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Unk unkempt family zinc finger [ Mus musculus (house mouse) ]

Gene ID: 217331, updated on 30-Apr-2024

Summary

Official Symbol
Unkprovided by MGI
Official Full Name
unkempt family zinc fingerprovided by MGI
Primary source
MGI:MGI:2442456
See related
Ensembl:ENSMUSG00000020770 AllianceGenome:MGI:2442456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unkh; Zc3h5; Zc3hdc5; mKIAA1753; B230379M23Rik
Summary
Enables mRNA CDS binding activity and polysome binding activity. Acts upstream of or within cell morphogenesis involved in neuron differentiation; in utero embryonic development; and neuron migration. Predicted to be located in cytoplasm. Predicted to be part of polysome. Is expressed in central nervous system; early conceptus; future brain; oocyte; and retina nuclear layer. Orthologous to human UNK (unk zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 15.6), limb E14.5 (RPKM 14.9) and 28 other tissues See more
Orthologs
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Genomic context

See Unk in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115921117..115952040)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116028616..116061214)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene integrin beta 4 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene galactokinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene STARR-seq mESC enhancer starr_31192 Neighboring gene predicted gene, 38482 Neighboring gene unc-13 homolog D Neighboring gene STARR-positive B cell enhancer ABC_E10732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115939592-115939779 Neighboring gene STARR-positive B cell enhancer ABC_E381 Neighboring gene WW domain binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA CDS binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA CDS binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RING finger protein unkempt homolog
Names
unkempt homolog
zinc finger CCCH domain-containing protein 5
zinc finger CCCH type containing 5
zinc finger CCCH type domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286006.1NP_001272935.1  RING finger protein unkempt homolog isoform 2

    See identical proteins and their annotated locations for NP_001272935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK134361, BB619163, BC033048
    Consensus CDS
    CCDS70351.1
    UniProtKB/TrEMBL
    Q3UYU7
    Related
    ENSMUSP00000102060.2, ENSMUST00000106452.2
    Conserved Domains (3) summary
    pfam00642
    Location:294318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam05384
    Location:633706
    DegS; Sensor protein DegS
    pfam13920
    Location:752788
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_172569.4NP_766157.1  RING finger protein unkempt homolog isoform 1

    See identical proteins and their annotated locations for NP_766157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK046395, BB619163, BC033048
    Consensus CDS
    CCDS25655.1
    UniProtKB/Swiss-Prot
    A2A853, Q8BL48, Q8BVI6, Q99JZ8, Q99LL9
    Related
    ENSMUSP00000021116.6, ENSMUST00000021116.12
    Conserved Domains (3) summary
    pfam00642
    Location:294318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam05384
    Location:646719
    DegS; Sensor protein DegS
    pfam13920
    Location:765801
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115921117..115952040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533088.5XP_006533151.1  RING finger protein unkempt homolog isoform X1

    Conserved Domains (6) summary
    PHA03307
    Location:300571
    PHA03307; transcriptional regulator ICP4; Provisional
    COG4372
    Location:625730
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    TIGR02680
    Location:485733
    TIGR02680; TIGR02680 family protein
    cd16614
    Location:740773
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:294318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18384
    Location:3469
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
  2. XM_030245897.2XP_030101757.1  RING finger protein unkempt homolog isoform X3

    Conserved Domains (5) summary
    smart00356
    Location:4771
    ZnF_C3H1; zinc finger
    COG4372
    Location:457562
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    TIGR02680
    Location:317565
    TIGR02680; TIGR02680 family protein
    cd16614
    Location:572605
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:126150
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  3. XM_006533089.4XP_006533152.1  RING finger protein unkempt homolog isoform X2

    Related
    ENSMUST00000150759.8
    Conserved Domains (4) summary
    smart00356
    Location:4771
    ZnF_C3H1; zinc finger
    PRK11448
    Location:452583
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:600633
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:126150
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  4. XM_036156606.1XP_036012499.1  RING finger protein unkempt homolog isoform X5

    Conserved Domains (2) summary
    PRK11448
    Location:306437
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:454487
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
  5. XM_036156605.1XP_036012498.1  RING finger protein unkempt homolog isoform X4

    UniProtKB/TrEMBL
    Q3V2Z5
    Conserved Domains (2) summary
    PRK11448
    Location:319450
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:467500
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
  6. XM_017314490.3XP_017169979.1  RING finger protein unkempt homolog isoform X2

    Conserved Domains (4) summary
    smart00356
    Location:4771
    ZnF_C3H1; zinc finger
    PRK11448
    Location:452583
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:600633
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:126150
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RNA

  1. XR_001779962.3 RNA Sequence

  2. XR_001779963.3 RNA Sequence

  3. XR_001779964.3 RNA Sequence

  4. XR_003949402.2 RNA Sequence