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UNK unk zinc finger [ Homo sapiens (human) ]

Gene ID: 85451, updated on 5-Jul-2020

Summary

Official Symbol
UNKprovided by HGNC
Official Full Name
unk zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:29369
See related
Ensembl:ENSG00000132478 MIM:616375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H5; UNKEMPT; ZC3HDC5
Expression
Ubiquitous expression in ovary (RPKM 4.4), spleen (RPKM 4.1) and 25 other tissues See more
Orthologs

Genomic context

See UNK in Genome Data Viewer
Location:
17q25.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75784771..75825799)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73780920..73821886)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3.3 histone B Neighboring gene microRNA 4738 Neighboring gene Sharpr-MPRA regulatory region 1193 Neighboring gene unc-13 homolog D Neighboring gene WW domain binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA CDS binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA CDS binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polysome binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell morphogenesis involved in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
polysome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RING finger protein unkempt homolog
Names
unk family zinc finger
unkempt family zinc finger
unkempt homolog
zinc finger CCCH domain-containing protein 5
zinc finger CCCH-type containing 5
zinc finger CCCH-type domain containing 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080419.3NP_001073888.2  RING finger protein unkempt homolog

    See identical proteins and their annotated locations for NP_001073888.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC087289, AK307289, BC053362
    Consensus CDS
    CCDS45778.2
    UniProtKB/Swiss-Prot
    Q9C0B0
    UniProtKB/TrEMBL
    A0A024R8N4
    Related
    ENSP00000464893.1, ENST00000589666.6
    Conserved Domains (3) summary
    pfam00642
    Location:294320
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd16614
    Location:768801
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    cl26472
    Location:653758
    DUF3084; Protein of unknown function (DUF3084)

RNA

  1. NR_038131.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087289, BC064927
    Related
    ENST00000586527.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75784771..75825799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025248.1XP_016880737.1  RING finger protein unkempt homolog isoform X1

    Conserved Domains (4) summary
    COG5063
    Location:153347
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    pfam00642
    Location:323349
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:794830
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21478
    Location:659757
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. XM_017025250.1XP_016880739.1  RING finger protein unkempt homolog isoform X4

    Conserved Domains (4) summary
    smart00356
    Location:4771
    ZnF_C3H1; zinc finger
    pfam00642
    Location:126152
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:478554
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:597633
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. XM_017025247.1XP_016880736.1  RING finger protein unkempt homolog isoform X1

    Conserved Domains (4) summary
    COG5063
    Location:153347
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    pfam00642
    Location:323349
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:794830
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21478
    Location:659757
    ATP-synt_B; ATP synthase B/B' CF(0)
  4. XM_006722145.3XP_006722208.1  RING finger protein unkempt homolog isoform X2

    Conserved Domains (4) summary
    COG5063
    Location:153347
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    pfam00642
    Location:323349
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:782818
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21478
    Location:647745
    ATP-synt_B; ATP synthase B/B' CF(0)
  5. XM_017025249.1XP_016880738.1  RING finger protein unkempt homolog isoform X3

  6. XM_006722148.2XP_006722211.1  RING finger protein unkempt homolog isoform X4

    See identical proteins and their annotated locations for XP_006722211.1

    Conserved Domains (4) summary
    smart00356
    Location:4771
    ZnF_C3H1; zinc finger
    pfam00642
    Location:126152
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:478554
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:597633
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  7. XM_011525400.1XP_011523702.1  RING finger protein unkempt homolog isoform X4

    See identical proteins and their annotated locations for XP_011523702.1

    Conserved Domains (4) summary
    smart00356
    Location:4771
    ZnF_C3H1; zinc finger
    pfam00642
    Location:126152
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:478554
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:597633
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  8. XM_011525401.2XP_011523703.1  RING finger protein unkempt homolog isoform X5

    Conserved Domains (3) summary
    pfam00642
    Location:430
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:356432
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:475511
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
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