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EIF3J eukaryotic translation initiation factor 3 subunit J [ Homo sapiens (human) ]

Gene ID: 8669, updated on 13-Jun-2020

Summary

Official Symbol
EIF3Jprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Jprovided by HGNC
Primary source
HGNC:HGNC:3270
See related
Ensembl:ENSG00000104131 MIM:603910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3S1; eIF3-p35; eIF3-alpha
Summary
This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in appendix (RPKM 31.0), brain (RPKM 29.6) and 25 other tissues See more
Orthologs

Genomic context

See EIF3J in Genome Data Viewer
Location:
15q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (44537068..44562803)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44829266..44855001)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase like 2 Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene 1 Neighboring gene EIF3J divergent transcript Neighboring gene SPG11 vesicle trafficking associated, spatacsin Neighboring gene PAT1 homolog 2 Neighboring gene microRNA 10393 Neighboring gene beta-2-microglobulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit J
Names
eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284335.1NP_001271264.1  eukaryotic translation initiation factor 3 subunit J isoform 2

    See identical proteins and their annotated locations for NP_001271264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC009996, AK300659, BC002719, BU621047
    Consensus CDS
    CCDS61612.1
    UniProtKB/Swiss-Prot
    O75822
    Related
    ENSP00000440221.1, ENST00000535391.5
    Conserved Domains (1) summary
    pfam08597
    Location:12136
    eIF3_subunit; Translation initiation factor eIF3 subunit
  2. NM_001284336.1NP_001271265.1  eukaryotic translation initiation factor 3 subunit J isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC009996, AL536561, BC002719, BU621047
    Consensus CDS
    CCDS61613.1
    UniProtKB/Swiss-Prot
    O75822
    Related
    ENSP00000414548.3, ENST00000424492.7
    Conserved Domains (1) summary
    pfam08597
    Location:12209
    eIF3_subunit; Translation initiation factor eIF3 subunit
  3. NM_003758.4NP_003749.2  eukaryotic translation initiation factor 3 subunit J isoform 1

    See identical proteins and their annotated locations for NP_003749.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009996, BC002719, BU621047
    Consensus CDS
    CCDS10111.1
    UniProtKB/Swiss-Prot
    O75822
    UniProtKB/TrEMBL
    A0A024R5S5
    Related
    ENSP00000261868.5, ENST00000261868.10
    Conserved Domains (1) summary
    pfam08597
    Location:12258
    eIF3_subunit; Translation initiation factor eIF3 subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    44537068..44562803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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