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MADD MAP kinase activating death domain [ Homo sapiens (human) ]

Gene ID: 8567, updated on 7-Oct-2018

Summary

Official Symbol
MADDprovided by HGNC
Official Full Name
MAP kinase activating death domainprovided by HGNC
Primary source
HGNC:HGNC:6766
See related
Ensembl:ENSG00000110514 MIM:603584; Vega:OTTHUMG00000150350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DENN; IG20; RAB3GEP
Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 18.3) and 25 other tissues See more
Orthologs

Genomic context

See MADD in Genome Data Viewer
Location:
11p11.2
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (47269376..47330031)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47290927..47351582)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene damage specific DNA binding protein 2 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene uncharacterized LOC101928943 Neighboring gene myosin binding protein C, cardiac Neighboring gene Spi-1 proto-oncogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
NHGRI GWA Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
NHGRI GWA Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
    Caspase cascade in apoptosis, organism-specific biosystem
    Caspase cascade in apoptosis
  • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Ceramide signaling pathway, organism-specific biosystem
    Ceramide signaling pathway
  • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
    Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
  • Deregulation of Rab and Rab Effector Genes in Bladder Cancer, organism-specific biosystem (from WikiPathways)
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer, organism-specific biosystemExample of the Rab27 cluster. The Rab27 cluster is comprised of the two RAB27 isoforms (RAB27A and RAB27B), the GEF MADD, the GAP TBC1D10A and 12 effector proteins
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
    RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemHuman cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of d...
  • Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
    Regulation of TNFR1 signaling, organism-specific biosystemTumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
  • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TNF receptor signaling pathway, organism-specific biosystem
    TNF receptor signaling pathway
  • TNF signaling, organism-specific biosystem (from REACTOME)
    TNF signaling, organism-specific biosystemThe inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) is expressed in immune and nonimmune cell types including macrophages, T cells, mast cells, granulocytes, natural killer (NK) cells, ...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35600, FLJ36300, KIAA0358

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rab guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rab guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
death receptor binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
MAP kinase-activating death domain protein
Names
Rab3 GDP/GTP exchange factor
differentially expressed in normal and neoplastic cells
insulinoma glucagonoma clone 20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029462.1 RefSeqGene

    Range
    5273..65656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135943.1NP_001129415.1  MAP kinase-activating death domain protein isoform i

    See identical proteins and their annotated locations for NP_001129415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, and uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (i) is shorter than isoform d.
    Source sequence(s)
    AF440100, BC040484, DA759613, U77352
    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  2. NM_001135944.1NP_001129416.1  MAP kinase-activating death domain protein isoform j

    See identical proteins and their annotated locations for NP_001129416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (j) is shorter than isoform d.
    Source sequence(s)
    AF440103, AK292442, AU077339, U77352
    Consensus CDS
    CCDS44589.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000378753.3, OTTHUMP00000237191, ENST00000395344.7, OTTHUMT00000396842
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  3. NM_003682.3NP_003673.3  MAP kinase-activating death domain protein isoform d

    See identical proteins and their annotated locations for NP_003673.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AF440100, AU077339, U77352
    Consensus CDS
    CCDS7930.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000310933.4, OTTHUMP00000197136, ENST00000311027.9, OTTHUMT00000317746
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  4. NM_130470.2NP_569826.2  MAP kinase-activating death domain protein isoform a

    See identical proteins and their annotated locations for NP_569826.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a different exon 1 sequence and lacks exons 16, 21 and 26, as compared to transcript variant 4. The resulting isoform (a) is shorter than isoform d.
    Source sequence(s)
    AC018410, AF440101, AF440103, DA187733, U77352
    Consensus CDS
    CCDS7931.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    UniProtKB/TrEMBL
    A0A0A0MRB5
    Related
    ENSP00000343902.4, OTTHUMP00000197131, ENST00000342922.8, OTTHUMT00000317741
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  5. NM_130471.2NP_569827.2  MAP kinase-activating death domain protein isoform b

    See identical proteins and their annotated locations for NP_569827.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exons 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (b) is missing regions of 43 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AF440102, AU077339, U77352
    Consensus CDS
    CCDS44587.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000384204.3, OTTHUMP00000197137, ENST00000407859.7, OTTHUMT00000317747
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  6. NM_130472.2NP_569828.2  MAP kinase-activating death domain protein isoform c

    See identical proteins and their annotated locations for NP_569828.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exons 16, 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (c) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AF440103, AU077339, U77352
    Consensus CDS
    CCDS44588.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000385585.1, OTTHUMP00000197132, ENST00000402799.5, OTTHUMT00000317742
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  7. NM_130473.2NP_569829.2  MAP kinase-activating death domain protein isoform e

    See identical proteins and their annotated locations for NP_569829.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 21 and 26 as compared to transcript variant 4. The resulting isoform (e) is missing regions of 18 aa and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AF440101, AU077339, U77352
    Consensus CDS
    CCDS7932.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000304505.6, OTTHUMP00000197135, ENST00000349238.7, OTTHUMT00000317745
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  8. NM_130474.2NP_569830.2  MAP kinase-activating death domain protein isoform f

    See identical proteins and their annotated locations for NP_569830.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exons 16, 21, 26, 34, and part of exon 13 but maintains the same reading frame up through exon 33 as compared to transcript variant 4. The resulting isoform (f) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa and has a different carboxyl terminus as compared to isoform d.
    Source sequence(s)
    AF440434, AU077339, U77352
    Consensus CDS
    CCDS44590.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000384435.1, OTTHUMP00000197133, ENST00000406482.5, OTTHUMT00000317743
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  9. NM_130475.2NP_569831.1  MAP kinase-activating death domain protein isoform g

    See identical proteins and their annotated locations for NP_569831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has a different exon 1 sequence and lacks exon 34 as compared to transcript variant 4. The resulting isoform (g) is shorter and has a different carboxyl terminus as compared to the isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AB002356, AF440100, DA759613, U77352
    Consensus CDS
    CCDS41642.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000378745.3, OTTHUMP00000197134, ENST00000395336.7, OTTHUMT00000317744
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  10. NM_130476.2NP_569832.2  MAP kinase-activating death domain protein isoform h

    See identical proteins and their annotated locations for NP_569832.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has a different exon 1 sequence, lacks exons 16, 21 and 26, and uses an alternate in-frame splice site in exon 23, as compared to transcript variant 4. The resulting isoform (h) is shorter than isoform d.
    Source sequence(s)
    AF440100, DA759613, U44953, U77352
    Consensus CDS
    CCDS44586.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000384287.2, OTTHUMP00000238029, ENST00000402192.6, OTTHUMT00000398339
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    47269376..47330031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018485.2XP_016873974.1  MAP kinase-activating death domain protein isoform X16

  2. XM_017018489.1XP_016873978.1  MAP kinase-activating death domain protein isoform X20

  3. XM_017018506.1XP_016873995.1  MAP kinase-activating death domain protein isoform X34

  4. XM_024448754.1XP_024304522.1  MAP kinase-activating death domain protein isoform X30

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  5. XM_017018499.1XP_016873988.1  MAP kinase-activating death domain protein isoform X32

  6. XM_005253189.3XP_005253246.1  MAP kinase-activating death domain protein isoform X3

    See identical proteins and their annotated locations for XP_005253246.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  7. XM_005253196.3XP_005253253.1  MAP kinase-activating death domain protein isoform X7

    See identical proteins and their annotated locations for XP_005253253.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  8. XM_017018480.2XP_016873969.1  MAP kinase-activating death domain protein isoform X8

  9. XM_017018479.2XP_016873968.1  MAP kinase-activating death domain protein isoform X6

  10. XM_017018482.2XP_016873971.1  MAP kinase-activating death domain protein isoform X12

  11. XM_017018484.2XP_016873973.1  MAP kinase-activating death domain protein isoform X16

  12. XM_017018483.2XP_016873972.1  MAP kinase-activating death domain protein isoform X14

  13. XM_005253201.3XP_005253258.1  MAP kinase-activating death domain protein isoform X21

    See identical proteins and their annotated locations for XP_005253258.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  14. XM_017018486.2XP_016873975.1  MAP kinase-activating death domain protein isoform X17

  15. XM_005253200.2XP_005253257.1  MAP kinase-activating death domain protein isoform X19

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  16. XM_017018488.1XP_016873977.1  MAP kinase-activating death domain protein isoform X20

  17. XM_017018492.1XP_016873981.1  MAP kinase-activating death domain protein isoform X26

  18. XM_024448751.1XP_024304519.1  MAP kinase-activating death domain protein isoform X24

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  19. XM_017018500.1XP_016873989.1  MAP kinase-activating death domain protein isoform X33

  20. XM_017018498.1XP_016873987.1  MAP kinase-activating death domain protein isoform X32

  21. XM_005253205.2XP_005253262.1  MAP kinase-activating death domain protein isoform X36

    See identical proteins and their annotated locations for XP_005253262.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  22. XM_024448746.1XP_024304514.1  MAP kinase-activating death domain protein isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  23. XM_017018481.1XP_016873970.1  MAP kinase-activating death domain protein isoform X11

  24. XM_024448748.1XP_024304516.1  MAP kinase-activating death domain protein isoform X9

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  25. XM_024448749.1XP_024304517.1  MAP kinase-activating death domain protein isoform X10

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  26. XM_017018487.2XP_016873976.1  MAP kinase-activating death domain protein isoform X18

  27. XM_017018490.1XP_016873979.1  MAP kinase-activating death domain protein isoform X22

  28. XM_017018493.1XP_016873982.1  MAP kinase-activating death domain protein isoform X27

  29. XM_017018507.1XP_016873996.1  MAP kinase-activating death domain protein isoform X35

  30. XM_024448750.1XP_024304518.1  MAP kinase-activating death domain protein isoform X13

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  31. XM_005253203.3XP_005253260.1  MAP kinase-activating death domain protein isoform X28

    See identical proteins and their annotated locations for XP_005253260.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  32. XM_024448752.1XP_024304520.1  MAP kinase-activating death domain protein isoform X25

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  33. XM_024448753.1XP_024304521.1  MAP kinase-activating death domain protein isoform X30

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  34. XM_024448755.1XP_024304523.1  MAP kinase-activating death domain protein isoform X31

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  35. XM_017018505.2XP_016873994.1  MAP kinase-activating death domain protein isoform X34

  36. XM_024448745.1XP_024304513.1  MAP kinase-activating death domain protein isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  37. XM_017018478.2XP_016873967.1  MAP kinase-activating death domain protein isoform X5

  38. XM_005253199.3XP_005253256.1  MAP kinase-activating death domain protein isoform X15

    See identical proteins and their annotated locations for XP_005253256.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    UniProtKB/TrEMBL
    A0A0A0MRB5
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  39. XM_017018491.2XP_016873980.1  MAP kinase-activating death domain protein isoform X23

  40. XM_024448747.1XP_024304515.1  MAP kinase-activating death domain protein isoform X4

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  41. XM_005253204.3XP_005253261.1  MAP kinase-activating death domain protein isoform X29

    See identical proteins and their annotated locations for XP_005253261.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
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