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PRE1 proteasome core particle subunit beta 4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856731, updated on 10-Mar-2023

Summary

Gene symbol
PRE1
Gene description
proteasome core particle subunit beta 4
Primary source
SGD:S000000814
Locus tag
YER012W
See related
AllianceGenome:SGD:S000000814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endopeptidase activator activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and nucleus. Part of proteasome core complex, beta-subunit complex. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PRE1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (177835..178431)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene GPI-anchored mannoprotein Neighboring gene tRNA-Glu Neighboring gene DEAH-box ATP-dependent RNA helicase PRP22 Neighboring gene oxygen-dependent protoporphyrinogen oxidase Neighboring gene Bud25p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PRE1 gene: The PRE1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables endopeptidase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
proteasome core particle subunit beta 4
NP_010928.1
  • Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    177835..178431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178903.1NP_010928.1  TPA: proteasome core particle subunit beta 4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010928.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLQ9, P22141
    UniProtKB/TrEMBL
    A0A0L8VRW5, A0A6A5Q0W2, B3LS24, B5VHE3, C7GKJ0, C8Z712, G2WCP3, H0GEZ9, N1PA82
    Conserved Domains (1) summary
    cd03758
    Location:1194
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...