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Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory [ Mus musculus (house mouse) ]

Gene ID: 13481, updated on 2-Nov-2024

Summary

Official Symbol
Dpm2provided by MGI
Official Full Name
dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by MGI
Primary source
MGI:MGI:1330238
See related
Ensembl:ENSMUSG00000026810 AllianceGenome:MGI:1330238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity and enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process; dolichol metabolic process; and regulation of protein stability. Predicted to be located in endoplasmic reticulum membrane and perinuclear region of cytoplasm. Predicted to be part of dolichol-phosphate-mannose synthase complex and glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 57.3), large intestine adult (RPKM 53.3) and 28 other tissues See more
Orthologs
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Genomic context

See Dpm2 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32460870..32463583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32570858..32573571)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene STARR-positive B cell enhancer ABC_E4433 Neighboring gene STARR-positive B cell enhancer ABC_E120 Neighboring gene STARR-seq mESC enhancer starr_04193 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32350767-32351080 Neighboring gene STARR-seq mESC enhancer starr_04196 Neighboring gene STARR-seq mESC enhancer starr_04197 Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene STARR-positive B cell enhancer ABC_E10095 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dolichyl-phosphate beta-D-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dolichol phosphate-mannose biosynthesis regulatory protein
Names
DPM synthase subunit 2
dolichol-phosphate (beta-D) mannosyltransferase 2
dolichol-phosphate mannose synthase subunit 2
NP_034203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010073.2NP_034203.1  dolichol phosphate-mannose biosynthesis regulatory protein

    See identical proteins and their annotated locations for NP_034203.1

    Status: VALIDATED

    Source sequence(s)
    BC008256
    Consensus CDS
    CCDS38104.1
    UniProtKB/Swiss-Prot
    Q9Z324
    UniProtKB/TrEMBL
    Q545R7
    Related
    ENSMUSP00000028151.7, ENSMUST00000028151.7
    Conserved Domains (1) summary
    pfam07297
    Location:578
    DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32460870..32463583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)