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Hyal2 hyaluronoglucosaminidase 2 [ Mus musculus (house mouse) ]

Gene ID: 15587, updated on 22-May-2018
Official Symbol
Hyal2provided by MGI
Official Full Name
hyaluronoglucosaminidase 2provided by MGI
Primary source
MGI:MGI:1196334
See related
Ensembl:ENSMUSG00000010047 Vega:OTTMUSG00000050817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI256841; AU020858; AW555733
Expression
Ubiquitous expression in lung adult (RPKM 54.9), duodenum adult (RPKM 43.5) and 24 other tissues See more
Orthologs
See Hyal2 in Genome Data Viewer
Location:
9 F1; 9 58.12 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (107567886..107572778)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107471494..107475109)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 1 Neighboring gene tumor suppressor candidate 2 Neighboring gene hyaluronoglucosaminidase 1 Neighboring gene N-acetyltransferase 6 Neighboring gene hyaluronoglucosaminidase 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
hyaluronic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
hyaluronoglucuronidase activity ISO
Inferred from Sequence Orthology
more info
 
hyalurononglucosaminidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
fusion of virus membrane with host plasma membrane ISO
Inferred from Sequence Orthology
more info
 
glycosaminoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
hyaluronan catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
monocyte activation ISO
Inferred from Sequence Orthology
more info
 
monocyte activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
multicellular organism aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 secretion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 secretion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
response to virus ISO
Inferred from Sequence Orthology
more info
 
skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transformation of host cell by virus ISO
Inferred from Sequence Orthology
more info
 
viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with anchored component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
microvillus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
hyaluronidase-2
Names
hyal-2
NP_034619.2
XP_006511706.1
XP_006511707.1
XP_006511708.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010489.2NP_034619.2  hyaluronidase-2 precursor

    See identical proteins and their annotated locations for NP_034619.2

    Status: PROVISIONAL

    Source sequence(s)
    AF422177
    Consensus CDS
    CCDS23496.1
    UniProtKB/Swiss-Prot
    O35632
    UniProtKB/TrEMBL
    Q3UZE4
    Related
    ENSMUSP00000010191.7, ENSMUST00000010191.12
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    107567886..107572778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511644.3XP_006511707.1  hyaluronidase-2 isoform X1

    See identical proteins and their annotated locations for XP_006511707.1

    UniProtKB/Swiss-Prot
    O35632
    UniProtKB/TrEMBL
    Q3UZE4
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
  2. XM_006511643.3XP_006511706.1  hyaluronidase-2 isoform X1

    See identical proteins and their annotated locations for XP_006511706.1

    UniProtKB/Swiss-Prot
    O35632
    UniProtKB/TrEMBL
    Q3UZE4
    Related
    ENSMUSP00000141280.1, OTTMUSP00000069249, ENSMUST00000195752.5, OTTMUST00000128771
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
  3. XM_006511645.3XP_006511708.1  hyaluronidase-2 isoform X1

    See identical proteins and their annotated locations for XP_006511708.1

    UniProtKB/Swiss-Prot
    O35632
    UniProtKB/TrEMBL
    Q3UZE4
    Conserved Domains (1) summary
    pfam01630
    Location:29358
    Glyco_hydro_56; Hyaluronidase
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