Pea15a proliferation and apoptosis adaptor protein 15A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pea15aprovided by MGI
Official Full Name: proliferation and apoptosis adaptor protein 15Aprovided by MGI
Primary source: MGI:MGI:104799
See related: Ensembl:ENSMUSG00000013698 AllianceGenome:MGI:104799
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mat1; Pea15; PEA-15; Pkcs15
Summary: This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression: Broad expression in cerebellum adult (RPKM 121.2), frontal lobe adult (RPKM 117.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172024295..172034371, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172196728..172206804, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion.
Title: Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion.
these data raise the prospect that PEA-15 functions as a key regulator of the Suprachiasmatic nucleus timing system.
Title: Circadian expression and functional characterization of PEA-15 within the mouse suprachiasmatic nucleus.
this study shows that PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models
Title: PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models.
Epigenetic changes imposed at this region by diets, which impair glucose tolerance generate metabolic memory of the nutritional injury and leave Ped/Pea-15 induction in a poised state.
Title: High-fat diet unveils an enhancer element at the Ped/Pea-15 gene responsible for epigenetic memory in skeletal muscle.
Under conditions of reduced glucose, the PS1/gamma-secretase system decreases neuronal losses by suppressing miR-212 and increasing its target survival factor, PEA15. These observations have implications for mechanisms of neuronal death under conditions of reduced glucose and may provide targets for intervention in neurodegenerative disorders.
Title: Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15.
the neurological and neurochemical phenotype of transgenic mice overexpressing PED/PEA-15 (tgPED), were analyzed.
Title: Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice.
PEA-15 is a protective mediator in the vasculature and acts, at least in part, by inhibiting ERK1/2-dependent nuclear signaling in vascular smooth muscle cells during neointimal hyperplasia.
Title: PEA-15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia.
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Title: Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Title: PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1.
Activated astrocytes are known to clear the Abeta deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Title: Quantitative proteomics reveals that PEA15 regulates astroglial Aβ phagocytosis in an Alzheimer's disease mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pea15 (e-PCR), detects polymorphism
- UniSTS:144159

AI323543 (e-PCR)
- UniSTS:178517

D10Bir17 (e-PCR), detects polymorphism
- UniSTS:141482

G49234 (e-PCR)
- UniSTS:108990

Homology

Homologs of the Pea15a gene: The Pea15a gene is conserved in human, chimpanzee, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 432 organisms have orthologs with human gene Pea15a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase C binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: astrocytic phosphoprotein PEA-15

Names: 15 kDa phosphoprotein enriched in astrocytes; mammary transforming gene 1; phosphoprotein enriched in astrocytes 15; phosphoprotein enriched in astrocytes 15A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329869.1 → NP_001316798.1 astrocytic phosphoprotein PEA-15 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2). Both variants 2 and 3 encode the same protein.

Source sequence(s)

AC074310, AK153141, BE992884

Consensus CDS

CCDS15510.1

UniProtKB/Swiss-Prot

Q3U5N7, Q62048

Conserved Domains (1) summary

cd08338
Location:2 → 85

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15
NM_001329871.1 → NP_001316800.1 astrocytic phosphoprotein PEA-15 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 2. The resulting isoform (3) has a shorter N-terminus compared to isoform 2.

Source sequence(s)

AC074310, AK153141, BE992884, CD807366

Consensus CDS

CCDS87924.1

UniProtKB/Swiss-Prot

Q62048

Related

ENSMUSP00000106878.2, ENSMUST00000111247.8

Conserved Domains (1) summary

cl14633
Location:2 → 63

DD; Death Domain Superfamily of protein-protein interaction domains
NM_011063.3 → NP_035193.1 astrocytic phosphoprotein PEA-15 isoform 2

See identical proteins and their annotated locations for NP_035193.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Both variants 2 and 3 encode the same protein.

Source sequence(s)

AC074310, AK153141, BE992884, BY278511

Consensus CDS

CCDS15510.1

UniProtKB/Swiss-Prot

Q3U5N7, Q62048

Related

ENSMUSP00000013842.6, ENSMUST00000013842.12

Conserved Domains (1) summary

cd08338
Location:2 → 85

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

172024295..172034371 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496702.2 → XP_006496765.1 astrocytic phosphoprotein PEA-15 isoform X1

See identical proteins and their annotated locations for XP_006496765.1

UniProtKB/Swiss-Prot

Q3U5N7, Q62048

Conserved Domains (1) summary

cd08338
Location:2 → 85

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_008556.1: Suppressed sequence

Description

NM_008556.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.