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NCOA1 nuclear receptor coactivator 1 [ Homo sapiens (human) ]

Gene ID: 8648, updated on 6-Jan-2019

Summary

Official Symbol
NCOA1provided by HGNC
Official Full Name
nuclear receptor coactivator 1provided by HGNC
Primary source
HGNC:HGNC:7668
See related
Ensembl:ENSG00000084676 MIM:602691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74
Summary
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 17.5), testis (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See NCOA1 in Genome Data Viewer
Location:
2p23.3
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (24492050..24770702)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24714919..24993571)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene intersectin 2 Neighboring gene ribosomal protein L36a pseudogene 13 Neighboring gene uncharacterized LOC105374329 Neighboring gene RNA, 5S ribosomal pseudogene 88 Neighboring gene RNA, U6 small nuclear 936, pseudogene Neighboring gene uncharacterized LOC105369164 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene centromere protein O Neighboring gene adenylate cyclase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
tat HIV-1 Tat-induced calcium mobilization and TNF-alpha production in primary human monocytes are entirely regulated by DHP receptors PubMed
tat SRC1a binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
Vpr vpr HIV-1 Vpr synergistically enhances SRC-1 ligand activated glucocorticoid receptor activity, however Vpr does not bind to SRC-1 PubMed
matrix gag HIV-1 MA upregulates NCOA1 gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activation of gene expression by SREBF (SREBP), organism-specific biosystem (from REACTOME)
    Activation of gene expression by SREBF (SREBP), organism-specific biosystemAfter transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Bile acid and bile salt metabolism, organism-specific biosystem (from REACTOME)
    Bile acid and bile salt metabolism, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsi...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Constitutive Androstane Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Constitutive Androstane Receptor Pathway, organism-specific biosystemThe Constitutive Androstane Receptor (CAR) is a nuclear receptor and functions as a sensor for xenobiotics. It regulates transcription of genes encoding proteins in metabolism and excretion of xenobi...
  • Cytochrome P450 - arranged by substrate type, organism-specific biosystem (from REACTOME)
    Cytochrome P450 - arranged by substrate type, organism-specific biosystemThe P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate s...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Endogenous sterols, organism-specific biosystem (from REACTOME)
    Endogenous sterols, organism-specific biosystemA number of CYPs take part in cholesterol biosynthesis and elimination, thus playing an important role in maintaining cholesterol homeostasis. Under normal physiological conditions, cholesterol intak...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
    Glucocorticoid receptor regulatory network, organism-specific biosystem
    Glucocorticoid receptor regulatory network
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    HIF-1-alpha transcription factor network, organism-specific biosystem
    HIF-1-alpha transcription factor network
  • IL-6 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling pathway, organism-specific biosystemIL-6 is a pleiotropic cytokine with important role in immune regulation, hematopoiesis, inflammation and oncogenesis. IL-6-type cytokines exert their action via the signal transducer gp130 that assoc...
  • Leptin signaling pathway, organism-specific biosystem (from WikiPathways)
    Leptin signaling pathway, organism-specific biosystemLeptin is a peptide hormone mainly synthesised and secreted from adipocytes. It is also expressed in other tissues including placenta, stomach and skeletal muscle. Leptin mediates its effects by bind...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Mitochondrial biogenesis, organism-specific biosystemMitochondrial biogenesis and remodeling occur in response to exercise and redox state (reviewed in Scarpulla et al. 2012, Handy and Loscalzo 2012, Piantadosi and Suliman 2012, Scarpulla 2011, Wenz et...
  • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
    Notch-mediated HES/HEY network, organism-specific biosystem
    Notch-mediated HES/HEY network
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • RORA activates gene expression, organism-specific biosystem (from REACTOME)
    RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
  • RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem (from Pathway Interaction Database)
    RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem
    RXR and RAR heterodimerization with other nuclear receptor
  • Recycling of bile acids and salts, organism-specific biosystem (from REACTOME)
    Recycling of bile acids and salts, organism-specific biosystemOf the 20-40 grams of bile salts released daily by the liver, all but approximately 0.5 grams are reabsorbed from the intestine, returned to the liver, and re-used. This recycling involves a series o...
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity
  • Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
    Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystemSterol regulatory element binding proteins (SREBPs, SREBFs) respond to low cholesterol concentrations by transiting to the nucleus and activating genes involved in cholesterol and lipid biosynthesis ...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
    Regulation of nuclear SMAD2/3 signaling
  • Retinoic acid receptors-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    Retinoic acid receptors-mediated signaling, organism-specific biosystem
    Retinoic acid receptors-mediated signaling
  • Synthesis of bile acids and bile salts, organism-specific biosystem (from REACTOME)
    Synthesis of bile acids and bile salts, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily (Russell 2003). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol...
  • Synthesis of bile acids and bile salts via 27-hydroxycholesterol, organism-specific biosystem (from REACTOME)
    Synthesis of bile acids and bile salts via 27-hydroxycholesterol, organism-specific biosystemIn the body, 27-hydroxycholesterol is synthesized in multiple tissues, exported to the liver, and converted there to bile acids and bile salts. This pathway is only a minor source of bile acids and b...
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, organism-specific biosystem (from REACTOME)
    Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, organism-specific biosystemIn the liver, synthesis of bile acids and bile salts is initiated with the conversion of cholesterol to 7alpha-hydroxycholesterol and of 7alpha-hydroxycholesterol to 4-cholesten-7alpha-ol-3-one. The ...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Transcriptional activation of mitochondrial biogenesis, organism-specific biosystemPhosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
    YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129719, MGC129720

