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TNFRSF10A TNF receptor superfamily member 10a [ Homo sapiens (human) ]

Gene ID: 8797, updated on 4-Oct-2020

Summary

Official Symbol
TNFRSF10Aprovided by HGNC
Official Full Name
TNF receptor superfamily member 10aprovided by HGNC
Primary source
HGNC:HGNC:11904
See related
Ensembl:ENSG00000104689 MIM:603611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DR4; APO2; CD261; TRAILR1; TRAILR-1
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 4.9), appendix (RPKM 4.2) and 24 other tissues See more
Orthologs

Genomic context

See TNFRSF10A in Genome Data Viewer
Location:
8p21.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (23190452..23225102, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (23048970..23082680, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC254896 Neighboring gene TNF receptor superfamily member 10c Neighboring gene TNF receptor superfamily member 10d Neighboring gene ribosomal protein L23a pseudogene 55 Neighboring gene TNFRSF10A 5' regulatory region Neighboring gene uncharacterized LOC389641 Neighboring gene charged multivesicular body protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
GeneReviews: Not available
Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.
GeneReviews: Not available
Seven new loci associated with age-related macular degeneration.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Infectious wild type HIV-1 production is restricted by 293T cells over-expressing TNFRSF10A PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of CD4+ T cells with HIV-1 gp120 results in the upregulation of TRAIL death receptor expression and acquired sensitivity to TRAIL mediated cell death; this effect of gp120 requires the chemokine coreceptor CXCR4, but not CCR5 or the CD4 receptor PubMed
env Gp120-induced M-CSF downregulates the TRAIL receptor TRAIL-R1/DR4 and upregulates the anti-apoptotic genes Bfl-1 and Mcl-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
TRAIL binding NAS
Non-traceable Author Statement
more info
PubMed 
death receptor activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
TRAIL-activated apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
TRAIL-activated apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors NAS
Non-traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 10A
Names
TNF-related apoptosis-inducing ligand receptor 1
TRAIL receptor 1
TRAIL-R1
cytotoxic TRAIL receptor
death receptor 4
tumor necrosis factor receptor superfamily member 10a variant 2
tumor necrosis factor receptor superfamily, member 10a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032107.1 RefSeqGene

    Range
    5066..39716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003844.4NP_003835.3  tumor necrosis factor receptor superfamily member 10A

    See identical proteins and their annotated locations for NP_003835.3

    Status: REVIEWED

    Source sequence(s)
    AC100861, BC012866, CN423254
    Consensus CDS
    CCDS6039.1
    UniProtKB/Swiss-Prot
    O00220
    Related
    ENSP00000221132.3, ENST00000221132.8
    Conserved Domains (2) summary
    cd08315
    Location:367454
    Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors
    cd10580
    Location:129230
    TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    23190452..23225102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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