U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 [ Homo sapiens (human) ]

Gene ID: 4704, updated on 22-Sep-2022

Summary

Official Symbol
NDUFA9provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit A9provided by HGNC
Primary source
HGNC:HGNC:7693
See related
Ensembl:ENSG00000139180 MIM:603834; AllianceGenome:HGNC:7693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CC6; CI39k; COQ11; CI-39k; MC1DN26; NDUFS2L; SDR22E1
Summary
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in heart (RPKM 54.9), colon (RPKM 38.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NDUFA9 in Genome Data Viewer
Location:
12p13.32
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (4649114..4694317)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (4655954..4701144)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (4758280..4803483)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:4737023-4738222 Neighboring gene A-kinase anchoring protein 3 Neighboring gene RAB5A, member RAS oncogene family pseudogene Neighboring gene GALNT8 antisense upstream 1 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene uncharacterized LOC124902863

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
enables NADH dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADH dehydrogenase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex I IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Names
CI-39kD
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NADH dehydrogenase (ubiquinone) Fe-S protein 2-like (NADH-coenzyme Q reductase)
NADH-ubiquinone oxidoreductase 39 kDa subunit
complex I 39kDa subunit
short chain dehydrogenase/reductase family 22E, member 1
NP_004993.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032124.1 RefSeqGene

    Range
    5001..43457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005002.5NP_004993.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor

    See identical proteins and their annotated locations for NP_004993.1

    Status: REVIEWED

    Source sequence(s)
    AC005832, BC009311, CB110957, L04490, R44283
    Consensus CDS
    CCDS8532.1
    UniProtKB/Swiss-Prot
    Q16795, Q2NKX0
    Related
    ENSP00000266544.5, ENST00000266544.10
    Conserved Domains (1) summary
    cd05271
    Location:54326
    NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    4649114..4694317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    4655954..4701144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)