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HYAL2 hyaluronidase 2 [ Homo sapiens (human) ]

Gene ID: 8692, updated on 15-Apr-2019

Summary

Official Symbol
HYAL2provided by HGNC
Official Full Name
hyaluronidase 2provided by HGNC
Primary source
HGNC:HGNC:5321
See related
Ensembl:ENSG00000068001 MIM:603551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LUCA2
Summary
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]
Expression
Broad expression in spleen (RPKM 78.9), lung (RPKM 35.1) and 20 other tissues See more
Orthologs

Genomic context

See HYAL2 in Genome Data Viewer
Location:
3p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (50317790..50322850, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50355221..50360281, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hyaluronidase 3 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronidase 1 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene Ras association domain family member 1 Neighboring gene RASSF1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
hyaluronic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
hyaluronoglucuronidase activity IDA
Inferred from Direct Assay
more info
PubMed 
hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
hyalurononglucosaminidase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling protein tyrosine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
fusion of virus membrane with host plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
glycosaminoglycan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hyaluronan catabolic process TAS
Traceable Author Statement
more info
 
kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
monocyte activation IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism aging IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of urine volume ISS
Inferred from Sequence or Structural Similarity
more info
 
renal water absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
transformation of host cell by virus IDA
Inferred from Direct Assay
more info
PubMed 
transformation of host cell by virus ISS
Inferred from Sequence or Structural Similarity
more info
 
viral entry into host cell ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hyaluronidase-2
Names
PH-20 homolog
PH20 homolog
hyal-2
hyaluronoglucosaminidase 2
lung carcinoma protein 2
lysosomal hyaluronidase
NP_003764.3
NP_149348.2
XP_005265581.1
XP_005265582.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003773.5NP_003764.3  hyaluronidase-2 precursor

    See identical proteins and their annotated locations for NP_003764.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK127945, DC358776, U09577
    Consensus CDS
    CCDS2818.1
    UniProtKB/Swiss-Prot
    Q12891
    Related
    ENSP00000350387.4, ENST00000357750.9
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
  2. NM_033158.4NP_149348.2  hyaluronidase-2 precursor

    See identical proteins and their annotated locations for NP_149348.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK092449, AK127945, DC358776, U09577
    Consensus CDS
    CCDS2818.1
    UniProtKB/Swiss-Prot
    Q12891
    Related
    ENSP00000406657.1, ENST00000442581.1
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    50317790..50322850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265524.2XP_005265581.1  hyaluronidase-2 isoform X1

    See identical proteins and their annotated locations for XP_005265581.1

    UniProtKB/Swiss-Prot
    Q12891
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
  2. XM_005265525.2XP_005265582.1  hyaluronidase-2 isoform X1

    See identical proteins and their annotated locations for XP_005265582.1

    UniProtKB/Swiss-Prot
    Q12891
    Related
    ENSP00000401853.1, ENST00000447092.5
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
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