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KSR1 kinase suppressor of ras 1 [ Homo sapiens (human) ]

Gene ID: 8844, updated on 9-Jun-2024

Summary

Official Symbol
KSR1provided by HGNC
Official Full Name
kinase suppressor of ras 1provided by HGNC
Primary source
HGNC:HGNC:6465
See related
Ensembl:ENSG00000141068 MIM:601132; AllianceGenome:HGNC:6465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KSR; RSU2
Summary
Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 8.2), endometrium (RPKM 5.8) and 23 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See KSR1 in Genome Data Viewer
Location:
17q11.2
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (27456448..27626435)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28397924..28567909)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (25783474..25953461)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371705 Neighboring gene TBC1 domain family member 3 pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:25783139-25783640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25787154-25787857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25788561-25789264 Neighboring gene Sharpr-MPRA regulatory region 12448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25798863-25799627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25799628-25800392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25802427-25802940 Neighboring gene Sharpr-MPRA regulatory region 12304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25806167-25806668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11905 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:25830813-25832012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25833398-25833995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25838597-25839125 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25840412-25841256 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25841257-25842099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25846538-25847174 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:25859917-25860102 Neighboring gene MSANTD3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25865210-25866051 Neighboring gene uncharacterized LOC124903960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25867223-25868022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25869832-25870332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25870333-25870833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25894115-25895067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25896821-25897581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25917327-25917828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25917829-25918328 Neighboring gene integral membrane protein 2B pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25957839-25958656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:25964969-25965523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:25970104-25970797 Neighboring gene galectin 9 Neighboring gene nitric oxide synthase 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Ras protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinase suppressor of Ras 1
NP_001354739.1
NP_001381512.1
NP_001381513.1
NP_001381514.1
NP_055053.1
XP_006722217.1
XP_011523731.1
XP_011523733.1
XP_016880768.1
XP_016880769.1
XP_047292941.1
XP_047292942.1
XP_047292943.1
XP_047292944.1
XP_047292945.1
XP_047292946.1
XP_047292947.1
XP_047292948.1
XP_047292949.1
XP_047292950.1
XP_047292951.1
XP_047292952.1
XP_054173639.1
XP_054173640.1
XP_054173641.1
XP_054173642.1
XP_054173643.1
XP_054173644.1
XP_054173645.1
XP_054173646.1
XP_054173647.1
XP_054173648.1
XP_054173649.1
XP_054173650.1
XP_054173651.1
XP_054173652.1
XP_054173653.1
XP_054173654.1
XP_054173655.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367810.1NP_001354739.1  kinase suppressor of Ras 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015688, AC069366
    UniProtKB/TrEMBL
    A0A2R8Y4X0
    Conserved Domains (3) summary
    cd14152
    Location:590868
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cd20872
    Location:346392
    C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins
  2. NM_001394583.1NP_001381512.1  kinase suppressor of Ras 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC015688, AC069366
    Consensus CDS
    CCDS92281.1
    UniProtKB/TrEMBL
    A0A2R8Y4X0, A0A2R8Y5H9
    Related
    ENSP00000494552.1, ENST00000644974.2
    Conserved Domains (2) summary
    smart00109
    Location:348390
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd14152
    Location:590868
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
  3. NM_001394584.1NP_001381513.1  kinase suppressor of Ras 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC015688, AC069366
    UniProtKB/TrEMBL
    A8MY87
    Conserved Domains (2) summary
    smart00109
    Location:1254
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd14152
    Location:254532
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
  4. NM_001394585.1NP_001381514.1  kinase suppressor of Ras 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC015688, AC069366
    UniProtKB/TrEMBL
    A8MY87
    Conserved Domains (2) summary
    smart00109
    Location:1254
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd14152
    Location:240518
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
  5. NM_014238.2NP_055053.1  kinase suppressor of Ras 1 isoform 1

    See identical proteins and their annotated locations for NP_055053.1

    Status: VALIDATED

    Source sequence(s)
    AC015688, AC069366, BC037586, BC042106, BI829205, BX396814, U43586
    Consensus CDS
    CCDS58532.1
    UniProtKB/TrEMBL
    A0A2R8Y4X0
    Related
    ENSP00000381958.3, ENST00000398988.7
    Conserved Domains (3) summary
    cd00029
    Location:211253
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:475753
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:476740
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    27456448..27626435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436989.1XP_047292945.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  2. XM_047436985.1XP_047292941.1  kinase suppressor of Ras 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  3. XM_011525429.3XP_011523731.1  kinase suppressor of Ras 1 isoform X2

