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SLC5A6 solute carrier family 5 member 6 [ Homo sapiens (human) ]

Gene ID: 8884, updated on 9-Jun-2020

Summary

Official Symbol
SLC5A6provided by HGNC
Official Full Name
solute carrier family 5 member 6provided by HGNC
Primary source
HGNC:HGNC:11041
See related
Ensembl:ENSG00000138074 MIM:604024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMVT
Expression
Broad expression in placenta (RPKM 17.5), testis (RPKM 16.1) and 24 other tissues See more
Orthologs

Genomic context

See SLC5A6 in Genome Data Viewer
Location:
2p23.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27199587..27212342, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27422455..27435175, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene proline rich 30 Neighboring gene transcription factor 23 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC5A6 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
biotin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
pantothenate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium-dependent multivitamin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biotin import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
biotin metabolic process TAS
Traceable Author Statement
more info
 
biotin transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pantothenate metabolic process TAS
Traceable Author Statement
more info
 
pantothenate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pantothenate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium-dependent multivitamin transporter
Names
Na(+)-dependent multivitamin transporter
Na+-dependent multivitamin transporter
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021095.4NP_066918.2  sodium-dependent multivitamin transporter

    See identical proteins and their annotated locations for NP_066918.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC013403
    Consensus CDS
    CCDS1740.1
    UniProtKB/Swiss-Prot
    Q9Y289
    UniProtKB/TrEMBL
    Q9HD19
    Related
    ENSP00000310208.3, ENST00000310574.8
    Conserved Domains (1) summary
    cd11504
    Location:24550
    SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain

RNA

  1. NR_028323.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has two differences in the presence and absence of alternate segments, compared to variant 1. This variant is represented as non-coding because the use of the 5' most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK027855, BG025980, BI832199, BQ651664, DA958474, DB452476, N30242
    Related
    ENST00000488743.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27199587..27212342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453207.1XP_024308975.1  sodium-dependent multivitamin transporter isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:24515
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_024453206.1XP_024308974.1  sodium-dependent multivitamin transporter isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:24517
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_011533146.3XP_011531448.1  sodium-dependent multivitamin transporter isoform X5

    Conserved Domains (1) summary
    cl00456
    Location:23327
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_006712129.1XP_006712192.1  sodium-dependent multivitamin transporter isoform X1

    See identical proteins and their annotated locations for XP_006712192.1

    UniProtKB/Swiss-Prot
    Q9Y289
    Conserved Domains (1) summary
    cd11504
    Location:24550
    SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain
  5. XM_006712130.1XP_006712193.1  sodium-dependent multivitamin transporter isoform X1

    See identical proteins and their annotated locations for XP_006712193.1

    UniProtKB/Swiss-Prot
    Q9Y289
    Conserved Domains (1) summary
    cd11504
    Location:24550
    SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain
  6. XM_006712128.2XP_006712191.1  sodium-dependent multivitamin transporter isoform X1

    See identical proteins and their annotated locations for XP_006712191.1

    UniProtKB/Swiss-Prot
    Q9Y289
    Related
    ENSP00000384853.1, ENST00000408041.5
    Conserved Domains (1) summary
    cd11504
    Location:24550
    SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain
  7. XM_017005216.1XP_016860705.1  sodium-dependent multivitamin transporter isoform X4

RNA

  1. XR_002959356.1 RNA Sequence

  2. XR_002959357.1 RNA Sequence

  3. XR_002959358.1 RNA Sequence

  4. XR_001739022.1 RNA Sequence

  5. XR_001739025.2 RNA Sequence

  6. XR_001739024.2 RNA Sequence

  7. XR_001739023.1 RNA Sequence

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