U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DCLK3 doublecortin like kinase 3 [ Homo sapiens (human) ]

Gene ID: 85443, updated on 25-Nov-2025
Official Symbol
DCLK3provided by HGNC
Official Full Name
doublecortin like kinase 3provided by HGNC
Primary source
HGNC:HGNC:19005
See related
Ensembl:ENSG00000163673 MIM:613167; AllianceGenome:HGNC:19005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLR; DCK3; DCDC3C; DCAMKL3
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein localization to nucleus. Predicted to act upstream of or within negative regulation of protein localization to nucleus and peptidyl-serine phosphorylation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in testis (RPKM 2.2), brain (RPKM 0.5) and 6 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See DCLK3 in Genome Data Viewer
Location:
3p22.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (36712421..36764553, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (36713774..36765897, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (36753912..36806044, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NBPF member 21, pseudogene Neighboring gene RN7SK pseudogene 227 Neighboring gene NANOG hESC enhancer GRCh37_chr3:36739560-36740214 Neighboring gene Sharpr-MPRA regulatory region 13437 Neighboring gene uncharacterized LOC105377029 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. Wierinckx A, et al. Endocr Relat Cancer, 2007 Sep. PMID 17914117
  2. Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling. Hill HE, et al. Protein Expr Purif, 2013 Mar. PMID 23247088, Free PMC Article
  3. Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor. Koth CM, et al. Biochemistry, 2010 Mar 9. PMID 20099900
  4. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. Ohmae S, et al. J Biol Chem, 2006 Jul 21. PMID 16684769
  5. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine/threonine-protein kinase DCLK3
Names
CLICK-I,II-related
doublecortin and CaM kinase-like 3
doublecortin domain-containing protein 3C
doublecortin-like and CAM kinase-like 3
NP_001381601.1
NP_208382.1
XP_047305046.1
XP_054204134.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394672.2 → NP_001381601.1  serine/threonine-protein kinase DCLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105749
    Consensus CDS
    CCDS93239.1
    UniProtKB/TrEMBL
    A0A1B0GTZ4
    Related
    ENSP00000489900.1, ENST00000636136.2
    Conserved Domains (2) summary
    cd14185
    Location:524 → 781
    STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)
    cd16111
    Location:93 → 177
    DCX_DCLK3; Doublecortin-like domain found in doublecortin-like kinase 3 (DCLK3)

  2. NM_033403.1 → NP_208382.1  serine/threonine-protein kinase DCLK3 isoform 2

    See identical proteins and their annotated locations for NP_208382.1

    Status: VALIDATED

    Source sequence(s)
    AB051552, AC105749, AK122988, DB075681, DR000236
    Consensus CDS
    CCDS43064.1
    UniProtKB/Swiss-Prot
    Q9C098
    UniProtKB/TrEMBL
    B3KVM3
    Related
    ENSP00000394484.2, ENST00000416516.2
    Conserved Domains (2) summary
    smart00220
    Location:356 → 613
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14185
    Location:355 → 612
    STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    36712421..36764553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449090.1 → XP_047305046.1  serine/threonine-protein kinase DCLK3 isoform X1

    Related
    ENSP00000599091.1, ENST00000929032.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    36713774..36765897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348159.1 → XP_054204134.1  serine/threonine-protein kinase DCLK3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C098.2 GenPept UniProtKB/Swiss-Prot:Q9C098

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools