Format

Send to:

Choose Destination

MADD MAP kinase activating death domain [ Homo sapiens (human) ]

Gene ID: 8567, updated on 1-Aug-2020

Summary

Official Symbol
MADDprovided by HGNC
Official Full Name
MAP kinase activating death domainprovided by HGNC
Primary source
HGNC:HGNC:6766
See related
Ensembl:ENSG00000110514 MIM:603584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DENN; IG20; RAB3GEP
Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 18.3) and 25 other tissues See more
Orthologs

Genomic context

See MADD in Genome Data Viewer
Location:
11p11.2
Exon count:
42
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (47269188..47330031)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47290927..47351582)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene damage specific DNA binding protein 2 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene MADD antisense RNA 1 Neighboring gene myosin binding protein C3 Neighboring gene Spi-1 proto-oncogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
NHGRI GWA Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
NHGRI GWA Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35600, FLJ36300, KIAA0358

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rab guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rab guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
death receptor binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
MAP kinase-activating death domain protein
Names
Rab3 GDP/GTP exchange factor
differentially expressed in normal and neoplastic cells
insulinoma glucagonoma clone 20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029462.1 RefSeqGene

    Range
    5273..65656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135943.2NP_001129415.1  MAP kinase-activating death domain protein isoform 9

    See identical proteins and their annotated locations for NP_001129415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, and uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (i) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  2. NM_001135944.2NP_001129416.1  MAP kinase-activating death domain protein isoform 10

    See identical proteins and their annotated locations for NP_001129416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (j) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44589.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000378753.3, ENST00000395344.7
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  3. NM_001376571.1NP_001363500.1  MAP kinase-activating death domain protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  4. NM_001376572.1NP_001363501.1  MAP kinase-activating death domain protein isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  5. NM_001376573.1NP_001363502.1  MAP kinase-activating death domain protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  6. NM_001376574.1NP_001363503.1  MAP kinase-activating death domain protein isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  7. NM_001376575.1NP_001363504.1  MAP kinase-activating death domain protein isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  8. NM_001376576.1NP_001363505.1  MAP kinase-activating death domain protein isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  9. NM_001376577.1NP_001363506.1  MAP kinase-activating death domain protein isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  10. NM_001376578.1NP_001363507.1  MAP kinase-activating death domain protein isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  11. NM_001376579.1NP_001363508.1  MAP kinase-activating death domain protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  12. NM_001376580.1NP_001363509.1  MAP kinase-activating death domain protein isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  13. NM_001376581.1NP_001363510.1  MAP kinase-activating death domain protein isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  14. NM_001376582.1NP_001363511.1  MAP kinase-activating death domain protein isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  15. NM_001376583.1NP_001363512.1  MAP kinase-activating death domain protein isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  16. NM_001376584.1NP_001363513.1  MAP kinase-activating death domain protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  17. NM_001376585.1NP_001363514.1  MAP kinase-activating death domain protein isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  18. NM_001376586.1NP_001363515.1  MAP kinase-activating death domain protein isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  19. NM_001376593.1NP_001363522.1  MAP kinase-activating death domain protein isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  20. NM_001376594.1NP_001363523.1  MAP kinase-activating death domain protein isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  21. NM_001376595.1NP_001363524.1  MAP kinase-activating death domain protein isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  22. NM_001376596.1NP_001363525.1  MAP kinase-activating death domain protein isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  23. NM_001376597.1NP_001363526.1  MAP kinase-activating death domain protein isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  24. NM_001376598.1NP_001363527.1  MAP kinase-activating death domain protein isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  25. NM_001376599.1NP_001363528.1  MAP kinase-activating death domain protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  26. NM_001376600.1NP_001363529.1  MAP kinase-activating death domain protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  27. NM_001376601.1NP_001363530.1  MAP kinase-activating death domain protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  28. NM_001376602.1NP_001363531.1  MAP kinase-activating death domain protein isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  29. NM_001376603.1NP_001363532.1  MAP kinase-activating death domain protein isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  30. NM_001376604.1NP_001363533.1  MAP kinase-activating death domain protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  31. NM_001376605.1NP_001363534.1  MAP kinase-activating death domain protein isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  32. NM_001376606.1NP_001363535.1  MAP kinase-activating death domain protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  33. NM_001376607.1NP_001363536.1  MAP kinase-activating death domain protein isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  34. NM_001376608.1NP_001363537.1  MAP kinase-activating death domain protein isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  35. NM_001376609.1NP_001363538.1  MAP kinase-activating death domain protein isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  36. NM_001376610.1NP_001363539.1  MAP kinase-activating death domain protein isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  37. NM_001376611.1NP_001363540.1  MAP kinase-activating death domain protein isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  38. NM_001376612.1NP_001363541.1  MAP kinase-activating death domain protein isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  39. NM_001376613.1NP_001363542.1  MAP kinase-activating death domain protein isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  40. NM_001376614.1NP_001363543.1  MAP kinase-activating death domain protein isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  41. NM_001376615.1NP_001363544.1  MAP kinase-activating death domain protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  42. NM_001376616.1NP_001363545.1  MAP kinase-activating death domain protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  43. NM_001376617.1NP_001363546.1  MAP kinase-activating death domain protein isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  44. NM_001376618.1NP_001363547.1  MAP kinase-activating death domain protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  45. NM_001376619.1NP_001363548.1  MAP kinase-activating death domain protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  46. NM_001376620.1NP_001363549.1  MAP kinase-activating death domain protein isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  47. NM_001376621.1NP_001363550.1  MAP kinase-activating death domain protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  48. NM_001376622.1NP_001363551.1  MAP kinase-activating death domain protein isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  49. NM_001376623.1NP_001363552.1  MAP kinase-activating death domain protein isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  50. NM_001376624.1NP_001363553.1  MAP kinase-activating death domain protein isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  51. NM_001376625.1NP_001363554.1  MAP kinase-activating death domain protein isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  52. NM_001376626.1NP_001363555.1  MAP kinase-activating death domain protein isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  53. NM_001376627.1NP_001363556.1  MAP kinase-activating death domain protein isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  54. NM_001376628.1NP_001363557.1  MAP kinase-activating death domain protein isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  55. NM_001376629.1NP_001363558.1  MAP kinase-activating death domain protein isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  56. NM_001376630.1NP_001363559.1  MAP kinase-activating death domain protein isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  57. NM_001376631.1NP_001363560.1  MAP kinase-activating death domain protein isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  58. NM_001376632.1NP_001363561.1  MAP kinase-activating death domain protein isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  59. NM_001376633.1NP_001363562.1  MAP kinase-activating death domain protein isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  60. NM_001376634.1NP_001363563.1  MAP kinase-activating death domain protein isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  61. NM_001376635.1NP_001363564.1  MAP kinase-activating death domain protein isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  62. NM_001376636.1NP_001363565.1  MAP kinase-activating death domain protein isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  63. NM_001376637.1NP_001363566.1  MAP kinase-activating death domain protein isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  64. NM_001376638.1NP_001363567.1  MAP kinase-activating death domain protein isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  65. NM_001376639.1NP_001363568.1  MAP kinase-activating death domain protein isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  66. NM_001376640.1NP_001363569.1  MAP kinase-activating death domain protein isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  67. NM_001376641.1NP_001363570.1  MAP kinase-activating death domain protein isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  68. NM_001376642.1NP_001363571.1  MAP kinase-activating death domain protein isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  69. NM_001376643.1NP_001363572.1  MAP kinase-activating death domain protein isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  70. NM_001376644.1NP_001363573.1  MAP kinase-activating death domain protein isoform 57

