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STRIP1 striatin interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 85369, updated on 23-Nov-2021

Summary

Official Symbol
STRIP1provided by HGNC
Official Full Name
striatin interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:25916
See related
Ensembl:ENSG00000143093 MIM:617918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM40A; FAR11A
Summary
This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 12.7), bone marrow (RPKM 10.4) and 25 other tissues See more
Orthologs
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Genomic context

See STRIP1 in Genome Data Viewer
Location:
1p13.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (110031577..110054641)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110574199..110597263)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 1 Neighboring gene adenosylhomocysteinase like 1 Neighboring gene uncharacterized LOC105378895 Neighboring gene ALX homeobox 3 Neighboring gene long intergenic non-protein coding RNA 1397

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14743, KIAA1761, MGC148091, RP4-773N10.1, 6330569M22Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
striatin-interacting protein 1
Names
FAR11 factor arrest 11 homolog A
family with sequence similarity 40, member A
homolog of yeast FAR11 protein 1
protein FAM40A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270768.2NP_001257697.1  striatin-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001257697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK027649, AL772411, BC040142
    Consensus CDS
    CCDS59197.1
    UniProtKB/Swiss-Prot
    Q5VSL9
    Related
    ENSP00000358811.1, ENST00000369796.5
    Conserved Domains (2) summary
    pfam07923
    Location:2231
    N1221; N1221-like protein
    pfam11882
    Location:365688
    DUF3402; Domain of unknown function (DUF3402)
  2. NM_033088.4NP_149079.2  striatin-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_149079.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB051548, BC040142, CB960147
    Consensus CDS
    CCDS30798.1
    UniProtKB/Swiss-Prot
    Q5VSL9
    Related
    ENSP00000358810.3, ENST00000369795.8
    Conserved Domains (2) summary
    pfam07923
    Location:66336
    N1221; N1221-like protein
    pfam11882
    Location:460783
    DUF3402; Domain of unknown function (DUF3402)

RNA

  1. NR_073071.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL834196, BC040142, DB460380
    Related
    ENST00000485775.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    110031577..110054641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002629.2XP_016858118.1  striatin-interacting protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07923
    Location:66328
    N1221; N1221-like protein
    pfam11882
    Location:460707
    DUF3402; Domain of unknown function (DUF3402)
  2. XM_006710995.2XP_006711058.1  striatin-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    pfam11882
    Location:154477
    DUF3402; Domain of unknown function (DUF3402)

RNA

  1. XR_002957854.1 RNA Sequence

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