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Rnmt RNA (guanine-7-) methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 67897, updated on 7-Apr-2025

Summary

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Official Symbol
Rnmtprovided by MGI
Official Full Name
RNA (guanine-7-) methyltransferaseprovided by MGI
Primary source
MGI:MGI:1915147
See related
Ensembl:ENSMUSG00000009535 AllianceGenome:MGI:1915147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rg7mt1; mKIAA0398; 2610002P10Rik
Summary
Predicted to enable RNA binding activity and mRNA 5'-cap (guanine-N7-)-methyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of mRNA cap methyltransferase RNMT:RAMAC complex; mRNA capping enzyme complex; and receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and skin. Orthologous to human RNMT (RNA guanine-7 methyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in CNS E18 (RPKM 9.2), CNS E14 (RPKM 8.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Rnmt in Genome Data Viewer
Location:
18 E2; 18 41.22 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (68433406..68457923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (68300233..68324852)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9174 Neighboring gene STARR-seq mESC enhancer starr_44926 Neighboring gene family with sequence similarity 210, member A Neighboring gene microRNA 7219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:68459940-68460049 Neighboring gene STARR-seq mESC enhancer starr_44927 Neighboring gene predicted gene, 54023 Neighboring gene melanocortin 5 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation. Galloway A, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34125914, Free PMC Article
  2. 5,10-Methylenetetrahydrofolate reductase becomes phosphorylated during meiotic maturation in mouse oocytes. Young K, et al. Zygote, 2022 Oct. PMID 35652653
  3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  4. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
  5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation.
    Title: Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 7-methylguanosine mRNA capping ISO
Inferred from Sequence Orthology
more info
  
involved_in 7-methylguanosine mRNA capping ISO
Inferred from Sequence Orthology
more info
  
involved_in 7-methylguanosine mRNA capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RNA 5'-cap (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cap methyltransferase RNMT:RAMAC complex ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cap methyltransferase RNMT:RAMAC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mRNA capping enzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA capping enzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mRNA cap guanine-N(7) methyltransferase; mRNA cap guanine-N7 methyltransferase
Names
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase
NP_001164424.1
NP_001347931.1
NP_001347932.1
NP_080716.1
XP_006526256.1
XP_006526260.1
XP_011245293.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170953.1 → NP_001164424.1  mRNA cap guanine-N(7) methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001164424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC111069, AK129130, CO039099
    Consensus CDS
    CCDS50314.1
    UniProtKB/Swiss-Prot
    Q9D0L8
    Related
    ENSMUSP00000025427.8, ENSMUST00000025427.14
    Conserved Domains (2) summary
    COG0500
    Location:160 → 335
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:125 → 409
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001361002.1 → NP_001347931.1  mRNA cap guanine-N(7) methyltransferase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 3 and 4 encode the same protein.
    Source sequence(s)
    AC111069
    Consensus CDS
    CCDS37852.1
    UniProtKB/Swiss-Prot
    Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
    Conserved Domains (1) summary
    pfam03291
    Location:125 → 464
    Pox_MCEL; mRNA capping enzyme

  3. NM_001361003.1 → NP_001347932.1  mRNA cap guanine-N(7) methyltransferase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 3 and 4 encode the same protein.
    Source sequence(s)
    AC111069
    Consensus CDS
    CCDS37852.1
    UniProtKB/Swiss-Prot
    Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
    Conserved Domains (1) summary
    pfam03291
    Location:125 → 464
    Pox_MCEL; mRNA capping enzyme

  4. NM_026440.4 → NP_080716.1  mRNA cap guanine-N(7) methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_080716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 3 and 4 encode the same protein.
    Source sequence(s)
    AC111069, AK129130, CO039099
    Consensus CDS
    CCDS37852.1
    UniProtKB/Swiss-Prot
    Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
    Related
    ENSMUSP00000009679.5, ENSMUST00000009679.11
    Conserved Domains (1) summary
    pfam03291
    Location:125 → 464
    Pox_MCEL; mRNA capping enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    68433406..68457923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246991.4 → XP_011245293.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011245293.1

    UniProtKB/Swiss-Prot
    Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
    Conserved Domains (1) summary
    pfam03291
    Location:125 → 464
    Pox_MCEL; mRNA capping enzyme

  2. XM_006526193.5 → XP_006526256.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006526256.1

    UniProtKB/Swiss-Prot
    Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
    Conserved Domains (1) summary
    pfam03291
    Location:125 → 464
    Pox_MCEL; mRNA capping enzyme

  3. XM_006526197.5 → XP_006526260.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006526260.1

    UniProtKB/Swiss-Prot
    Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
    Conserved Domains (1) summary
    pfam03291
    Location:125 → 464
    Pox_MCEL; mRNA capping enzyme

RNA

  1. XR_004939884.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0L8.1 GenPept UniProtKB/Swiss-Prot:Q9D0L8

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