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Stc2 stanniocalcin 2 [ Mus musculus (house mouse) ]

Gene ID: 20856, updated on 5-Mar-2024

Summary

Official Symbol
Stc2provided by MGI
Official Full Name
stanniocalcin 2provided by MGI
Primary source
MGI:MGI:1316731
See related
Ensembl:ENSMUSG00000020303 AllianceGenome:MGI:1316731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stc-2; Stc2l; mustc2
Summary
Predicted to enable enzyme binding activity; heme binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including cellular calcium ion homeostasis; endoplasmic reticulum unfolded protein response; and regulation of store-operated calcium entry. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; olfactory epithelium; and vertebral axis musculature. Orthologous to human STC2 (stanniocalcin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 22.9), bladder adult (RPKM 16.4) and 14 other tissues See more
Orthologs
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Genomic context

See Stc2 in Genome Data Viewer
Location:
11 A4; 11 18.4 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (31309441..31320061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (31359441..31370061, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene STARR-seq mESC enhancer starr_29073 Neighboring gene GPN-loop GTPase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29074 Neighboring gene STARR-seq mESC enhancer starr_29075 Neighboring gene STARR-seq mESC enhancer starr_29076 Neighboring gene predicted gene, 40822 Neighboring gene STARR-seq mESC enhancer starr_29080 Neighboring gene predicted gene, 35012 Neighboring gene predicted gene, 39672 Neighboring gene predicted gene, 35063

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011491.3NP_035621.1  stanniocalcin-2 precursor

    See identical proteins and their annotated locations for NP_035621.1

    Status: VALIDATED

    Source sequence(s)
    AF031035
    Consensus CDS
    CCDS24512.1
    UniProtKB/Swiss-Prot
    O88452
    UniProtKB/TrEMBL
    Q5SS12, Q9DCS6
    Related
    ENSMUSP00000020546.3, ENSMUST00000020546.3
    Conserved Domains (1) summary
    pfam03298
    Location:12213
    Stanniocalcin; Stanniocalcin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    31309441..31320061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)