U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plpp1 phospholipid phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 19012, updated on 8-Feb-2024

Summary

Official Symbol
Plpp1provided by MGI
Official Full Name
phospholipid phosphatase 1provided by MGI
Primary source
MGI:MGI:108412
See related
Ensembl:ENSMUSG00000021759 AllianceGenome:MGI:108412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LPP1; mPAP; Hic53; LPP-1; PAP2a; Hpic53; PAP-2a; Ppap2a; PAP2-alpha
Summary
Enables diacylglycerol diphosphate phosphatase activity; lipid phosphatase activity; and phosphatidate phosphatase activity. Involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and sphingolipid metabolic process. Located in caveola. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human PLPP1 (phospholipid phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 77.1), lung adult (RPKM 58.1) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Plpp1 in Genome Data Viewer
Location:
13 D2.2; 13 63.93 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112937311..113004428)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112800777..112867894)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 9 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene STARR-seq mESC enhancer starr_35698 Neighboring gene STARR-seq mESC enhancer starr_35701 Neighboring gene predicted gene, 41067 Neighboring gene STARR-seq mESC enhancer starr_35702 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene STARR-positive B cell enhancer ABC_E7290 Neighboring gene STARR-positive B cell enhancer ABC_E1469 Neighboring gene DExH-box helicase 29 Neighboring gene 40S ribosomal protein S13-like Neighboring gene cyclin O

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables diacylglycerol diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diacylglycerol diphosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables diacylglycerol diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables phosphatidate phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables sphingosine-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphingosine-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ceramide metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within diacylglycerol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in sphingosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sphingosine metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
phospholipid phosphatase 1
Names
35 kDa PAP
hydrogen peroxide inducible protein 53
lipid phosphate phosphohydrolase 1
phosphatidate phosphohydrolase type 2a
phosphatidic acid phosphatase 2a
phosphatidic acid phosphatase type 2A
NP_032273.1
NP_032929.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008247.3NP_032273.1  phospholipid phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_032273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB851583, BC061161, CD742481
    Consensus CDS
    CCDS26776.1
    UniProtKB/Swiss-Prot
    Q61469
    Related
    ENSMUSP00000016144.5, ENSMUST00000016144.12
    Conserved Domains (1) summary
    cd03384
    Location:99244
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_008903.2NP_032929.1  phospholipid phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_032929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks one exon and contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BB851583, BY094239, CD742481, D84376
    Consensus CDS
    CCDS26777.1
    UniProtKB/Swiss-Prot
    Q61469, Q61690, Q6GT30, Q8BPB8
    Related
    ENSMUSP00000064423.7, ENSMUST00000070951.8
    Conserved Domains (1) summary
    cd03384
    Location:98243
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    112937311..113004428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)