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
progesterone receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
retinoid X receptor binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
cellular response to Thyroglobulin triiodothyronine IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
histone H4 acetylation IEA
Inferred from Electronic Annotation
more info
 
hypothalamus development IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male mating behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter by galactose IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of thyroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 1
Names
Hin-2 protein
class E basic helix-loop-helix protein 74
renal carcinoma antigen NY-REN-52
steroid receptor coactivator-1
NP_003734.3
NP_671756.1
NP_671766.1
XP_005264682.1
XP_005264683.1
XP_016860657.1
XP_016860658.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029014.2 RefSeqGene

    Range
    4205..283653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001362950.1NP_001349879.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. NM_001362952.1NP_001349881.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1713.1
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  3. NM_001362954.1NP_001349883.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1713.1
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  4. NM_001362955.1NP_001349884.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  5. NM_003743.5NP_003734.3  nuclear receptor coactivator 1 isoform 1

    See identical proteins and their annotated locations for NP_003734.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as SRC1a, encodes the longest isoform (1).
    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1712.1
    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000320940.5, ENST00000348332.7
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  6. NM_147223.3NP_671756.1  nuclear receptor coactivator 1 isoform 2

    See identical proteins and their annotated locations for NP_671756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as SRC1e, contains an additional segment in the coding region compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1713.1
    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000288599.5, ENST00000288599.9
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  7. NM_147233.2NP_671766.1  nuclear receptor coactivator 1 isoform 3

    See identical proteins and their annotated locations for NP_671766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as SRC(-Q), uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 3) that lacks a single amino acid, compared to isoform 1.
    Source sequence(s)
    AC013459, AJ000881, BE675986, BF975824, CB047008, U90661
    Consensus CDS
    CCDS42660.1
    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000379197.3, ENST00000395856.3
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    24492050..24770702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005168.1XP_016860657.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000385097.1, ENST00000405141.5
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. XM_005264625.1XP_005264682.1  nuclear receptor coactivator 1 isoform X1

    See identical proteins and their annotated locations for XP_005264682.1

    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000385216.1, ENST00000406961.5
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  3. XM_017005169.2XP_016860658.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000385195.1, ENST00000407230.5
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  4. XM_005264626.1XP_005264683.1  nuclear receptor coactivator 1 isoform X2

    See identical proteins and their annotated locations for XP_005264683.1

    UniProtKB/Swiss-Prot
    Q15788
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
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