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TRADD TNFRSF1A associated via death domain [ Homo sapiens (human) ]

Gene ID: 8717, updated on 21-Dec-2019

Summary

Official Symbol
TRADDprovided by HGNC
Official Full Name
TNFRSF1A associated via death domainprovided by HGNC
Primary source
HGNC:HGNC:12030
See related
Ensembl:ENSG00000102871 MIM:603500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hs.89862
Summary
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See TRADD in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67154185..67159909, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67188088..67193812, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene core-binding factor subunit beta Neighboring gene chromosome 16 open reading frame 70 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene KIAA0895 like Neighboring gene nucleolar protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
death domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
death-inducing signaling complex assembly TAS
Traceable Author Statement
more info
 
extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
death-inducing signaling complex TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor receptor type 1-associated DEATH domain protein
Names
TNFR1-associated death domain protein
tumor necrosis factor receptor type 1 associated death domain protein
tumor necrosis factor receptor-1-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323552.2NP_001310481.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

    Status: REVIEWED

    Source sequence(s)
    AC074143, BT006934, CA426418, DA353575
    Consensus CDS
    CCDS10829.1
    UniProtKB/Swiss-Prot
    Q15628
    Conserved Domains (2) summary
    pfam09034
    Location:51160
    TRADD_N; TRADD, N-terminal domain
    cl14633
    Location:215304
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_003789.4NP_003780.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

    See identical proteins and their annotated locations for NP_003780.1

    Status: REVIEWED

    Source sequence(s)
    BC004491, CA426418, DA353575
    Consensus CDS
    CCDS10829.1
    UniProtKB/Swiss-Prot
    Q15628
    Related
    ENSP00000341268.4, ENST00000345057.9
    Conserved Domains (2) summary
    pfam09034
    Location:51160
    TRADD_N; TRADD, N-terminal domain
    cl14633
    Location:215304
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67154185..67159909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256213.4XP_005256270.1  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2

    See identical proteins and their annotated locations for XP_005256270.1

    UniProtKB/Swiss-Prot
    Q15628
    Related
    ENSP00000462591.1, ENST00000486556.1
    Conserved Domains (2) summary
    pfam09034
    Location:1100
    TRADD_N; TRADD, N-terminal domain
    cl14633
    Location:155244
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. XM_017023815.1XP_016879304.1  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1

    UniProtKB/Swiss-Prot
    Q15628
    Conserved Domains (2) summary
    pfam09034
    Location:51160
    TRADD_N; TRADD, N-terminal domain
    cl14633
    Location:215304
    DD; Death Domain Superfamily of protein-protein interaction domains

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153425.1: Suppressed sequence

    Description
    NM_153425.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript variant.
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