Format

Send to:

Choose Destination

SOCS1 suppressor of cytokine signaling 1 [ Homo sapiens (human) ]

Gene ID: 8651, updated on 25-Oct-2020

Summary

Official Symbol
SOCS1provided by HGNC
Official Full Name
suppressor of cytokine signaling 1provided by HGNC
Primary source
HGNC:HGNC:19383
See related
Ensembl:ENSG00000185338 MIM:603597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; SOCS-1
Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 6.5), lymph node (RPKM 5.3) and 21 other tissues See more
Orthologs

Genomic context

See SOCS1 in Genome Data Viewer
Location:
16p13.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (11254417..11256182, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11348274..11350039, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr16.1224 Neighboring gene uncharacterized LOC105371082 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 4 Neighboring gene transition protein 2 Neighboring gene protamine 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
GeneReviews: Not available
Genetic variants associated with disordered eating.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-infected clinical samples upregulate SOCS1 expression in ex vivo cultures of monocyte derived dendritic cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced IL-23 upregulated SOCS1 protein in T cells, which inhibits IFN-gamma production and killing of CEF-pulsed monocytes PubMed
env SOCS1 protein expression is upregulated in T cells cultured with HIV-1 gp120-treated myeloid dendritic cell medium but is significantly inhibited in the presence of anti-IL-23 antibody PubMed
Nef nef HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors PubMed
Pr55(Gag) gag Both HIV-1 Gag/p24 and SOCS1 are detected in HIV-1 virus-like particles by Western assay, indicating that SOCS1 is incorporated into HIV-1 PubMed
gag The suppressor of cytokine signaling 1 (SOCS1) directly binds to the matrix and nucleocapsid regions of the HIV-1 p55 Gag and enhances its stability and trafficking, resulting in the efficient production of HIV-1 particles PubMed
Tat tat HIV-1 upregulates SOCS1 expression in human monocytes, dendritic cells and HEK-TLR4-MD2-CD14 cells via the N-terminal region including Tat 1-45 (Tat 3--72 fragment did not demonstrate this activity) PubMed
tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 1 (SOCS1) PubMed
capsid gag Both HIV-1 Gag/p24 and SOCS1 are detected in HIV-1 virus-like particles by Western assay, indicating that SOCS1 is incorporated into HIV-1 PubMed
matrix gag The suppressor of cytokine signaling 1 (SOCS1) directly binds to the matrix and nucleocapsid regions of the HIV-1 p55 Gag and enhances its stability and trafficking, resulting in the efficient production of HIV-1 particles PubMed
nucleocapsid gag The suppressor of cytokine signaling 1 (SOCS1) directly binds to the matrix and nucleocapsid regions of the HIV-1 p55 Gag and enhances its stability and trafficking, resulting in the efficient production of HIV-1 particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of CD8-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JAK-STAT cascade NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of CD4-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of activation of Janus kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
suppressor of cytokine signaling 1
Names
JAK binding protein
STAT induced SH3 protein 1
STAT-induced STAT inhibitor 1
Tec-interacting protein 3
cytokine-inducible SH2 protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003745.1NP_003736.1  suppressor of cytokine signaling 1

    See identical proteins and their annotated locations for NP_003736.1

    Status: REVIEWED

    Source sequence(s)
    AB000734
    Consensus CDS
    CCDS10546.1
    UniProtKB/Swiss-Prot
    O15524
    UniProtKB/TrEMBL
    Q4JHT5
    Related
    ENSP00000329418.2, ENST00000332029.3
    Conserved Domains (2) summary
    cd10382
    Location:68165
    SH2_SOCS1; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03735
    Location:169211
    SOCS_SOCS1; SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    11254417..11256182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center