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FPGT fucose-1-phosphate guanylyltransferase [ Homo sapiens (human) ]

Gene ID: 8790, updated on 8-Jul-2021

Summary

Official Symbol
FPGTprovided by HGNC
Official Full Name
fucose-1-phosphate guanylyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:3825
See related
Ensembl:ENSG00000254685 MIM:603609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GFPP
Summary
L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in thyroid (RPKM 7.2), kidney (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

See FPGT in Genome Data Viewer
Location:
1p31.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (74198242..74208702)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (74663926..74674386)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U4atac small nuclear 8, pseudogene Neighboring gene leucine rich repeats and IQ motif containing 3 Neighboring gene FPGT-TNNI3K readthrough Neighboring gene TNNI3 interacting kinase Neighboring gene uncharacterized LOC105378805 Neighboring gene leucine rich repeat containing 53 Neighboring gene ERICH3 antisense RNA 1 Neighboring gene glutamate rich 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough FPGT-TNNI3K

Readthrough gene: FPGT-TNNI3K, Included gene: TNNI3K

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity TAS
Traceable Author Statement
more info
PubMed 
enables fucose-1-phosphate guanylyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in fucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fucose-1-phosphate guanylyltransferase
Names
GDP-L-fucose diphosphorylase
GDP-beta-L-fucose pyrophosphorylase
fucose-1-phosphate guanyltransferase
NP_001186257.3
NP_001186258.3
NP_003829.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199328.3NP_001186257.3  fucose-1-phosphate guanylyltransferase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC098692
    Related
    ENSP00000432819.1, ENST00000534056.5
    Conserved Domains (2) summary
    PRK13412
    Location:77136
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
    pfam07959
    Location:110279
    Fucokinase; L-fucokinase
  2. NM_001199329.3NP_001186258.3  fucose-1-phosphate guanylyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC098692
    Related
    ENSP00000359931.4, ENST00000370894.9
  3. NM_003838.5NP_003829.4  fucose-1-phosphate guanylyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC098692
    Consensus CDS
    CCDS663.2
    Related
    ENSP00000359935.4, ENST00000370898.9
    Conserved Domains (1) summary
    pfam07959
    Location:114533
    Fucokinase; L-fucokinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    74198242..74208702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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