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DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory [ Homo sapiens (human) ]

Gene ID: 8818, updated on 18-Aug-2020

Summary

Official Symbol
DPM2provided by HGNC
Official Full Name
dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by HGNC
Primary source
HGNC:HGNC:3006
See related
Ensembl:ENSG00000136908 MIM:603564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDG1U
Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 13.1), thyroid (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See DPM2 in Genome Data Viewer
Location:
9q34.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127935099..127937854, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130697374..130700763, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase like 1 Neighboring gene family with sequence similarity 102 member A Neighboring gene Sharpr-MPRA regulatory region 6856 Neighboring gene conserved acetylation island sequence 15 enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ80013, MGC21559, MGC111193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
dolichol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
preassembly of GPI anchor in ER membrane TAS
Traceable Author Statement
more info
 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
protein O-linked mannosylation TAS
Traceable Author Statement
more info
PubMed 
regulation of protein stability IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
dolichol phosphate-mannose biosynthesis regulatory protein
Names
DPM synthase complex subunit
DPM synthase subunit 2
dolichol-phosphate mannose synthase subunit 2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
NP_001365365.1
NP_001365366.1
NP_003854.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032927.1 RefSeqGene

    Range
    5001..8390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001378436.1NP_001365365.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL157935
  2. NM_001378437.1NP_001365366.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL157935
  3. NM_003863.4NP_003854.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform 1

    See identical proteins and their annotated locations for NP_003854.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS6886.1
    UniProtKB/Swiss-Prot
    O94777
    Related
    ENSP00000322181.8, ENST00000314392.12
    Conserved Domains (1) summary
    pfam07297
    Location:578
    DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

RNA

  1. NR_165631.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157935
  2. NR_165632.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157935

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127935099..127937854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152690.1: Suppressed sequence

    Description
    NM_152690.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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