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RNMT RNA guanine-7 methyltransferase [ Homo sapiens (human) ]

Gene ID: 8731, updated on 8-Dec-2018

Summary

Official Symbol
RNMTprovided by HGNC
Official Full Name
RNA guanine-7 methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:10075
See related
Ensembl:ENSG00000101654 MIM:603514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1
Expression
Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See RNMT in Genome Data Viewer
Location:
18p11.21
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (13726645..13764556)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13726659..13764555)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene microRNA 4526 Neighboring gene family with sequence similarity 210 member A Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene melanocortin 5 receptor Neighboring gene melanocortin 2 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystem (from REACTOME)
    RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystemTo facilitate co-transcriptional capping, and thereby restrict the cap structure to RNAs made by RNA polymerase II, the capping enzymes bind directly to the RNA polymerase II. The C-terminal domain ...
  • RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, organism-specific biosystem (from REACTOME)
    RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, organism-specific biosystemTo facilitate co-transcriptional capping, and thereby restrict the cap structure to RNAs made by RNA polymerase II, the capping enzymes bind directly to the RNA polymerase II. The C-terminal domain ...
  • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase II Transcription, organism-specific biosystem
    RNA Polymerase II Transcription
  • Transcription of the HIV genome, organism-specific biosystem (from REACTOME)
    Transcription of the HIV genome, organism-specific biosystemExpression of the integrated HIV-1 provirus is dependent on the host cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. The long terminal repeats (L...
  • mRNA Capping, organism-specific biosystem (from REACTOME)
    mRNA Capping, organism-specific biosystemThe 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. The cap is thought to influence splicing of the first intron, and is bound by 'cap-binding' proteins, CBP80 a...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0398, DKFZp686H1252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
7-methylguanosine mRNA capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
RNA 5'-cap (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
fibrillar center IDA
Inferred from Direct Assay
more info
 
mRNA cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA cap binding complex IDA
Inferred from Direct Assay
more info
PubMed 
mRNA cap methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mRNA cap guanine-N7 methyltransferase
Names
RNA (guanine-7-) methyltransferase
hcm1p
mRNA (guanine-7-)methyltransferase
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase
NP_001295192.1
NP_003790.1
XP_005258219.1
XP_011524051.1
XP_011524052.1
XP_011524053.1
XP_011524055.1
XP_016881550.1
XP_024307048.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308263.1NP_001295192.1  mRNA cap guanine-N7 methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001295192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB022605, AK292561, AP001525, DA634865
    Consensus CDS
    CCDS77156.1
    UniProtKB/Swiss-Prot
    O43148
    UniProtKB/TrEMBL
    A8K946
    Related
    ENSP00000466111.1, ENST00000592764.5
    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136466
    Pox_MCEL; mRNA capping enzyme
  2. NM_003799.2NP_003790.1  mRNA cap guanine-N7 methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_003790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' terminal exon, and differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB022605, AF067791, AP001525, DA634865
    Consensus CDS
    CCDS11867.1
    UniProtKB/Swiss-Prot
    O43148
    Related
    ENSP00000372804.2, ENST00000383314.6
    Conserved Domains (1) summary
    pfam03291
    Location:136475
    Pox_MCEL; mRNA capping enzyme

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    13726645..13764556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451280.1XP_024307048.1  mRNA cap guanine-N7 methyltransferase isoform X5

    Related
    ENSP00000467171.1, ENST00000588457.5
    Conserved Domains (1) summary
    cl17173
    Location:1297
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011525753.2XP_011524055.1  mRNA cap guanine-N7 methyltransferase isoform X4

    Conserved Domains (2) summary
    COG0500
    Location:18149
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:1290
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_005258162.1XP_005258219.1  mRNA cap guanine-N7 methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_005258219.1

    UniProtKB/Swiss-Prot
    O43148
    Related
    ENSP00000446426.1, ENST00000543302.6
    Conserved Domains (1) summary
    pfam03291
    Location:136475
    Pox_MCEL; mRNA capping enzyme
  4. XM_017026061.1XP_016881550.1  mRNA cap guanine-N7 methyltransferase isoform X2

    UniProtKB/Swiss-Prot
    O43148
    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136466
    Pox_MCEL; mRNA capping enzyme
  5. XM_011525751.1XP_011524053.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011524053.1

    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136468
    Pox_MCEL; mRNA capping enzyme
  6. XM_011525749.2XP_011524051.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011524051.1

    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136468
    Pox_MCEL; mRNA capping enzyme
  7. XM_011525750.2XP_011524052.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011524052.1

    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136468
    Pox_MCEL; mRNA capping enzyme

RNA

  1. XR_001753297.1 RNA Sequence

  2. XR_001753296.2 RNA Sequence

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