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TNFRSF14 TNF receptor superfamily member 14 [ Homo sapiens (human) ]

Gene ID: 8764, updated on 2-Nov-2024

Summary

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Official Symbol
TNFRSF14provided by HGNC
Official Full Name
TNF receptor superfamily member 14provided by HGNC
Primary source
HGNC:HGNC:11912
See related
Ensembl:ENSG00000157873 MIM:602746; AllianceGenome:HGNC:11912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
Summary
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues See more
Orthologs
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Genomic context

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See TNFRSF14 in Genome Data Viewer
Location:
1p36.32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (2554234..2563829)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1997007..2005473)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2487810..2495268)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pantothenate kinase 4 (inactive) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2454755-2455542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2458062-2458782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2459504-2460224 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:2460225-2460944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2461459-2461962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2463669-2464169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2465753-2466256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2466257-2466760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2466761-2467264 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2474412-2475282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2476154-2477024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2479637-2480506 Neighboring gene TNFRSF14 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:2481723-2482922 Neighboring gene uncharacterized LOC100996583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2498904-2499776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2508969-2509605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2519024-2519656 Neighboring gene peroxiredoxin like 2B Neighboring gene membrane metalloendopeptidase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of HVEM, a Lymphocyte Regulator Gene, in Ovarian Cancer Cells Increases Sensitivity to Activated T Cells. Zhang T, et al. Oncol Res, 2016. PMID 27458100, Free PMC Article
  2. Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes. Meng Q, et al. J Immunol, 2019 Apr 1. PMID 30770415, Free PMC Article
  3. Characterization of herpes virus entry mediator as a factor linked to obesity. Bassols J, et al. Obesity (Silver Spring), 2010 Feb. PMID 19680232
  4. Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis. Cheung KJ, et al. Cancer Res, 2010 Nov 15. PMID 20884631
  5. High rate of TNFRSF14 gene alterations related to 1p36 region in de novo follicular lymphoma and impact on prognosis. Launay E, et al. Leukemia, 2012 Mar. PMID 21941365

See all (150) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The BTLA-HVEM axis restricts CAR T cell efficacy in cancer.
    Title: The BTLA-HVEM axis restricts CAR T cell efficacy in cancer.
  2. Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis.
    Title: Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis.
  3. MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-kappaB signaling pathway.
    Title: MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-κB signaling pathway.
  4. Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1[-] stem cell-like T cells over PD-1[+] T cells curbing tumor progression.
    Title: Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1(-) stem cell-like T cells over PD-1(+) T cells curbing tumor progression.
  5. Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2.
    Title: Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2.
  6. BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM.
    Title: BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM.
  7. The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases.
    Title: The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases.
  8. Clinical Significance of BTLA and HVEM Expression on Circulating CD4(+) T and CD8(+) T Cells in Chronic Hepatitis B Virus Infection.
    Title: Clinical Significance of BTLA and HVEM Expression on Circulating CD4(+) T and CD8(+) T Cells in Chronic Hepatitis B Virus Infection.
  9. HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
    Title: HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
  10. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype.
    Title: Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype.
Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
EBI GWAS Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) in human B cells PubMed
Vif vif HIV-1 Vif downregulates the expression of tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell costimulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of adaptive immune memory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of alpha-beta T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokine production involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 14
Names
CD40-like protein
herpes virus entry mediator A
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
tumor necrosis factor receptor-like gene2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047096.1 RefSeqGene

    Range
    5007..12465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297605.2 → NP_001284534.1  tumor necrosis factor receptor superfamily member 14 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BX343044, CD366981, DC383433
    UniProtKB/TrEMBL
    F6UPZ7
    Conserved Domains (1) summary
    cd10582
    Location:42 → 142
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)

  2. NM_003820.4 → NP_003811.2  tumor necrosis factor receptor superfamily member 14 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003811.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CD366981, DC383433, U70321
    Consensus CDS
    CCDS44046.1
    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
    UniProtKB/TrEMBL
    F6Q0M4
    Related
    ENSP00000347948.4, ENST00000355716.5
    Conserved Domains (3) summary
    cd00185
    Location:138 → 186
    TNFRSF; CRD2 [structural motif]
    cd10582
    Location:42 → 142
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    cl22855
    Location:98 → 196
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    2554234..2563829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433419.1 → XP_047289375.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  2. XM_047433418.1 → XP_047289374.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  3. XM_047433414.1 → XP_047289370.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  4. XM_047433412.1 → XP_047289368.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
    Related
    ENSP00000399292.2, ENST00000435221.6

