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PIAS1 protein inhibitor of activated STAT 1 [ Homo sapiens (human) ]

Gene ID: 8554, updated on 24-Nov-2020

Summary

Official Symbol
PIAS1provided by HGNC
Official Full Name
protein inhibitor of activated STAT 1provided by HGNC
Primary source
HGNC:HGNC:2752
See related
Ensembl:ENSG00000033800 MIM:603566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP; ZMIZ3; DDXBP1; GU/RH-II
Summary
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in thyroid (RPKM 10.0), ovary (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See PIAS1 in Genome Data Viewer
Location:
15q23
Exon count:
20
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (68054315..68193847)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68346572..68483797)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr15.1880 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene uncharacterized LOC105370871 Neighboring gene Sharpr-MPRA regulatory region 569 Neighboring gene calmodulin like 4 Neighboring gene CLN6 transmembrane ER protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141878, MGC141879

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
protein-DNA complex assembly IEA
Inferred from Electronic Annotation
more info
 
receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
PubMed 
regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS1
Names
AR interacting protein
DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
DEAD/H box-binding protein 1
E3 SUMO-protein transferase PIAS1
RNA helicase II-binding protein
gu-binding protein
protein inhibitor of activated STAT protein 1
zinc finger, MIZ-type containing 3
NP_001307616.1
NP_057250.1
XP_011520428.1
XP_011520429.1
XP_016878177.1
XP_016878178.1
XP_016878179.1
XP_016878180.1
XP_024305862.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320687.1NP_001307616.1  E3 SUMO-protein ligase PIAS1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA837658, AC107871, AC135628, AK094641
    Consensus CDS
    CCDS81902.1
    UniProtKB/Swiss-Prot
    O75925
    Related
    ENSP00000438574.1, ENST00000545237.1
    Conserved Domains (3) summary
    smart00513
    Location:1347
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:333381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:137273
    PINIT; PINIT domain
  2. NM_016166.3NP_057250.1  E3 SUMO-protein ligase PIAS1 isoform 2

    See identical proteins and their annotated locations for NP_057250.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' structure which results in a distinct 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA837658, AC107871, AF167160
    Consensus CDS
    CCDS45290.1
    UniProtKB/Swiss-Prot
    O75925
    Related
    ENSP00000249636.6, ENST00000249636.10
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:332379
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:137280
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    68054315..68193847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450094.1XP_024305862.1  E3 SUMO-protein ligase PIAS1 isoform X6

    Conserved Domains (2) summary
    pfam14324
    Location:987
    PINIT; PINIT domain
    cd16790
    Location:148195
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  2. XM_011522126.2XP_011520428.1  E3 SUMO-protein ligase PIAS1 isoform X1

    Conserved Domains (3) summary
    smart00513
    Location:2054
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:340388
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:144280
    PINIT; PINIT domain
  3. XM_017022689.1XP_016878178.1  E3 SUMO-protein ligase PIAS1 isoform X4

  4. XM_011522127.2XP_011520429.1  E3 SUMO-protein ligase PIAS1 isoform X3

    Conserved Domains (3) summary
    smart00513
    Location:539
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:325373
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:129265
    PINIT; PINIT domain
  5. XM_017022688.1XP_016878177.1  E3 SUMO-protein ligase PIAS1 isoform X2

    UniProtKB/Swiss-Prot
    O75925
    Conserved Domains (3) summary
    smart00513
    Location:1347
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:333381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:137273
    PINIT; PINIT domain
  6. XM_017022690.1XP_016878179.1  E3 SUMO-protein ligase PIAS1 isoform X5

    UniProtKB/TrEMBL
    Q1XBU8
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:323370
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128271
    PINIT; PINIT domain
  7. XM_017022691.2XP_016878180.1  E3 SUMO-protein ligase PIAS1 isoform X5

    UniProtKB/TrEMBL
    Q1XBU8
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:323370
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128271
    PINIT; PINIT domain
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