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PEA15 proliferation and apoptosis adaptor protein 15 [ Homo sapiens (human) ]

Gene ID: 8682, updated on 1-Jun-2020

Summary

Official Symbol
PEA15provided by HGNC
Official Full Name
proliferation and apoptosis adaptor protein 15provided by HGNC
Primary source
HGNC:HGNC:8822
See related
Ensembl:ENSG00000162734 MIM:603434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15
Summary
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Broad expression in brain (RPKM 413.0), fat (RPKM 91.8) and 18 other tissues See more
Orthologs

Genomic context

See PEA15 in Genome Data Viewer
Location:
1q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (160205384..160215376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160175125..160185162)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 4 Neighboring gene calsequestrin 1 Neighboring gene uncharacterized LOC729867 Neighboring gene DDB1 and CUL4 associated factor 8 Neighboring gene uncharacterized LOC100287049 Neighboring gene ribosomal protein SA pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
microtubule associated complex NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
astrocytic phosphoprotein PEA-15
Names
15 kDa phosphoprotein enriched in astrocytes
homolog of mouse MAT-1 oncogene
mammary transforming gene 1, mouse, homolog of
phosphoprotein enriched in astrocytes 15
phosphoprotein enriched in diabetes
proliferation and apoptosis adaptor 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297576.2NP_001284505.1  astrocytic phosphoprotein PEA-15 isoform a

    See identical proteins and their annotated locations for NP_001284505.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK095879, AL121987, BC010469, BC022554, DA131259
    Consensus CDS
    CCDS72954.1
    UniProtKB/Swiss-Prot
    Q15121
    UniProtKB/TrEMBL
    Q96FS5
    Related
    ENSP00000357055.1, ENST00000368076.1
    Conserved Domains (1) summary
    cd08338
    Location:23106
    DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15
  2. NM_001297577.2NP_001284506.1  astrocytic phosphoprotein PEA-15 isoform b

    See identical proteins and their annotated locations for NP_001284506.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    BC010469, BC022554, DA131259, DA707281
    Consensus CDS
    CCDS1199.1
    UniProtKB/Swiss-Prot
    Q15121
    UniProtKB/TrEMBL
    B1AKZ4, Q96FS5
    Conserved Domains (1) summary
    cd08338
    Location:285
    DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15
  3. NM_001297578.2NP_001284507.1  astrocytic phosphoprotein PEA-15 isoform c

    See identical proteins and their annotated locations for NP_001284507.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate in-frame splice site in the 5' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AL121987, BC010469, BC022554, DA157938
    Consensus CDS
    CCDS76227.1
    UniProtKB/Swiss-Prot
    Q15121
    UniProtKB/TrEMBL
    B1AKZ5, Q96FS5
    Related
    ENSP00000357056.1, ENST00000368077.5
    Conserved Domains (1) summary
    cl14633
    Location:263
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. NM_003768.5NP_003759.1  astrocytic phosphoprotein PEA-15 isoform b

    See identical proteins and their annotated locations for NP_003759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    BC002426, BC010469, BC022554, DA131259
    Consensus CDS
    CCDS1199.1
    UniProtKB/Swiss-Prot
    Q15121
    UniProtKB/TrEMBL
    B1AKZ4, Q96FS5
    Related
    ENSP00000353660.4, ENST00000360472.8
    Conserved Domains (1) summary
    cd08338
    Location:285
    DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15

RNA

  1. NR_123724.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    BC010469, BC022554, DA131259, DA538845

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    160205384..160215376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711599.3XP_006711662.1  astrocytic phosphoprotein PEA-15 isoform X1

    See identical proteins and their annotated locations for XP_006711662.1

    UniProtKB/Swiss-Prot
    Q15121
    UniProtKB/TrEMBL
    B1AKZ4
    Conserved Domains (1) summary
    cd08338
    Location:285
    DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15
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