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MYH13 myosin heavy chain 13 [ Homo sapiens (human) ]

Gene ID: 8735, updated on 6-Sep-2022

Summary

Official Symbol
MYH13provided by HGNC
Official Full Name
myosin heavy chain 13provided by HGNC
Primary source
HGNC:HGNC:7571
See related
Ensembl:ENSG00000006788 MIM:603487; AllianceGenome:HGNC:7571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MyHC-eo; MyHC-IIL
Summary
Predicted to enable microfilament motor activity. Predicted to be involved in muscle contraction. Predicted to act upstream of or within cellular response to starvation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MYH13 in Genome Data Viewer
Location:
17p13.1
Exon count:
41
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (10300865..10373006, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (10208390..10280510, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10204182..10276323, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11916 Neighboring gene uncharacterized LOC107985004 Neighboring gene Sharpr-MPRA regulatory region 3410 Neighboring gene myosin heavy chain gene cluster antisense RNA Neighboring gene myosin heavy chain 8 Neighboring gene myosin heavy chain 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 protease cleaves human myosin heavy chain in vitro PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microfilament motor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle contraction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
part_of muscle myosin complex TAS
Traceable Author Statement
more info
PubMed 
located_in myofibril IEA
Inferred from Electronic Annotation
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myosin-13
Names
extraocular muscle myosin heavy chain
extraocular myosin heavy chain
myosin heavy chain, skeletal muscle, extraocular
myosin heavy chain, skeletal muscle, laryngeal
myosin, heavy chain 13, skeletal muscle
myosin, heavy polypeptide 13, skeletal muscle
superfast myosin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003802.3NP_003793.2  myosin-13

    See identical proteins and their annotated locations for NP_003793.2

    Status: VALIDATED

    Source sequence(s)
    AC005291, AF111782
    Consensus CDS
    CCDS45613.1
    UniProtKB/Swiss-Prot
    Q9P0U8, Q9UKX3
    Related
    ENSP00000252172.4, ENST00000252172.9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    10300865..10373006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    10208390..10280510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)