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KHSRP KH-type splicing regulatory protein [ Homo sapiens (human) ]

Gene ID: 8570, updated on 12-Oct-2019

Summary

Official Symbol
KHSRPprovided by HGNC
Official Full Name
KH-type splicing regulatory proteinprovided by HGNC
Primary source
HGNC:HGNC:6316
See related
Ensembl:ENSG00000088247 MIM:603445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p75; FBP2; KSRP; FUBP2
Summary
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 37.2), endometrium (RPKM 25.1) and 25 other tissues See more
Orthologs

Genomic context

See KHSRP in Genome Data Viewer
Location:
19p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6413102..6424811, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6413115..6424822, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 1 Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene microRNA 6790 Neighboring gene microRNA 3940 Neighboring gene solute carrier family 25 member 41 Neighboring gene solute carrier family 25 member 23 Neighboring gene DENN domain containing 1C Neighboring gene crumbs cell polarity complex component 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of KH-type splicing regulatory protein (KHSRP, FUBP2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ATF4 activates genes, organism-specific biosystem (from REACTOME)
    ATF4 activates genes, organism-specific biosystemATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • KSRP (KHSRP) binds and destabilizes mRNA, organism-specific biosystem (from REACTOME)
    KSRP (KHSRP) binds and destabilizes mRNA, organism-specific biosystemKSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. The activity of KSR...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • PERK regulates gene expression, organism-specific biosystem (from REACTOME)
    PERK regulates gene expression, organism-specific biosystemPERK (EIF2AK3) is a single-pass transmembrane protein located in the endoplasmic reticulum (ER) membrane such that the N-terminus of PERK is luminal and the C-terminus is cytosolic. PERK is maintaine...
  • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
    Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...
  • Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystem (from REACTOME)
    Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99676

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
RNA splicing, via transesterification reactions TAS
Traceable Author Statement
more info
PubMed 
cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of low-density lipoprotein particle clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
far upstream element-binding protein 2
Names
FUSE-binding protein 2
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366299.1NP_001353228.1  far upstream element-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC011491, AC011539
    Conserved Domains (3) summary
    cd00105
    Location:146208
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam09005
    Location:671685
    DUF1897; Domain of unknown function (DUF1897)
    pfam00013
    Location:427493
    KH_1; KH domain
  2. NM_001366300.1NP_001353229.1  far upstream element-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC011491, AC011539
    Conserved Domains (2) summary
    pfam00013
    Location:146210
    KH_1; KH domain
    pfam09005
    Location:646660
    DUF1897; Domain of unknown function (DUF1897)
  3. NM_003685.3NP_003676.2  far upstream element-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_003676.2

    Status: VALIDATED

    Source sequence(s)
    AA976482, AC011491, BC085004, BQ186683, CB216491, CF123311, DC388502, U94832
    Consensus CDS
    CCDS45936.1
    UniProtKB/Swiss-Prot
    Q92945
    Related
    ENSP00000381216.2, ENST00000398148.7
    Conserved Domains (2) summary
    pfam00013
    Location:146210
    KH_1; KH domain
    pfam09005
    Location:671685
    DUF1897; Domain of unknown function (DUF1897)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6413102..6424811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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