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ZCCHC3 zinc finger CCHC-type containing 3 [ Homo sapiens (human) ]

Gene ID: 85364, updated on 25-Jan-2022

Summary

Official Symbol
ZCCHC3provided by HGNC
Official Full Name
zinc finger CCHC-type containing 3provided by HGNC
Primary source
HGNC:HGNC:16230
See related
Ensembl:ENSG00000247315 MIM:618326; AllianceGenome:HGNC:16230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf99
Summary
Enables double-stranded DNA binding activity. Involved in several processes, including cellular response to exogenous dsRNA; detection of virus; and positive regulation of RIG-I signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See ZCCHC3 in Genome Data Viewer
Location:
20p13
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (297570..300321)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (278211..280965)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene defensin beta 132 Neighboring gene chromosome 20 open reading frame 96 Neighboring gene NRSN2 antisense RNA 1 Neighboring gene SRY-box transcription factor 12

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with zinc finger, CCHC domain containing 3 (ZCCHC3) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104290

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of RIG-I signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger CCHC domain-containing protein 3
Names
zinc finger, CCHC domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033089.7NP_149080.2  zinc finger CCHC domain-containing protein 3

    See identical proteins and their annotated locations for NP_149080.2

    Status: VALIDATED

    Source sequence(s)
    BC036469, BC069238
    Consensus CDS
    CCDS42844.1
    UniProtKB/Swiss-Prot
    Q9NUD5
    Related
    ENSP00000484056.1, ENST00000500893.4
    Conserved Domains (1) summary
    cl26705
    Location:333386
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    297570..300321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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