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PEX11B peroxisomal biogenesis factor 11 beta [ Homo sapiens (human) ]

Gene ID: 8799, updated on 1-Jun-2020

Summary

Official Symbol
PEX11Bprovided by HGNC
Official Full Name
peroxisomal biogenesis factor 11 betaprovided by HGNC
Primary source
HGNC:HGNC:8853
See related
Ensembl:ENSG00000131779 MIM:603867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEX14B; PEX11-BETA
Summary
The protein encoded by this gene facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane. Several transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in brain (RPKM 12.5), thyroid (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See PEX11B in Genome Data Viewer
Location:
1q21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145911348..145918924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145516165..145523732)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985593 Neighboring gene integrin subunit alpha 10 Neighboring gene gonadotropin releasing hormone receptor 2 (pseudogene) Neighboring gene RNA binding motif protein 8A Neighboring gene LIX1L antisense RNA 1 Neighboring gene limb and CNS expressed 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RBM8A

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome fission IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome organization IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of peroxisome size IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of peroxisome size IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal membrane protein 11B
Names
peroxin-11B
peroxisomal biogenesis factor 11B
protein PEX11 homolog beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033000.3 RefSeqGene

    Range
    5208..12575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184795.1NP_001171724.1  peroxisomal membrane protein 11B isoform 2

    See identical proteins and their annotated locations for NP_001171724.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK301983, AW162134, BG435901, CB155824
    Consensus CDS
    CCDS72870.1
    UniProtKB/Swiss-Prot
    O96011
    Related
    ENSP00000437510.1, ENST00000537888.1
    Conserved Domains (1) summary
    pfam05648
    Location:4236
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
  2. NM_003846.3NP_003837.1  peroxisomal membrane protein 11B isoform 1

    See identical proteins and their annotated locations for NP_003837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK023991, AW162134, BG435901, DB054933
    Consensus CDS
    CCDS72871.1
    UniProtKB/Swiss-Prot
    O96011
    UniProtKB/TrEMBL
    A0A024R4E7
    Related
    ENSP00000358312.3, ENST00000369306.8
    Conserved Domains (1) summary
    pfam05648
    Location:1250
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RNA

  1. NR_073491.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW162134, BC011963, DB054933, HY108328
  2. NR_073492.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of the second exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC243547, AW162134, BC011963, BG423552, DB054933
  3. NR_073493.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' end compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK301983, AW162134, BC011963, DA157450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    145911348..145918924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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