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Pias1 protein inhibitor of activated STAT 1 [ Mus musculus (house mouse) ]

Gene ID: 56469, updated on 8-Feb-2024

Summary

Official Symbol
Pias1provided by MGI
Official Full Name
protein inhibitor of activated STAT 1provided by MGI
Primary source
MGI:MGI:1913125
See related
Ensembl:ENSMUSG00000032405 AllianceGenome:MGI:1913125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GBP; Ddxbp1; 2900068C24Rik
Summary
Enables SUMO transferase activity and ubiquitin protein ligase binding activity. Involved in several processes, including fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein sumoylation. Located in nucleus. Colocalizes with PML body. Is expressed in several structures, including branchial arch; genitourinary system; sensory organ; tooth; and trunk mesenchyme. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.8), lung adult (RPKM 10.1) and 28 other tissues See more
Orthologs
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Genomic context

See Pias1 in Genome Data Viewer
Location:
9 B; 9 33.91 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62785648..62888161, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62878366..62980879, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribsomal protein S2 pseudogene Neighboring gene ceroid-lipofuscinosis, neuronal 6 Neighboring gene calmodulin-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E10555 Neighboring gene STARR-positive B cell enhancer ABC_E6752 Neighboring gene STARR-positive B cell enhancer ABC_E9029 Neighboring gene STARR-positive B cell enhancer ABC_E9765 Neighboring gene STARR-positive B cell enhancer ABC_E9766 Neighboring gene predicted gene, 35574 Neighboring gene predicted gene, 24526 Neighboring gene predicted gene, 39354

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SUMO ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-DNA complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS1
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
DEAD/H box-binding protein 1
RING-type E3 ubiquitin transferase PIAS1
protein inhibitor of activated STAT protein 1
NP_062637.2
XP_006511365.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019663.3NP_062637.2  E3 SUMO-protein ligase PIAS1

    See identical proteins and their annotated locations for NP_062637.2

    Status: PROVISIONAL

    Source sequence(s)
    AK075708
    Consensus CDS
    CCDS40665.1
    UniProtKB/Swiss-Prot
    O88907, Q8C6H5
    UniProtKB/TrEMBL
    Q2M4G9, Q3U556
    Related
    ENSMUSP00000096248.5, ENSMUST00000098651.6
    Conserved Domains (4) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    COG5222
    Location:313428
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd16790
    Location:332379
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:137280
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    62785648..62888161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511302.4XP_006511365.1  E3 SUMO-protein ligase PIAS1 isoform X1

    UniProtKB/TrEMBL
    Q3U556
    Conserved Domains (4) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    COG5222
    Location:304419
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd16790
    Location:323370
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:128271
    PINIT; PINIT domain