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lecB fucose-binding lectin PA-IIL [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882528, updated on 24-Aug-2024

Summary

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Gene symbol
lecB
Gene description
fucose-binding lectin PA-IIL
Locus tag
PA3361
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (3773029..3773376)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene secretion protein Neighboring gene transporter protein AmiS Neighboring gene aliphatic amidase regulator Neighboring gene aliphatic amidase expression-regulating protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding. Gajdos L, et al. Nat Commun, 2022 Jan 11. PMID 35017516, Free PMC Article
  2. LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa. Gillon E, et al. Methods Mol Biol, 2020. PMID 32306354
  3. The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing. Thuenauer R, et al. mBio, 2020 Mar 10. PMID 32156827, Free PMC Article
  4. Glycosylation is required for outer membrane localization of the lectin LecB in Pseudomonas aeruginosa. Bartels KM, et al. J Bacteriol, 2011 Mar. PMID 21217000, Free PMC Article
  5. The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix. Passos da Silva D, et al. Nat Commun, 2019 May 16. PMID 31097723, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding.
    Title: Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding.
  2. LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa.
    Title: LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa.
  3. The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing.
    Title: The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing.
  4. Study demonstrates that Pseudomonas aeruginosa LecB binds to Psl, a key matrix exopolysaccharide (EPS), and this leads to increased retention of both cells and EPS in a growing biofilm. This interaction is predicted to occur between the LecB and the branched side chains present on Psl and coordinates Psl localization in the biofilm.
    Title: The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix.
  5. LecB binds to the outer membrane protein OprF
    Title: Specific association of lectin LecB with the surface of Pseudomonas aeruginosa: role of outer membrane protein OprF.
  6. It was reported that LecB is present in the periplasm of P. aeruginosa in two variants of different sizes and that glycosylation is required for the transport of LecB.
    Title: Glycosylation is required for outer membrane localization of the lectin LecB in Pseudomonas aeruginosa.
  7. The results demonstrate that there is a relationship between the LecA and LecB lectins and the pathogenicity of P. aeruginosa.
    Title: Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands.
  8. Altering specificity loop amino acids causes changes in the saccharide-binding preferences of lectins derived from PA-IIL, via creation or blocking possible binding interactions.
    Title: Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within single-species biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fucose-binding lectin PA-IIL
NP_252051.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    3773029..3773376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252051.1 fucose-binding lectin PA-IIL [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252051.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0N9LSG8
    Conserved Domains (1) summary
    pfam07472
    Location:7 → 114
    PA-IIL; Fucose-binding lectin II (PA-IIL)
Nucleotide Protein
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