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  71. NM_001376645.1NP_001363574.1  MAP kinase-activating death domain protein isoform 58

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  72. NM_001376646.1NP_001363575.1  MAP kinase-activating death domain protein isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  73. NM_001376647.1NP_001363576.1  MAP kinase-activating death domain protein isoform 60

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  74. NM_001376648.1NP_001363577.1  MAP kinase-activating death domain protein isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  75. NM_001376649.1NP_001363578.1  MAP kinase-activating death domain protein isoform 62

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  76. NM_001376650.1NP_001363579.1  MAP kinase-activating death domain protein isoform 63

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  77. NM_001376651.1NP_001363580.1  MAP kinase-activating death domain protein isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  78. NM_001376652.1NP_001363581.1  MAP kinase-activating death domain protein isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  79. NM_001376653.1NP_001363582.1  MAP kinase-activating death domain protein isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  80. NM_001376654.1NP_001363583.1  MAP kinase-activating death domain protein isoform 66

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  81. NM_001376655.1NP_001363584.1  MAP kinase-activating death domain protein isoform 67

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  82. NM_001376656.1NP_001363585.1  MAP kinase-activating death domain protein isoform 67

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  83. NM_001376657.1NP_001363586.1  MAP kinase-activating death domain protein isoform 68

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  84. NM_001376658.1NP_001363587.1  MAP kinase-activating death domain protein isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  85. NM_001376659.1NP_001363588.1  MAP kinase-activating death domain protein isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  86. NM_001376660.1NP_001363589.1  MAP kinase-activating death domain protein isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  87. NM_001376661.1NP_001363590.1  MAP kinase-activating death domain protein isoform 72

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  88. NM_001376662.1NP_001363591.1  MAP kinase-activating death domain protein isoform 73

