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Cbr1 carbonyl reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 12408, updated on 1-Mar-2024

Summary

Official Symbol
Cbr1provided by MGI
Official Full Name
carbonyl reductase 1provided by MGI
Primary source
MGI:MGI:88284
See related
Ensembl:ENSMUSG00000051483 AllianceGenome:MGI:88284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR; Cbr; PG-9-KR
Summary
Predicted to enable carbonyl reductase (NADPH) activity and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Predicted to be involved in several processes, including phylloquinone catabolic process; prostaglandin catabolic process; and response to progesterone. Part of subapical complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human CBR1 (carbonyl reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 160.7), duodenum adult (RPKM 131.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cbr1 in Genome Data Viewer
Location:
16 C4; 16 54.53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (93404752..93407226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (93607837..93610349)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41530 Neighboring gene STARR-seq mESC enhancer starr_41531 Neighboring gene predicted gene, 30695 Neighboring gene STARR-seq mESC enhancer starr_41532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:93572605-93572851 Neighboring gene STARR-seq mESC enhancer starr_41534 Neighboring gene SET domain containing 4 Neighboring gene STARR-positive B cell enhancer mm9_chr16:93607761-93608062 Neighboring gene carbonyl reductase 1B Neighboring gene carbonyl reductase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carbonyl reductase [NADPH] 1
Names
15-hydroxyprostaglandin dehydrogenase
20-beta-hydroxysteroid dehydrogenase
Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1)
NADPH-dependent carbonyl reductase 1
alcohol dehydrogenase [NAD(P)+] CBR1
prostaglandin 9-ketoreductase
prostaglandin-E(2) 9-reductase
NP_031646.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007620.3NP_031646.2  carbonyl reductase [NADPH] 1

    See identical proteins and their annotated locations for NP_031646.2

    Status: VALIDATED

    Source sequence(s)
    AC160993
    Consensus CDS
    CCDS28341.1
    UniProtKB/Swiss-Prot
    P48758, Q91X28
    UniProtKB/TrEMBL
    B2RXY7
    Related
    ENSMUSP00000049394.9, ENSMUST00000039659.9
    Conserved Domains (2) summary
    cd05324
    Location:7277
    carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs
    pfam00106
    Location:7239
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    93404752..93407226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)