    See identical proteins and their annotated locations for XP_011523731.1

    UniProtKB/Swiss-Prot
    F8WEA9, H7BYU0, Q13476, Q8IVT5
    UniProtKB/TrEMBL
    A0A2R8Y4X0
    Conserved Domains (3) summary
    cd14152
    Location:612890
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cd20872
    Location:346392
    C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins
  4. XM_047436986.1XP_047292942.1  kinase suppressor of Ras 1 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  5. XM_006722154.4XP_006722217.1  kinase suppressor of Ras 1 isoform X5

    See identical proteins and their annotated locations for XP_006722217.1

    UniProtKB/TrEMBL
    A0A2R8Y4X0
    Conserved Domains (4) summary
    cd00029
    Location:348390
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:576854
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:577841
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  6. XM_047436987.1XP_047292943.1  kinase suppressor of Ras 1 isoform X6

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  7. XM_047436988.1XP_047292944.1  kinase suppressor of Ras 1 isoform X7

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  8. XM_011525431.3XP_011523733.1  kinase suppressor of Ras 1 isoform X4

    UniProtKB/TrEMBL
    A0A2R8Y4X0
    Conserved Domains (4) summary
    cd00029
    Location:348390
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:612890
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:613877
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13543
    Location:41168
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
  9. XM_017025280.3XP_016880769.1  kinase suppressor of Ras 1 isoform X14

  10. XM_017025279.2XP_016880768.1  kinase suppressor of Ras 1 isoform X12

  11. XM_047436991.1XP_047292947.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  12. XM_047436990.1XP_047292946.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y4X0
    Related
    ENSP00000494039.1, ENST00000644418.1
  13. XM_047436993.1XP_047292949.1  kinase suppressor of Ras 1 isoform X9

    UniProtKB/TrEMBL
    A8MY87
  14. XM_047436995.1XP_047292951.1  kinase suppressor of Ras 1 isoform X11

    UniProtKB/TrEMBL
    A8MY87
  15. XM_047436992.1XP_047292948.1  kinase suppressor of Ras 1 isoform X9

    UniProtKB/TrEMBL
    A8MY87
  16. XM_047436994.1XP_047292950.1  kinase suppressor of Ras 1 isoform X10

    UniProtKB/TrEMBL
    A8MY87
  17. XM_047436996.1XP_047292952.1  kinase suppressor of Ras 1 isoform X13

    UniProtKB/TrEMBL
    A8MY87
    Related
    ENSP00000381952.2, ENST00000398982.6

RNA

  1. XR_934587.4 RNA Sequence

  2. XR_007065523.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    28397924..28567909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317671.1XP_054173646.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  2. XM_054317664.1XP_054173639.1  kinase suppressor of Ras 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  3. XM_054317665.1XP_054173640.1  kinase suppressor of Ras 1 isoform X2

    UniProtKB/Swiss-Prot
    F8WEA9, H7BYU0, Q13476, Q8IVT5
    UniProtKB/TrEMBL
    A0A2R8Y4X0
  4. XM_054317666.1XP_054173641.1  kinase suppressor of Ras 1 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  5. XM_054317668.1XP_054173643.1  kinase suppressor of Ras 1 isoform X5

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  6. XM_054317669.1XP_054173644.1  kinase suppressor of Ras 1 isoform X6

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  7. XM_054317670.1XP_054173645.1  kinase suppressor of Ras 1 isoform X7

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  8. XM_054317667.1XP_054173642.1  kinase suppressor of Ras 1 isoform X4

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  9. XM_054317680.1XP_054173655.1  kinase suppressor of Ras 1 isoform X14

  10. XM_054317678.1XP_054173653.1  kinase suppressor of Ras 1 isoform X12

  11. XM_054317673.1XP_054173648.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  12. XM_054317672.1XP_054173647.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y4X0
  13. XM_054317675.1XP_054173650.1  kinase suppressor of Ras 1 isoform X9

    UniProtKB/TrEMBL
    A8MY87
  14. XM_054317677.1XP_054173652.1  kinase suppressor of Ras 1 isoform X11

    UniProtKB/TrEMBL
    A8MY87
  15. XM_054317674.1XP_054173649.1  kinase suppressor of Ras 1 isoform X9

    UniProtKB/TrEMBL
    A8MY87
  16. XM_054317676.1XP_054173651.1  kinase suppressor of Ras 1 isoform X10

    UniProtKB/TrEMBL
    A8MY87
  17. XM_054317679.1XP_054173654.1  kinase suppressor of Ras 1 isoform X13

    UniProtKB/TrEMBL
    A8MY87

RNA

  1. XR_008484960.1 RNA Sequence

  2. XR_008484961.1 RNA Sequence