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KSR1 kinase suppressor of ras 1 [ Homo sapiens (human) ]

Gene ID: 8844, updated on 9-Feb-2020

Summary

Official Symbol
KSR1provided by HGNC
Official Full Name
kinase suppressor of ras 1provided by HGNC
Primary source
HGNC:HGNC:6465
See related
Ensembl:ENSG00000141068 MIM:601132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KSR; RSU2
Expression
Ubiquitous expression in placenta (RPKM 8.2), endometrium (RPKM 5.8) and 23 other tissues See more
Orthologs

Genomic context

See KSR1 in Genome Data Viewer
Location:
17q11.2
Exon count:
31
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (27456441..27626438)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (25799036..25950718)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371705 Neighboring gene TBC1 domain family member 3 pseudogene 5 Neighboring gene Myb/SANT DNA binding domain containing 3 pseudogene Neighboring gene integral membrane protein 2B pseudogene 1 Neighboring gene galectin 9 Neighboring gene nitric oxide synthase 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Ras protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
activation of MAPKKK activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinase suppressor of Ras 1
NP_001354739.1
NP_055053.1
XP_006722217.1
XP_011523731.1
XP_011523732.1
XP_011523733.1
XP_016880756.1
XP_016880759.1
XP_016880760.1
XP_016880761.1
XP_016880762.1
XP_016880763.1
XP_016880764.1
XP_016880765.1
XP_016880766.1
XP_016880767.1
XP_016880768.1
XP_016880769.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367810.1NP_001354739.1  kinase suppressor of Ras 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015688, AC069366
    Related
    ENSP00000494552.1, ENST00000644974.1
  2. NM_014238.2NP_055053.1  kinase suppressor of Ras 1 isoform 1

    See identical proteins and their annotated locations for NP_055053.1

    Status: VALIDATED

    Source sequence(s)
    AC015688, AC069366, BC037586, BC042106, BI829205, BX396814, U43586
    Consensus CDS
    CCDS58532.1
    UniProtKB/Swiss-Prot
    Q8IVT5
    Related
    ENSP00000381958.3, ENST00000398988.7
    Conserved Domains (3) summary
    cd00029
    Location:211253
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:475753
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:476740
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    27456441..27626438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025279.1XP_016880768.1  kinase suppressor of Ras 1 isoform X11

  2. XM_017025280.2XP_016880769.1  kinase suppressor of Ras 1 isoform X12

  3. XM_011525430.2XP_011523732.1  kinase suppressor of Ras 1 isoform X4

    Conserved Domains (4) summary
    cd00029
    Location:348390
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:612890
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:613877
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  4. XM_011525431.2XP_011523733.1  kinase suppressor of Ras 1 isoform X5

    Related
    ENSP00000438795.2, ENST00000509603.6
    Conserved Domains (4) summary
    cd00029
    Location:348390
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:612890
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:613877
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  5. XM_011525429.2XP_011523731.1  kinase suppressor of Ras 1 isoform X1

    See identical proteins and their annotated locations for XP_011523731.1

    UniProtKB/Swiss-Prot
    Q8IVT5
    Conserved Domains (4) summary
    cd00029
    Location:348390
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:612890
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:613877
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  6. XM_017025267.1XP_016880756.1  kinase suppressor of Ras 1 isoform X2

  7. XM_006722154.3XP_006722217.1  kinase suppressor of Ras 1 isoform X6

    See identical proteins and their annotated locations for XP_006722217.1

    Conserved Domains (4) summary
    cd00029
    Location:348390
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:576854
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:577841
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  8. XM_017025271.1XP_016880760.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/Swiss-Prot
    Q8IVT5
    Related
    ENSP00000268763.7, ENST00000268763.10
  9. XM_017025272.1XP_016880761.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/Swiss-Prot
    Q8IVT5
  10. XM_017025276.1XP_016880765.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/Swiss-Prot
    Q8IVT5
  11. XM_017025273.1XP_016880762.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/Swiss-Prot
    Q8IVT5
  12. XM_017025274.2XP_016880763.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/Swiss-Prot
    Q8IVT5
  13. XM_017025275.2XP_016880764.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/Swiss-Prot
    Q8IVT5
  14. XM_017025270.2XP_016880759.1  kinase suppressor of Ras 1 isoform X7

    Related
    ENSP00000494039.1, ENST00000644418.1
  15. XM_017025278.1XP_016880767.1  kinase suppressor of Ras 1 isoform X10

  16. XM_017025277.1XP_016880766.1  kinase suppressor of Ras 1 isoform X9

RNA

  1. XR_002958082.1 RNA Sequence

  2. XR_934587.3 RNA Sequence

  3. XR_934588.3 RNA Sequence

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