U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hyal2 hyaluronoglucosaminidase 2 [ Mus musculus (house mouse) ]

Gene ID: 15587, updated on 26-Sep-2022

Summary

Official Symbol
Hyal2provided by MGI
Official Full Name
hyaluronoglucosaminidase 2provided by MGI
Primary source
MGI:MGI:1196334
See related
Ensembl:ENSMUSG00000010047 AllianceGenome:MGI:1196334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables enzyme binding activity; transforming growth factor beta binding activity; and virus receptor activity. Contributes to transcription coactivator activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; defense response to virus; and positive regulation of protein import into nucleus. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; multicellular organismal iron ion homeostasis; and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface and membrane raft. Is anchored component of plasma membrane. Part of RNA polymerase II transcription regulator complex. Colocalizes with anchored component of external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; lateral plate mesoderm; and respiratory system. Orthologous to human HYAL2 (hyaluronidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 54.9), duodenum adult (RPKM 43.5) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hyal2 in Genome Data Viewer
Location:
9 F1; 9 58.12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107445085..107449977)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107567873..107572778)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 1 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronoglucosaminidase 1 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronoglucosaminidase 3 Neighboring gene interferon-related developmental regulator 2 Neighboring gene leucine-rich single-pass membrane protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables hyaluronic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables hyaluronoglucuronidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hyaluronoglucuronidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hyalurononglucosaminidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hyalurononglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hyalurononglucosaminidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables receptor signaling protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transforming growth factor beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fusion of virus membrane with host plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in glycosaminoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaluronan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hyaluronan catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaluronan catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in monocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within multicellular organism aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane raft ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hyaluronidase-2
Names
hyal-2
NP_034619.2
XP_006511706.1
XP_006511707.1
XP_036010506.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409671.1NP_001396600.1  hyaluronidase-2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672219
  2. NM_001409672.1NP_001396601.1  hyaluronidase-2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672219
  3. NM_010489.3NP_034619.2  hyaluronidase-2 precursor

    See identical proteins and their annotated locations for NP_034619.2

    Status: VALIDATED

    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS23496.1
    UniProtKB/Swiss-Prot
    O35632, Q99MT0
    UniProtKB/TrEMBL
    Q3UZE4
    Related
    ENSMUSP00000010191.8, ENSMUST00000010191.13
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107445085..107449977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511644.5XP_006511707.1  hyaluronidase-2 isoform X1

    UniProtKB/Swiss-Prot
    O35632, Q99MT0
    UniProtKB/TrEMBL
    Q3UZE4
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
  2. XM_036154613.1XP_036010506.1  hyaluronidase-2 isoform X1

    UniProtKB/Swiss-Prot
    Q99MT0
    UniProtKB/TrEMBL
    Q3UZE4
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
  3. XM_006511643.5XP_006511706.1  hyaluronidase-2 isoform X1

    See identical proteins and their annotated locations for XP_006511706.1

    UniProtKB/Swiss-Prot
    O35632, Q99MT0
    UniProtKB/TrEMBL
    Q3UZE4
    Related
    ENSMUSP00000141280.2, ENSMUST00000195752.6
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase