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MRS4 Fe(2+) transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 853926, updated on 18-Sep-2024

Summary

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Official Symbol
MRS4
Official Full Name
Fe(2+) transporter
Primary source
SGD:S000001760
Locus tag
YKR052C
See related
AllianceGenome:SGD:S000001760; FungiDB:YKR052C; VEuPathDB:YKR052C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables iron ion transmembrane transporter activity. Involved in iron import into the mitochondrion. Located in mitochondrial inner membrane. Orthologous to human SLC25A28 (solute carrier family 25 member 28) and SLC25A37 (solute carrier family 25 member 37). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MRS4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (532550..533464, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Trk2p Neighboring gene Hfl1p Neighboring gene sphinganine kinase YSR3 Neighboring gene dynein heavy chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recovery of mrs3Δmrs4Δ Saccharomyces cerevisiae Cells under Iron-Sufficient Conditions and the Role of Fe(580). Moore MJ, et al. Biochemistry, 2018 Feb 6. PMID 29228768, Free PMC Article
  2. Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins. Brazzolotto X, et al. Biochem J, 2014 May 15. PMID 24624902
  3. The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane. Froschauer EM, et al. Biochim Biophys Acta, 2009 May. PMID 19285482
  4. A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. Mühlenhoff U, et al. J Biol Chem, 2003 Oct 17. PMID 12902335
  5. MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family. Wiesenberger G, et al. J Mol Biol, 1991 Jan 5. PMID 1703236

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three highly conserved histidine residues are important for Mrs3p function and mitochondrial iron transport when Mrs (mitochondrial RNA splicing)3p and Mrs4p are inserted into liposomes.
    Title: Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins.
  2. Inner mitochondrial membrane vesicles (SMPs) from the double deletion strain mrs3/4Delta failed to show a rapid Fe(2+) uptake, while SMPs from cells overproducing Mrs3/4p exhibited increased Fe(2+) uptake rates.
    Title: The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane.
  3. defective heme formation in mutants, with a markedly more severe defect in the DeltaDeltaDelta than in the individual Deltamrs3/4 or Deltayfh1 mutants
    Title: Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron import into the mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron import into the mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fe(2+) transporter
NP_012978.1
  • Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    532550..533464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179842.1 → NP_012978.1  TPA: Fe(2+) transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012978.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXB3, P23500
    UniProtKB/TrEMBL
    A7A012, B3LRC9, B5VMJ9, C7GNL3, C8ZCL6, G2WI80, N1P0Y0
    Conserved Domains (2) summary
    PTZ00168
    Location:27 → 252
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:205 → 304
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23500.1

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