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GALR2 galanin receptor 2 [ Homo sapiens (human) ]

Gene ID: 8811, updated on 29-Mar-2020

Summary

Official Symbol
GALR2provided by HGNC
Official Full Name
galanin receptor 2provided by HGNC
Primary source
HGNC:HGNC:4133
See related
Ensembl:ENSG00000182687 MIM:603691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL2-R; GALNR2; GALR-2
Summary
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GALR2 in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76070824..76077537)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74070892..74073573)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TEN1-CDK3 readthrough (NMD candidate) Neighboring gene cyclin dependent kinase 3 Neighboring gene envoplakin Neighboring gene signal recognition particle 68 Neighboring gene zinc activated ion channel Neighboring gene exocyst complex component 7 Neighboring gene microRNA 6868

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125983, MGC125984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galanin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galanin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
feeding behavior TAS
Traceable Author Statement
more info
PubMed 
galanin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
learning or memory TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of large conductance calcium-activated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003857.4NP_003848.1  galanin receptor type 2

    See identical proteins and their annotated locations for NP_003848.1

    Status: REVIEWED

    Source sequence(s)
    AC018665, BC069130, BU631750
    Consensus CDS
    CCDS11739.1
    UniProtKB/Swiss-Prot
    O43603
    Related
    ENSP00000329684.3, ENST00000329003.4
    Conserved Domains (2) summary
    pfam00001
    Location:42292
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32177
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76070824..76077537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525427.3XP_011523729.1  galanin receptor type 2 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:25235
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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