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PLPP1 phospholipid phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 8611, updated on 1-Jun-2020

Summary

Official Symbol
PLPP1provided by HGNC
Official Full Name
phospholipid phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:9228
See related
Ensembl:ENSG00000067113 MIM:607124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPP1; PAP2; LLP1a; PAP-2a; PPAP2A
Summary
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Expression
Broad expression in prostate (RPKM 96.2), gall bladder (RPKM 74.3) and 22 other tissues See more
Orthologs

Genomic context

See PLPP1 in Genome Data Viewer
Location:
5q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55424842..55535078, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54720670..54830906, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Mtr4 exosome RNA helicase Neighboring gene protein serine kinase H1 pseudogene Neighboring gene uncharacterized LOC107986415 Neighboring gene microRNA 5687 Neighboring gene ring finger protein 138 pseudogene 1 Neighboring gene adenylate kinase 4 pseudogene 2 Neighboring gene uncharacterized LOC105378975

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
diacylglycerol diphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidate phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
sphingosine-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
sphingosine-1-phosphate phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
intracellular steroid hormone receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
sphingosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phospholipid phosphatase 1
Names
lipid phosphate phosphohydrolase 1a
phosphatidate phosphohydrolase type 2a
phosphatidic acid phosphatase 2a
phosphatidic acid phosphatase type 2A
phosphatidic acid phosphohydrolase type 2a
type-2 phosphatidic acid phosphatase alpha
NP_003702.2
NP_795714.1
XP_006714787.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003711.4NP_003702.2  phospholipid phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_003702.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also named PAP2-a1) lacks an alternate exon and contains an in-frame alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct internal segment and is shorter, compared to isoform 2.
    Source sequence(s)
    AF014402, BC008787, BC039847, BC143281
    Consensus CDS
    CCDS34159.1
    UniProtKB/Swiss-Prot
    O14494
    UniProtKB/TrEMBL
    A0A024QZS3
    Related
    ENSP00000302229.8, ENST00000307259.9
    Conserved Domains (1) summary
    cd03384
    Location:98243
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_176895.2NP_795714.1  phospholipid phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_795714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also named PAP2-a2) encodes the longer isoform (2).
    Source sequence(s)
    AF014403, BC008787, BC039847, BC168254, BQ019387, CN338068, HY063640
    Consensus CDS
    CCDS34160.1
    UniProtKB/Swiss-Prot
    O14494
    UniProtKB/TrEMBL
    A0A024QZU7
    Related
    ENSP00000264775.5, ENST00000264775.9
    Conserved Domains (1) summary
    cd03384
    Location:99244
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RNA

  1. NR_103485.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF014402, BC008787, BC039847, BC168254, BQ019387, CN338068, HY063640

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55424842..55535078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714724.3XP_006714787.1  phospholipid phosphatase 1 isoform X1

    Conserved Domains (1) summary
    cd03384
    Location:35180
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
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