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UNK unk zinc finger [ Homo sapiens (human) ]

Gene ID: 85451, updated on 25-Nov-2025
Official Symbol
UNKprovided by HGNC
Official Full Name
unk zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:29369
See related
Ensembl:ENSG00000132478 MIM:616375; AllianceGenome:HGNC:29369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H5; UNKEMPT; ZC3HDC5
Summary
Enables mRNA CDS binding activity. Involved in cell morphogenesis involved in neuron differentiation and negative regulation of cytoplasmic translation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in ovary (RPKM 4.4), spleen (RPKM 4.1) and 25 other tissues See more
Orthologs
mouse all
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See UNK in Genome Data Viewer
Location:
17q25.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75784806..75825799)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76678053..76718950)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73780887..73821880)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12776 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73774948-73775552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12777 Neighboring gene H3.3 histone B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73780981-73781559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73781560-73782137 Neighboring gene microRNA 4738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73810697-73811198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73811199-73811698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73812483-73812984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73812985-73813484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73825830-73826818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73826819-73827806 Neighboring gene unc-13 homolog D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73831316-73831816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73832318-73833318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73834667-73835166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73840002-73840706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12780 Neighboring gene WW domain binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8989 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73852240-73853035

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Murn J, et al. Nat Struct Mol Biol, 2016 Jan. PMID 26641712, Free PMC Article
  2. Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling. Zuo Y, et al. Nat Commun, 2020 Mar 2. PMID 32123171, Free PMC Article
  3. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article
  4. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. Tao WA, et al. Nat Methods, 2005 Aug. PMID 16094384
  5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Dec 31. PMID 11214970

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA CDS binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA CDS binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA CDS binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell morphogenesis involved in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
Preferred Names
RING finger protein unkempt homolog
Names
unk family zinc finger
unkempt family zinc finger
unkempt homolog
zinc finger CCCH domain-containing protein 5
zinc finger CCCH-type containing 5
zinc finger CCCH-type domain containing 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080419.3 → NP_001073888.2  RING finger protein unkempt homolog

    See identical proteins and their annotated locations for NP_001073888.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC087289, AK307289, BC053362
    Consensus CDS
    CCDS45778.2
    UniProtKB/Swiss-Prot
    Q9C0B0
    Related
    ENSP00000464893.1, ENST00000589666.6
    Conserved Domains (5) summary
    COG4372
    Location:653 → 758
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    COG5063
    Location:124 → 318
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    cd16614
    Location:768 → 801
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:294 → 319
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18384
    Location:34 → 69
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

RNA

  1. NR_038131.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087289, BC064927
    Related
    ENST00000586527.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75784806..75825799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436965.1 → XP_047292921.1  RING finger protein unkempt homolog isoform X4

  2. XM_011525400.2 → XP_011523702.1  RING finger protein unkempt homolog isoform X5

    See identical proteins and their annotated locations for XP_011523702.1

    Conserved Domains (4) summary
    smart00356
    Location:47 → 71
    ZnF_C3H1; zinc finger
    pfam00642
    Location:126 → 152
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:478 → 554
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:597 → 633
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. XM_047436964.1 → XP_047292920.1  RING finger protein unkempt homolog isoform X3

    Related
    ENSP00000595728.1, ENST00000925669.1

  4. XM_047436962.1 → XP_047292918.1  RING finger protein unkempt homolog isoform X1

  5. XM_017025248.2 → XP_016880737.1  RING finger protein unkempt homolog isoform X1

    Conserved Domains (4) summary
    COG5063
    Location:153 → 347
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    pfam00642
    Location:323 → 349
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13920
    Location:794 → 830
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21478
    Location:659 → 757
    ATP-synt_B; ATP synthase B/B' CF(0)

  6. XM_017025249.2 → XP_016880738.1  RING finger protein unkempt homolog isoform X4

  7. XM_047436963.1 → XP_047292919.1  RING finger protein unkempt homolog isoform X2

  8. XM_047436966.1 → XP_047292922.1  RING finger protein unkempt homolog isoform X5

  9. XM_006722148.3 → XP_006722211.1  RING finger protein unkempt homolog isoform X5

    See identical proteins and their annotated locations for XP_006722211.1

    Conserved Domains (4) summary
    smart00356
    Location:47 → 71
    ZnF_C3H1; zinc finger
    pfam00642
    Location:126 → 152
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:478 → 554
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:597 → 633
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  10. XM_011525401.3 → XP_011523703.1  RING finger protein unkempt homolog isoform X6

    Conserved Domains (3) summary
    pfam00642
    Location:4 → 30
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:356 → 432
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:475 → 511
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76678053..76718950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317617.1 → XP_054173592.1  RING finger protein unkempt homolog isoform X5

  2. XM_054317613.1 → XP_054173588.1  RING finger protein unkempt homolog isoform X3

  3. XM_054317615.1 → XP_054173590.1  RING finger protein unkempt homolog isoform X4

  4. XM_054317611.1 → XP_054173586.1  RING finger protein unkempt homolog isoform X1

  5. XM_054317614.1 → XP_054173589.1  RING finger protein unkempt homolog isoform X4

  6. XM_054317612.1 → XP_054173587.1  RING finger protein unkempt homolog isoform X2

  7. XM_054317616.1 → XP_054173591.1  RING finger protein unkempt homolog isoform X5

  8. XM_054317618.1 → XP_054173593.1  RING finger protein unkempt homolog isoform X5

  9. XM_054317619.1 → XP_054173594.1  RING finger protein unkempt homolog isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0B0.2 GenPept UniProtKB/Swiss-Prot:Q9C0B0

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