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  89. NM_001376663.1NP_001363592.1  MAP kinase-activating death domain protein isoform 74

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  90. NM_003682.4NP_003673.3  MAP kinase-activating death domain protein isoform 4

    See identical proteins and their annotated locations for NP_003673.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS7930.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000310933.4, ENST00000311027.9
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  91. NM_130470.3NP_569826.2  MAP kinase-activating death domain protein isoform 1

    See identical proteins and their annotated locations for NP_569826.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a different exon 1 sequence and lacks exons 16, 21 and 26, as compared to transcript variant 4. The resulting isoform (a) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS7931.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    UniProtKB/TrEMBL
    A0A0A0MRB5
    Related
    ENSP00000343902.4, ENST00000342922.8
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  92. NM_130471.3NP_569827.2  MAP kinase-activating death domain protein isoform 2

    See identical proteins and their annotated locations for NP_569827.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exons 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (b) is missing regions of 43 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44587.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000384204.3, ENST00000407859.7
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  93. NM_130472.3NP_569828.2  MAP kinase-activating death domain protein isoform 3

    See identical proteins and their annotated locations for NP_569828.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exons 16, 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (c) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44588.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000385585.1, ENST00000402799.5
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  94. NM_130473.3NP_569829.2  MAP kinase-activating death domain protein isoform 5

    See identical proteins and their annotated locations for NP_569829.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 21 and 26 as compared to transcript variant 4. The resulting isoform (e) is missing regions of 18 aa and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS7932.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000304505.6, ENST00000349238.7
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  95. NM_130474.3NP_569830.2  MAP kinase-activating death domain protein isoform 6

    See identical proteins and their annotated locations for NP_569830.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exons 16, 21, 26, 34, and part of exon 13 but maintains the same reading frame up through exon 33 as compared to transcript variant 4. The resulting isoform (f) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa and has a different carboxyl terminus as compared to isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44590.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000384435.1, ENST00000406482.5
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  96. NM_130475.3NP_569831.1  MAP kinase-activating death domain protein isoform 7

    See identical proteins and their annotated locations for NP_569831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has a different exon 1 sequence and lacks exon 34 as compared to transcript variant 4. The resulting isoform (g) is shorter and has a different carboxyl terminus as compared to the isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS41642.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000378745.3, ENST00000395336.7
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  97. NM_130476.3NP_569832.2  MAP kinase-activating death domain protein isoform 8

    See identical proteins and their annotated locations for NP_569832.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has a different exon 1 sequence, lacks exons 16, 21 and 26, and uses an alternate in-frame splice site in exon 23, as compared to transcript variant 4. The resulting isoform (h) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44586.1
    UniProtKB/Swiss-Prot
    Q8WXG6
    Related
    ENSP00000384287.2, ENST00000402192.6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RNA

  1. NR_164835.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  2. NR_164836.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  3. NR_164837.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  4. NR_164838.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  5. NR_164839.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  6. NR_164840.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  7. NR_164841.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
  8. NR_164842.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    47269188..47330031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253189.3XP_005253246.1  MAP kinase-activating death domain protein isoform X3

    See identical proteins and their annotated locations for XP_005253246.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  2. XM_005253196.3XP_005253253.1  MAP kinase-activating death domain protein isoform X7

    See identical proteins and their annotated locations for XP_005253253.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  3. XM_017018480.2XP_016873969.1  MAP kinase-activating death domain protein isoform X8

  4. XM_017018479.2XP_016873968.1  MAP kinase-activating death domain protein isoform X6

  5. XM_017018482.2XP_016873971.1  MAP kinase-activating death domain protein isoform X12

  6. XM_005253201.3XP_005253258.1  MAP kinase-activating death domain protein isoform X21

    See identical proteins and their annotated locations for XP_005253258.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  7. XM_017018486.2XP_016873975.1  MAP kinase-activating death domain protein isoform X17

  8. XM_005253200.2XP_005253257.1  MAP kinase-activating death domain protein isoform X19

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  9. XM_024448751.1XP_024304519.1  MAP kinase-activating death domain protein isoform X24

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  10. XM_017018500.1XP_016873989.1  MAP kinase-activating death domain protein isoform X33

  11. XM_005253205.2XP_005253262.1  MAP kinase-activating death domain protein isoform X36

    See identical proteins and their annotated locations for XP_005253262.1

    UniProtKB/Swiss-Prot
    Q8WXG6
    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  12. XM_024448746.1XP_024304514.1  MAP kinase-activating death domain protein isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  13. XM_024448748.1XP_024304516.1  MAP kinase-activating death domain protein isoform X9

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  14. XM_024448749.1XP_024304517.1  MAP kinase-activating death domain protein isoform X10

    Conserved Domains (3) summary
    smart00801
    Location:486554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:898
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
Support Center