399
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl26317
    Location:1194
    Adaptin_N; Adaptin N terminal region
  7. NM_001354681.2NP_001341610.1  AP-1 complex subunit gamma-like 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK304682, AL135999
    Conserved Domains (2) summary
    pfam02883
    Location:291399
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl26317
    Location:1194
    Adaptin_N; Adaptin N terminal region
  8. NM_003917.5NP_003908.1  AP-1 complex subunit gamma-like 2 isoform 1

    See identical proteins and their annotated locations for NP_003908.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB015318, BG701521, BQ073124
    Consensus CDS
    CCDS9602.1
    UniProtKB/Swiss-Prot
    O75843
    Related
    ENSP00000380309.3, ENST00000397120.7
    Conserved Domains (2) summary
    smart00809
    Location:672780
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24575
    Adaptin_N; Adaptin N terminal region

RNA

  1. NR_148937.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK304682, AL135999
  2. NR_148938.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK304682, AL135999

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    23559565..23567939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268173.3XP_005268230.1  AP-1 complex subunit gamma-like 2 isoform X5

    See identical proteins and their annotated locations for XP_005268230.1

    UniProtKB/Swiss-Prot
    O75843
    Conserved Domains (2) summary
    smart00809
    Location:672780
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24575
    Adaptin_N; Adaptin N terminal region
  2. XM_005268170.3XP_005268227.1  AP-1 complex subunit gamma-like 2 isoform X1

    See identical proteins and their annotated locations for XP_005268227.1

    Conserved Domains (2) summary
    smart00809
    Location:729837
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24632
    Adaptin_N; Adaptin N terminal region
  3. XM_005268174.3XP_005268231.1  AP-1 complex subunit gamma-like 2 isoform X6

    See identical proteins and their annotated locations for XP_005268231.1

    Conserved Domains (2) summary
    smart00809
    Location:600708
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1503
    Adaptin_N; Adaptin N terminal region
  4. XM_005268167.3XP_005268224.1  AP-1 complex subunit gamma-like 2 isoform X1

    See identical proteins and their annotated locations for XP_005268224.1

    Conserved Domains (2) summary
    smart00809
    Location:729837
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24632
    Adaptin_N; Adaptin N terminal region
  5. XM_006720301.3XP_006720364.1  AP-1 complex subunit gamma-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006720364.1

    Conserved Domains (2) summary
    smart00809
    Location:729837
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24632
    Adaptin_N; Adaptin N terminal region
  6. XM_005268180.4XP_005268237.1  AP-1 complex subunit gamma-like 2 isoform X8

    See identical proteins and their annotated locations for XP_005268237.1

    UniProtKB/TrEMBL
    Q86V28
    Conserved Domains (2) summary
    pfam02883
    Location:527635
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl26317
    Location:43430
    Adaptin_N; Adaptin N terminal region
  7. XM_005268175.3XP_005268232.1  AP-1 complex subunit gamma-like 2 isoform X6

    See identical proteins and their annotated locations for XP_005268232.1

    Conserved Domains (2) summary
    smart00809
    Location:600708
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1503
    Adaptin_N; Adaptin N terminal region
  8. XM_005268172.3XP_005268229.1  AP-1 complex subunit gamma-like 2 isoform X5

    See identical proteins and their annotated locations for XP_005268229.1

    UniProtKB/Swiss-Prot
    O75843
    Conserved Domains (2) summary
    smart00809
    Location:672780
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24575
    Adaptin_N; Adaptin N terminal region
  9. XM_005268169.3XP_005268226.1  AP-1 complex subunit gamma-like 2 isoform X1

    See identical proteins and their annotated locations for XP_005268226.1

    Conserved Domains (2) summary
    smart00809
    Location:729837
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24632
    Adaptin_N; Adaptin N terminal region
  10. XM_005268182.3XP_005268239.1  AP-1 complex subunit gamma-like 2 isoform X9

    Conserved Domains (2) summary
    smart00809
    Location:462570
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1365
    Adaptin_N; Adaptin N terminal region
  11. XM_017021741.1XP_016877230.1  AP-1 complex subunit gamma-like 2 isoform X4

  12. XM_024449738.1XP_024305506.1  AP-1 complex subunit gamma-like 2 isoform X11

    Conserved Domains (2) summary
    pfam02883
    Location:291399
    Alpha_adaptinC2; Adaptin C-terminal domain
    cl26317
    Location:1194
    Adaptin_N; Adaptin N terminal region
  13. XM_005268179.3XP_005268236.1  AP-1 complex subunit gamma-like 2 isoform X7

    See identical proteins and their annotated locations for XP_005268236.1

    Conserved Domains (2) summary
    pfam01602
    Location:1446
    Adaptin_N; Adaptin N terminal region
    pfam02883
    Location:543651
    Alpha_adaptinC2; Adaptin C-terminal domain
  14. XM_005268178.4XP_005268235.1  AP-1 complex subunit gamma-like 2 isoform X7

    See identical proteins and their annotated locations for XP_005268235.1

    Conserved Domains (2) summary
    pfam01602
    Location:1446
    Adaptin_N; Adaptin N terminal region
    pfam02883
    Location:543651
    Alpha_adaptinC2; Adaptin C-terminal domain
  15. XM_017021742.2XP_016877231.1  AP-1 complex subunit gamma-like 2 isoform X6

    Conserved Domains (2) summary
    smart00809
    Location:600708
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1503
    Adaptin_N; Adaptin N terminal region
  16. XM_005268168.5XP_005268225.1  AP-1 complex subunit gamma-like 2 isoform X1

    See identical proteins and their annotated locations for XP_005268225.1

    Conserved Domains (2) summary
    smart00809
    Location:729837
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24632
    Adaptin_N; Adaptin N terminal region
  17. XM_011537283.3XP_011535585.1  AP-1 complex subunit gamma-like 2 isoform X2

    Conserved Domains (2) summary
    smart00809
    Location:694802
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24600
    Adaptin_N; Adaptin N terminal region
  18. XM_017021740.1XP_016877229.1  AP-1 complex subunit gamma-like 2 isoform X3

  19. XM_017021745.1XP_016877234.1  AP-1 complex subunit gamma-like 2 isoform X10

RNA

  1. XR_001750584.2 RNA Sequence

  2. XR_001750588.2 RNA Sequence

  3. XR_001750583.2 RNA Sequence

    Related
    ENST00000535852.6
  4. XR_002957567.1 RNA Sequence

  5. XR_001750590.2 RNA Sequence

    Related
    ENST00000460049.6
  6. XR_002957569.1 RNA Sequence

  7. XR_002957568.1 RNA Sequence

  8. XR_001750589.1 RNA Sequence

    Related
    ENST00000465445.6
  9. XR_002957570.1 RNA Sequence

  10. XR_001750586.1 RNA Sequence

  11. XR_001750587.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_080545.1: Suppressed sequence

    Description
    NM_080545.1: This RefSeq was temporarily suppressed because insufficient data to support this transcript currently exist.
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