  5. XM_047433416.1 → XP_047289372.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
    Related
    ENSP00000399533.1, ENST00000451778.5

  6. XM_047433413.1 → XP_047289369.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65
    Related
    ENSP00000415254.1, ENST00000434817.5

  7. XM_047433422.1 → XP_047289378.1  tumor necrosis factor receptor superfamily member 14 isoform X4

    UniProtKB/TrEMBL
    B9A034
    Related
    ENSP00000386859.1, ENST00000409119.5

  8. XM_006711019.3 → XP_006711082.1  tumor necrosis factor receptor superfamily member 14 isoform X3

    See identical proteins and their annotated locations for XP_006711082.1

    UniProtKB/TrEMBL
    F6UPZ7
    Conserved Domains (1) summary
    cd10582
    Location:42 → 142
    TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)

  9. XM_047433421.1 → XP_047289377.1  tumor necrosis factor receptor superfamily member 14 isoform X4

    UniProtKB/TrEMBL
    B9A034
    Related
    ENSP00000411854.1, ENST00000426449.5

  10. XM_047433423.1 → XP_047289379.1  tumor necrosis factor receptor superfamily member 14 isoform X5

  11. XM_011542383.3 → XP_011540685.1  tumor necrosis factor receptor superfamily member 14 isoform X2

    See identical proteins and their annotated locations for XP_011540685.1

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187515.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    106553..115019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328613.1 → XP_054184588.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  2. XM_054328611.1 → XP_054184586.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  3. XM_054328610.1 → XP_054184585.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  4. XM_054328618.1 → XP_054184593.1  tumor necrosis factor receptor superfamily member 14 isoform X4

    UniProtKB/TrEMBL
    B9A034

  5. XM_054328612.1 → XP_054184587.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  6. XM_054328614.1 → XP_054184589.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  7. XM_054328616.1 → XP_054184591.1  tumor necrosis factor receptor superfamily member 14 isoform X3

  8. XM_054328617.1 → XP_054184592.1  tumor necrosis factor receptor superfamily member 14 isoform X4

    UniProtKB/TrEMBL
    B9A034

  9. XM_054328619.1 → XP_054184594.1  tumor necrosis factor receptor superfamily member 14 isoform X5

  10. XM_054328609.1 → XP_054184584.1  tumor necrosis factor receptor superfamily member 14 isoform X7

  11. XM_054328608.1 → XP_054184583.1  tumor necrosis factor receptor superfamily member 14 isoform X6

  12. XM_054328615.1 → XP_054184590.1  tumor necrosis factor receptor superfamily member 14 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    1997007..2005473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339412.1 → XP_054195387.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  2. XM_054339410.1 → XP_054195385.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  3. XM_054339409.1 → XP_054195384.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  4. XM_054339417.1 → XP_054195392.1  tumor necrosis factor receptor superfamily member 14 isoform X4

    UniProtKB/TrEMBL
    B9A034

  5. XM_054339411.1 → XP_054195386.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  6. XM_054339413.1 → XP_054195388.1  tumor necrosis factor receptor superfamily member 14 isoform X1

    UniProtKB/Swiss-Prot
    B3KW30, B9DI89, Q6IB95, Q8N634, Q8WXR1, Q92956, Q96J31, Q9UM65

  7. XM_054339415.1 → XP_054195390.1  tumor necrosis factor receptor superfamily member 14 isoform X3

  8. XM_054339416.1 → XP_054195391.1  tumor necrosis factor receptor superfamily member 14 isoform X4

    UniProtKB/TrEMBL
    B9A034

  9. XM_054339418.1 → XP_054195393.1  tumor necrosis factor receptor superfamily member 14 isoform X5

  10. XM_054339408.1 → XP_054195383.1  tumor necrosis factor receptor superfamily member 14 isoform X9

  11. XM_054339407.1 → XP_054195382.1  tumor necrosis factor receptor superfamily member 14 isoform X8

  12. XM_054339414.1 → XP_054195389.1  tumor necrosis factor receptor superfamily member 14 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92956.3 GenPept UniProtKB/Swiss-Prot:Q92956

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