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NCOA1 nuclear receptor coactivator 1 [ Homo sapiens (human) ]

Gene ID: 8648, updated on 1-Jun-2020

Summary

Official Symbol
NCOA1provided by HGNC
Official Full Name
nuclear receptor coactivator 1provided by HGNC
Primary source
HGNC:HGNC:7668
See related
Ensembl:ENSG00000084676 MIM:602691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74
Summary
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 17.5), testis (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See NCOA1 in Genome Data Viewer
Location:
2p23.3
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (24491254..24770702)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24714919..24993571)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374329 Neighboring gene CRISPRi-validated cis-regulatory element chr2.904 Neighboring gene Sharpr-MPRA regulatory region 4589 Neighboring gene RNA, 5S ribosomal pseudogene 88 Neighboring gene RNA, U6 small nuclear 936, pseudogene Neighboring gene uncharacterized LOC105369164 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene centromere protein O Neighboring gene adenylate cyclase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
tat HIV-1 Tat-induced calcium mobilization and TNF-alpha production in primary human monocytes are entirely regulated by DHP receptors PubMed
tat SRC1a binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
Vpr vpr HIV-1 Vpr synergistically enhances SRC-1 ligand activated glucocorticoid receptor activity, however Vpr does not bind to SRC-1 PubMed
matrix gag HIV-1 MA upregulates NCOA1 gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129719, MGC129720

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
progesterone receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
retinoid X receptor binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
cellular response to Thyroglobulin triiodothyronine IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
histone H4 acetylation IEA
Inferred from Electronic Annotation
more info
 
hypothalamus development IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male mating behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter by galactose IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of thyroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 1
Names
Hin-2 protein
class E basic helix-loop-helix protein 74
renal carcinoma antigen NY-REN-52
steroid receptor coactivator-1
NP_001349879.1
NP_001349881.1
NP_001349883.1
NP_001349884.1
NP_003734.3
NP_671756.1
NP_671766.1
XP_005264682.1
XP_005264683.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029014.2 RefSeqGene

    Range
    4205..283653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001362950.1NP_001349879.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. NM_001362952.1NP_001349881.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1713.1
    Related
    ENSP00000385097.1, ENST00000405141.5
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  3. NM_001362954.1NP_001349883.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1713.1
    Related
    ENSP00000385195.1, ENST00000407230.5
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  4. NM_001362955.1NP_001349884.1  nuclear receptor coactivator 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013459, AC093798
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  5. NM_003743.5NP_003734.3  nuclear receptor coactivator 1 isoform 1

    See identical proteins and their annotated locations for NP_003734.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as SRC1a, encodes the longest isoform (1).
    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1712.1
    UniProtKB/Swiss-Prot
    Q15788
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  6. NM_147223.3NP_671756.1  nuclear receptor coactivator 1 isoform 2

    See identical proteins and their annotated locations for NP_671756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as SRC1e, contains an additional segment in the coding region compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC013459, AC093798
    Consensus CDS
    CCDS1713.1
    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000288599.5, ENST00000288599.9
    Conserved Domains (9) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:11491205
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:9741309
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  7. NM_147233.2NP_671766.1  nuclear receptor coactivator 1 isoform 3

    See identical proteins and their annotated locations for NP_671766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as SRC(-Q), uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 3) that lacks a single amino acid, compared to isoform 1.
    Source sequence(s)
    AC013459, AJ000881, BE675986, BF975824, CB047008, U90661
    Consensus CDS
    CCDS42660.1
    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000379197.3, ENST00000395856.3
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    24491254..24770702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264625.1XP_005264682.1  nuclear receptor coactivator 1 isoform X1

    See identical proteins and their annotated locations for XP_005264682.1

    UniProtKB/Swiss-Prot
    Q15788
    Related
    ENSP00000385216.1, ENST00000406961.5
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. XM_005264626.1XP_005264683.1  nuclear receptor coactivator 1 isoform X2

    See identical proteins and their annotated locations for XP_005264683.1

    UniProtKB/Swiss-Prot
    Q15788
    Conserved Domains (10) summary
    smart00353
    Location:3286
    HLH; helix loop helix domain
    cd00130
    Location:120213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam09606
    Location:9611359
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam00989
    Location:116173
    PAS; PAS fold
    pfam07469
    Location:12121268
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:924970
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:632708
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:260370
    PAS_11; PAS domain
    pfam16279
    Location:741818
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:468590
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
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