U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

STC2 stanniocalcin 2 [ Homo sapiens (human) ]

Gene ID: 8614, updated on 25-Sep-2022

Summary

Official Symbol
STC2provided by HGNC
Official Full Name
stanniocalcin 2provided by HGNC
Primary source
HGNC:HGNC:11374
See related
Ensembl:ENSG00000113739 MIM:603665; AllianceGenome:HGNC:11374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STC-2; STCRP
Summary
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 12.8), thyroid (RPKM 5.0) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See STC2 in Genome Data Viewer
Location:
5q35.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (173314723..173328414, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (173854781..173868472, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172741726..172755417, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377731 Neighboring gene uncharacterized LOC124901136 Neighboring gene microRNA 12118 Neighboring gene uncharacterized LOC124901137 Neighboring gene microRNA 8056

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in decidualization IEA
Inferred from Electronic Annotation
more info
 
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hormone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of store-operated calcium entry IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
stanniocalcin-2
Names
STC-related protein
stanniocalcin-related protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003714.3NP_003705.1  stanniocalcin-2 precursor

    See identical proteins and their annotated locations for NP_003705.1

    Status: REVIEWED

    Source sequence(s)
    AC106731, AK027663, AK095891, BQ181336
    Consensus CDS
    CCDS4388.1
    UniProtKB/Swiss-Prot
    O76061
    UniProtKB/TrEMBL
    Q6FHC9
    Related
    ENSP00000265087.4, ENST00000265087.9
    Conserved Domains (1) summary
    pfam03298
    Location:12214
    Stanniocalcin; Stanniocalcin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    173314723..173328414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    173854781..173868472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)