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CBR1 carbonyl reductase 1 [ Homo sapiens (human) ]

Gene ID: 873, updated on 27-Jun-2020

Summary

Official Symbol
CBR1provided by HGNC
Official Full Name
carbonyl reductase 1provided by HGNC
Primary source
HGNC:HGNC:1548
See related
Ensembl:ENSG00000159228 MIM:114830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBR; hCBR1; PG-9-KR; SDR21C1
Summary
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Broad expression in duodenum (RPKM 163.2), small intestine (RPKM 98.7) and 19 other tissues See more
Orthologs

Genomic context

See CBR1 in Genome Data Viewer
Location:
21q22.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (36070024..36073164)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37442285..37445462)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene SET domain containing 4 Neighboring gene ribosomal modification protein rimK like family member B pseudogene 1 Neighboring gene SETD4 antisense RNA 1 Neighboring gene uncharacterized LOC100133286 Neighboring gene RNA, U6 small nuclear 992, pseudogene Neighboring gene uncharacterized LOC105369306 Neighboring gene CBR3 antisense RNA 1 Neighboring gene mediator of cell motility 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
15-hydroxyprostaglandin dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
15-hydroxyprostaglandin dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
androstan-3-alpha,17-beta-diol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-E2 9-reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin-E2 9-reductase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
vitamin K metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular vesicle HDA PubMed 

General protein information

Preferred Names
carbonyl reductase [NADPH] 1
Names
15-hydroxyprostaglandin dehydrogenase
20-beta-hydroxysteroid dehydrogenase
NADPH-dependent carbonyl reductase 1
carbonyl reductase (NADPH) 1
epididymis secretory sperm binding protein
prostaglandin 9-ketoreductase
prostaglandin-E(2) 9-reductase
short chain dehydrogenase/reductase family 21C member 1
NP_001273718.1
NP_001748.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286789.2NP_001273718.1  carbonyl reductase [NADPH] 1 isoform 2

    See identical proteins and their annotated locations for NP_001273718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon that causes a frame-shift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK294142, AK311219
    Consensus CDS
    CCDS68202.1
    UniProtKB/Swiss-Prot
    P16152
    Related
    ENSP00000434613.1, ENST00000530908.5
    Conserved Domains (1) summary
    cl21454
    Location:6131
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001757.4NP_001748.1  carbonyl reductase [NADPH] 1 isoform 1

    See identical proteins and their annotated locations for NP_001748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB124848
    Consensus CDS
    CCDS13641.1
    UniProtKB/Swiss-Prot
    P16152
    Related
    ENSP00000290349.6, ENST00000290349.11
    Conserved Domains (1) summary
    cd05324
    Location:6277
    carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    36070024..36073164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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