Format

Send to:

Choose Destination

KHSRP KH-type splicing regulatory protein [ Homo sapiens (human) ]

Gene ID: 8570, updated on 5-Sep-2021

Summary

Official Symbol
KHSRPprovided by HGNC
Official Full Name
KH-type splicing regulatory proteinprovided by HGNC
Primary source
HGNC:HGNC:6316
See related
Ensembl:ENSG00000088247 MIM:603445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p75; FBP2; KSRP; FUBP2
Summary
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 37.2), endometrium (RPKM 25.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KHSRP in Genome Data Viewer
Location:
19p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6413102..6424811, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6413113..6424822, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 1 Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene microRNA 6790 Neighboring gene microRNA 3940 Neighboring gene solute carrier family 25 member 41 Neighboring gene solute carrier family 25 member 23 Neighboring gene DENN domain containing 1C Neighboring gene crumbs cell polarity complex component 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of KH-type splicing regulatory protein (KHSRP, FUBP2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99676

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
far upstream element-binding protein 2
Names
FUSE-binding protein 2
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366299.1NP_001353228.1  far upstream element-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC011491, AC011539
    Related
    ENSP00000471146.2, ENST00000600480.2
    Conserved Domains (5) summary
    pfam09005
    Location:671685
    DUF1897; Domain of unknown function (DUF1897)
    cd22479
    Location:145215
    KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22482
    Location:233305
    KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22485
    Location:323390
    KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22488
    Location:426494
    KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
  2. NM_001366300.1NP_001353229.1  far upstream element-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC011491, AC011539
    Conserved Domains (5) summary
    pfam09005
    Location:646660
    DUF1897; Domain of unknown function (DUF1897)
    cd22479
    Location:145215
    KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22482
    Location:233305
    KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22485
    Location:323390
    KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22488
    Location:426494
    KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
  3. NM_003685.3NP_003676.2  far upstream element-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_003676.2

    Status: VALIDATED

    Source sequence(s)
    AA976482, AC011491, BC085004, BQ186683, CB216491, CF123311, DC388502, U94832
    Consensus CDS
    CCDS45936.1
    UniProtKB/Swiss-Prot
    Q92945
    Related
    ENSP00000381216.2, ENST00000398148.7
    Conserved Domains (5) summary
    pfam09005
    Location:671685
    DUF1897; Domain of unknown function (DUF1897)
    cd22479
    Location:145215
    KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22482
    Location:233305
    KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22485
    Location:323390
    KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22488
    Location:426494
    KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6413102..6424811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center