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RNMT RNA guanine-7 methyltransferase [ Homo sapiens (human) ]

Gene ID: 8731, updated on 24-Nov-2020

Summary

Official Symbol
RNMTprovided by HGNC
Official Full Name
RNA guanine-7 methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:10075
See related
Ensembl:ENSG00000101654 MIM:603514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1
Expression
Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See RNMT in Genome Data Viewer
Location:
18p11.21
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (13726645..13764556)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13726659..13764555)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene microRNA 4526 Neighboring gene family with sequence similarity 210 member A Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene melanocortin 5 receptor Neighboring gene melanocortin 2 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0398, DKFZp686H1252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA (guanine-N7-)-methyltransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
7-methylguanosine mRNA capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
RNA 5'-cap (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
fibrillar center IDA
Inferred from Direct Assay
more info
 
mRNA cap binding complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA cap binding complex IDA
Inferred from Direct Assay
more info
PubMed 
mRNA cap methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mRNA cap guanine-N7 methyltransferase
Names
RNA (guanine-7-) methyltransferase
hcm1p
mRNA (guanine-7-)methyltransferase
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase
NP_001295192.1
NP_001365061.1
NP_001365063.1
NP_001365064.1
NP_003790.1
XP_011524051.1
XP_011524052.1
XP_011524053.1
XP_011524055.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308263.2NP_001295192.1  mRNA cap guanine-N7 methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001295192.1

    Status: VALIDATED

    Source sequence(s)
    AB022605, AK292561, AP001525, DA634865
    Consensus CDS
    CCDS77156.1
    UniProtKB/Swiss-Prot
    O43148
    UniProtKB/TrEMBL
    A8K946
    Related
    ENSP00000466111.1, ENST00000592764.5
    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136466
    Pox_MCEL; mRNA capping enzyme
  2. NM_001378132.1NP_001365061.1  mRNA cap guanine-N7 methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001525
    Related
    ENSP00000467171.1, ENST00000588457.5
  3. NM_001378134.1NP_001365063.1  mRNA cap guanine-N7 methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001525
  4. NM_001378135.1NP_001365064.1  mRNA cap guanine-N7 methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001525
    Related
    ENSP00000446426.1, ENST00000543302.6
  5. NM_003799.3NP_003790.1  mRNA cap guanine-N7 methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_003790.1

    Status: VALIDATED

    Source sequence(s)
    AB022605, AF067791, AP001525, DA634865
    Consensus CDS
    CCDS11867.1
    UniProtKB/Swiss-Prot
    O43148
    Related
    ENSP00000372804.2, ENST00000383314.6
    Conserved Domains (1) summary
    pfam03291
    Location:136475
    Pox_MCEL; mRNA capping enzyme

RNA

  1. NR_165427.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001525

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    13726645..13764556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525753.2XP_011524055.1  mRNA cap guanine-N7 methyltransferase isoform X4

    Conserved Domains (2) summary
    COG0500
    Location:18149
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:1290
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011525751.1XP_011524053.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011524053.1

    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136468
    Pox_MCEL; mRNA capping enzyme
  3. XM_011525749.2XP_011524051.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011524051.1

    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136468
    Pox_MCEL; mRNA capping enzyme
  4. XM_011525750.2XP_011524052.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011524052.1

    Conserved Domains (2) summary
    COG0500
    Location:196414
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam03291
    Location:136468
    Pox_MCEL; mRNA capping enzyme

RNA

  1. XR_001753297.1 RNA Sequence

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