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DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 [ Homo sapiens (human) ]

Gene ID: 8798, updated on 25-Nov-2021

Summary

Official Symbol
DYRK4provided by HGNC
Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 4provided by HGNC
Primary source
HGNC:HGNC:3095
See related
Ensembl:ENSG00000010219 MIM:609181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Expression
Broad expression in testis (RPKM 18.7), thyroid (RPKM 5.2) and 23 other tissues See more
Orthologs
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Genomic context

See DYRK4 in Genome Data Viewer
Location:
12p13.32
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (4562208..4613875)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (4671374..4724468)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 4 Neighboring gene RAD51 associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 10040 Neighboring gene coiled-coil domain containing 181 pseudogene Neighboring gene H3K27me3-DHS negatively-acting regulatory element H3 Neighboring gene A-kinase anchoring protein 3 Neighboring gene RAB5A, member RAS oncogene family pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NDUFA9

Homology

Clone Names

  • FLJ18618

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 4
Names
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4
NP_001269214.1
NP_001269215.1
NP_001358230.1
NP_001381708.1
NP_001381709.1
NP_003836.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282285.3NP_001269214.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC005832
    UniProtKB/TrEMBL
    D3JEN2
    Conserved Domains (1) summary
    cl21453
    Location:1114
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001282286.2NP_001269215.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_001269215.1

    Status: REVIEWED

    Source sequence(s)
    AC005832
    UniProtKB/TrEMBL
    B4E1A4
    Related
    ENST00000545571.5
    Conserved Domains (1) summary
    cl21453
    Location:1114
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001371301.2NP_001358230.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005832
    Related
    ENSP00000439697.2, ENST00000543431.5
    Conserved Domains (1) summary
    cd14225
    Location:175515
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  4. NM_001394779.1NP_001381708.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC005832
    Conserved Domains (1) summary
    cd14225
    Location:175515
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  5. NM_001394780.1NP_001381709.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC005832
    Conserved Domains (1) summary
    cd14225
    Location:169509
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
  6. NM_003845.3NP_003836.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_003836.1

    Status: REVIEWED

    Source sequence(s)
    AC005832
    Consensus CDS
    CCDS8530.1
    UniProtKB/Swiss-Prot
    Q9NR20
    Related
    ENSP00000441755.1, ENST00000540757.6
    Conserved Domains (1) summary
    cd14225
    Location:60400
    PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

RNA

  1. NR_104115.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in three exons and contains a 3' terminal exon that extends past a splice site that is used in variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005832, DB082653, GU139746
    Related
    ENST00000536157.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    4562208..4613875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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