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TNFRSF10C TNF receptor superfamily member 10c [ Homo sapiens (human) ]

Gene ID: 8794, updated on 17-Jun-2024

Summary

Official Symbol
TNFRSF10Cprovided by HGNC
Official Full Name
TNF receptor superfamily member 10cprovided by HGNC
Primary source
HGNC:HGNC:11906
See related
Ensembl:ENSG00000173535 MIM:603613; AllianceGenome:HGNC:11906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 12.1), bone marrow (RPKM 9.2) and 17 other tissues See more
Orthologs
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Genomic context

See TNFRSF10C in Genome Data Viewer
Location:
8p21.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (23102921..23117445)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (23377859..23392387)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22960434..22974958)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984124 Neighboring gene Rho related BTB domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22845205-22845961 Neighboring gene RNA, 7SL, cytoplasmic 303, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861268-22861793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861794-22862318 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:22866186-22866771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22871840-22872604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27102 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22876025-22876192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22876488-22877052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22877053-22877615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22885758-22886258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22886259-22886759 Neighboring gene TNF receptor superfamily member 10b Neighboring gene Sharpr-MPRA regulatory region 6582 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:22921484-22922683 Neighboring gene TNFRSF10B antisense RNA 1 Neighboring gene TNFRSF10B 5' regulatory region Neighboring gene Sharpr-MPRA regulatory region 12406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22928365-22928864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22941919-22942800 Neighboring gene uncharacterized LOC254896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22960499-22961308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22976378-22976878 Neighboring gene MPRA-validated peak6942 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:23002103-23002830 Neighboring gene TNF receptor superfamily member 10d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27108 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:23025986-23026166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23031113-23031614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:23033956-23034512 Neighboring gene TNF receptor superfamily member 10a Neighboring gene ribosomal protein L23a pseudogene 55

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env-pseudotyped virus-infected monocyte-derived macrophage cells downregulate expression of TRAIL decoy receptors DcR1 and DcR2, and cellular FLICE-inhibitory protein (c-FLIP) PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 results in the upregulation of TRAIL death receptor expression and acquired sensitivity to TRAIL mediated cell death; this effect of gp120 requires the chemokine coreceptor CXCR4, but not CCR5 or the CD4 receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC149501, MGC149502

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables TRAIL binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in TRAIL-activated apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 10C
Names
TNF-related apoptosis-inducing ligand receptor 3
antagonist decoy receptor for TRAIL/Apo-2L
cytotoxic TRAIL receptor-3
decoy TRAIL receptor without death domain
decoy receptor 1
lymphocyte inhibitor of TRAIL
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032578.2 RefSeqGene

    Range
    5002..19526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003841.5NP_003832.3  tumor necrosis factor receptor superfamily member 10C precursor

    Status: REVIEWED

    Source sequence(s)
    AC107959
    Consensus CDS
    CCDS6037.1
    UniProtKB/Swiss-Prot
    O14755, O14798, Q08AS6, Q6FH98, Q6UXM5
    UniProtKB/TrEMBL
    B2R831
    Related
    ENSP00000349324.4, ENST00000356864.4
    Conserved Domains (2) summary
    PRK11907
    Location:163232
    PRK11907; bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
    cd10580
    Location:50150
    TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    23102921..23117445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    23377859..23392387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)